Published 12 issues per year
ISSN Print: 1521-9437
ISSN Online: 1940-4344
IF:
1.4
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.318
SNIP:
0.415
CiteScore™:
2.6
H-Index:
41
Indexed in
Immunomodulation of Bone Marrow Macrophages by GLIS, a Proteoglycan Fraction from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidium (W.Curt.:Fr.) P. Karst.
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ABSTRACT
The immunomodulatory effect of GLIS (Lingzhi or Reishi medicinal mushroom Ganoderma lucidum immunomodulating substance) on macrophages has been investigated as part of ongoing research into the anticancer properties of this mushroom. Proliferation of bone marrow macrophages (BMMs) was enhanced by GLIS in a dose-dependent manner. Microscopic examination revealed that numerous GLIS-treated BMMs were enlarged and formed pseudopodia. Exposure of BMMs to GLIS resulted in significant increases in NO production, induction of cellular respiratory burst activity, and increased levels of IL-1β, IL-6, IL-12p35, IL-12p40, IL-18, and TNF-α gene expression and levels of TNF-α, IL-1β, and IL-12 secretion. Our data indicate that GLIS activates the immune system by modulating cytokine production.
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Zhou Yan, Chen Song, Ding Ran, Yao Wenbing, Gao Xiangdong, Inflammatory Modulation Effect of Glycopeptide fromGanoderma capense(Lloyd) Teng, Mediators of Inflammation, 2014, 2014. Crossref
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Wang Xin, Lin Zhibin, Immunomodulating Effect of Ganoderma (Lingzhi) and Possible Mechanism, in Ganoderma and Health, 1182, 2019. Crossref
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Viviana Loria-Kohen , Thais Lourenço-Nogueira , Isabel Espinosa-Salinas , Francisco R. Marín , Cristina Soler-Rivas , Ana Ramirez de Molina , Nutritional and Functional Properties of Edible Mushrooms: A Food with Promising Health Claims, Journal of Pharmacy and Nutrition Sciences , 4, 3, 2014. Crossref