Published 12 issues per year
ISSN Print: 1521-9437
ISSN Online: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Effect of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Capsules on Colistin-Induced Nephrotoxicity
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ABSTRACT
The aim of this experimental study was to investigate the protective effect of Ganoderma lucidum capsules against colistin nephrotoxicity. The study animals were separated into four groups: control, colistin (9 mg/kg), colistin−G. lucidum 50 mg/kg, and colistin−G. lucidum 100 mg/kg. In the colistin group, serum blood urea nitrogen and creatinine values were found to be higher than those of the other groups (p < 0.001). The malondialdehyde, catalase, total oxidative stress, oxidative stress index, and oxidized glutathione values in serum and kidney tissue samples were determined to be higher in the colistin group than in the other groups (p < 0.001). The total antioxidative stress, superoxide dismutase, glutathione peroxidase, and glutathione values measured in the serum and kidney tissue samples were determined to be lower in the colistin group (p < 0.001). Oxidative stress is responsible for tubule damage in colistin nephrotoxicity, and when G. lucidum is used together with colistin, renal damage is reduced.
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Arslan BY, Arslan F, Erkalp K, Alagol A, Sevdi MS, Yildiz G, Kucuk SH, Altinay S. Luteolin ameliorates colistin-induced nephrotoxicity in the rat models. Ren Fail. 2016;38(10):1735-40.
-
Dai C, Tang S, Wang Y, Velkov T, Xiao X. Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response. J Antimicrob Chemother. 2017;72(9):2562-69.
-
Talih G, Esmaoglu A, Bayram A, Yazici C, Deniz K, Talih, T. Does dexmedetomidine prevent colistin nephrotoxicity? Rev Bras Anestesiol. 2018;68(4):383-87.
-
Lee JM, Kwon H, Jeong H, Lee JW, Lee SY, Baek SJ, Surh YJ. Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res. 2001;15(3):245-49.
-
Pillai TG, John M, Thomas GS. Prevention of cisplatin induced nephrotoxicity by terpenes isolated from Ganoderma lucidum occurring in southern parts of India. Exp Toxicol Pathol. 2011;63(1-2):157-60.
-
Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH, Yu PHF, Leung GPH, Ngai SM, Yeung JHK, Leung PS, Lee SMY, Kwan YW. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+ db/+ db) mice. Phytomedicine. 2009;16(5):426-36.
-
Ozkan G, Ulusoy S, Orem A, Alkanat M, Mungan S, Yulug E, Yucesan B. How does colistin-induced nephropathy develop and can it be treated? Antimicrob Agents Chemother. 2013;57(8);3463-69.
-
Smina TP, Mathew J, Janardhanan KK, Devasagayam TPA. Antioxidant activity and toxicity profile of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst. occurring in south India. Environ Toxicol Pharmacol. 2011;32(3):438-46.
-
Gao Y, Zhou S, Chen G, Dai X, Ye J. A phase I/II study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. extract (ganopoly) in patients with advanced cancer. Int J Med Mushrooms. 2002;4(3). doi:10.1615/IntJMedMushr.v4.i3.30.
-
Yousef JM, Chen G, Hill PA, Nation RL, Li J. Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics. J Antimicrob Chemother. 2011;67(2):452-59.
-
Yousef JM, Chen G, Hill PA, Nation RL, Li J. Melatonin attenuates colistin-induced nephrotoxicity in rats. J Antimicrob Chemother. 2011;55(9):4044-49.
-
Edrees NE, Galal AA, Monaem ARA, Beheiry RR, Metwally MM. Curcumin alleviates colistin-induced nephrotoxicity and neurotoxicity in rats via attenuation of oxidative stress, inflammation and apoptosis. Chem Biol Interact. 2018;294:56-64.
-
Li T, Yu H, Song Y, Zhang R, Ge M. Protective effects of Ganoderma triterpenoids on cadmium-induced oxidative stress and inflammatory injury in chicken livers. J Trace Elem Med Biol. 2019;52:118-25.
-
Lou HW, Guo XY, Zhang XC, Guo LQ, Lin JF. Optimization of cultivation conditions of lingzhi or reishi medicinal mushroom, Ganoderma lucidum (Agaricomycetes) for the highest antioxidant activity and antioxidant content. Int J Med Mushrooms. 2019;21(4):353-66.
-
Zhang Y, Lin Z, Hu Y, Wang F. Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on "living high-training low." Br J Sports Med. 2008;42(10):819-22.
-
Sliva D. Ganoderma lucidum (Reishi) in cancer treatment. Integr Cancer Ther. 2003;2(4):358-64.
-
Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: A pilot clinical trial. Evid Based Complement Alternat Med. 2012;2012:809614.
-
Zhong D, Wang H, Liu M, Li X, Huang M, Zhou H, Lin S, Lin Z, Yang B. Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress. Sci Rep. 2015;5:16910.
-
Jin H, Jin F, Jin JX, Xu J, Tao TT, Liu J, Huang HJ. Protective effects of Ganoderma lucidum spore on cadmium hepatotoxicity in mice. Food Chem Toxicol. 2013;52:171-75.
-
Jiao C, Chen W, Tan X, Liang H, Li J, Yun H, He C, Chen J, Ma X, Xie Y, Yang BB. Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9. J Ethnopharmacol. 2020;247:112256.
-
Gai Z, Samodelov SL, Kullak-Ublick GA, Visentin M. Molecular mechanisms of colistin-induced nephrotoxicity. Molecules. 2019;24(3):E653.