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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Hepatoma Cell Growth Inhibition by Inducing Apoptosis with Polysaccharide Isolated from Turkey Tail Medicinal Mushroom, Trametes versicolor (L.: Fr.) Lloyd (Aphyllophoromycetideae)

Volume 12, Issue 3, 2010, pp. 257-263
DOI: 10.1615/IntJMedMushr.v12.i3.40
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ABSTRACT

The Trametes (=Coriolus) versicolor polysaccharide (CVP) is well known as an anti-tumor drug in clinical applications. Although recent studies have demonstrated that CVPs can inhibit the proliferation of cancer cells in vitro and in vivo, different purity levels of CVPs have a different affect on various cancer cells. In this study, crude CVPs were extracted and purified from T. versicolor dry fruit bodies by hot-water extraction, ethanol precipitation, and phenol-vitriolic colorimetry. The in vitro cytotoxic activities of CVPs were examined on the human hepatoma cancer (QGY) cell lines by using an MTT assay. The cell cycle and cell death (apoptosis) of QGY cells were investigated by flow cytometry. The expression of genes involved in the apoptosis process, such as p53, Bcl-2, and Fas, was also studied using reverse transcriptase-polymerase chain reaction (RT-PCR) techniques. These results showed that CVPs inhibited the proliferation of QGY in low concentrations (<20 mg/L) and the IC50 value was 4.25 mg/L. Changes that are characteristic of apoptosis, such as a found trapezoidal belt with DNA, were observed in the QGY cells treated with CVPs. There was a significant decrease in the expression of the cell cycle-related genes (p53, Bcl-2, and Fas,) in these cells following treatment with CVPs. These results thus indicate that CVPs can be a potential candidate to ameliorate toxic effects when used in cancer therapy.

CITED BY
  1. Patel Seema, Goyal Arun, Recent developments in mushrooms as anti-cancer therapeutics: a review, 3 Biotech, 2, 1, 2012. Crossref

  2. Zhang Jiao-Jiao, Li Ya, Zhou Tong, Xu Dong-Ping, Zhang Pei, Li Sha, Li Hua-Bin, Bioactivities and Health Benefits of Mushrooms Mainly from China, Molecules, 21, 7, 2016. Crossref

  3. Mohamed Shimaa Ibrahim Abdelmonym, Jantan Ibrahim, Haque Md. Areeful, Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action, International Immunopharmacology, 50, 2017. Crossref

  4. Osińska-Jaroszuk Monika, Sulej Justyna, Jaszek Magdalena, Jaroszuk-Ściseł Jolanta, Applications of Fungal Polysaccharides, in Encyclopedia of Mycology, 2021. Crossref

  5. Vijayalakshmi S., Karthik K., Winny Fred Crossia A., Subashini G., Bhuvaneswari S., Panneerselvam A., Thatikayala Dayakar, Park Jinsub, Park Mi-Kyung, Fungal secondary metabolites: A potential source of anticancer compounds, in New and Future Developments in Microbial Biotechnology and Bioengineering, 2020. Crossref

  6. Pathak Manash Pratim, Pathak Kalyani, Saikia Riya, Gogoi Urvashee, Ahmad Mohammad Zaki, Patowary Pompy, Das Aparoop, Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review, Biomedicine & Pharmacotherapy, 149, 2022. Crossref

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