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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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High Immunomodulatory and Preventive Effects Against Sarcoma 180 in Mice Fed with Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Mycelium

Volume 10, Issue 1, 2008, pp. 37-48
DOI: 10.1615/IntJMedMushr.v10.i1.50
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ABSTRACT

This study evaluated the immunomodulatory and antitumor effects of a diet supplemented with Ganoderma lucidum (Ling Zhi or Reishi) medicinal mushroom mycelium obtained by solid-state fermentation. Over 14 weeks, animals from a test group were fed with 2 concentrations of G. lucidum mycelium, at 85% or 50%, labeled G85 and G50 diets, respectively. A control group received a regular diet. In the tenth week, half the animals from the test group and half the animals from the control group were inoculated with a suspension of Sarcoma 180 cells. Saline was injected in the remaining animals. In week 14, plasma levels of cytokines and the population of CD3+, CD4+, CD8+, CD19+, and CD16+/ CD32+ cells were evaluated. When compared to the control group, G. lucidum-supplemented diets altered the immune systems of the mice significantly (p < 0.05) the G50 diet proving more effective than the G85 diet. Mice inoculated with saline and fed with the G50 diet presented an increase in CD19+ and CD16+/CD32+ cell populations, along with an elevation in the tumor necrosis factor (TNF)-α and interferon (IFN)-γ concentrations. Conversely, tumor-bearing mice fed with the G50 diet (labeled the G50-S group) presented an increase in CD3+, CD4+, and CD8+ cells, but a decrease in CD19+ and CD16+/ CD32+ cell populations. TNF-α and IFN-γ concentrations were reduced in the G50-S group. The G50-S group presented a tumor weight 84% lower than that found in the control group. These results suggest that the immunomodulatory effect provoked by the consumption of G. lucidum mycelium possibly increased mice resistance against Sarcoma 180.

CITED BY
  1. Rubel Rosália, Dalla Santa Herta S., Fernandes Luiz Cláudio, Bonatto Sandro J. R., Bello Sérgio, Figueiredo Bonald C., Lima Filho José Hermenio C., Santos Cid Aimbiré M., Soccol Carlos Ricardo, Hypolipidemic and antioxidant properties of Ganoderma lucidum (Leyss:Fr) Karst used as a dietary supplement, World Journal of Microbiology and Biotechnology, 27, 5, 2011. Crossref

  2. Rubel Rosália, Dalla Santa Herta S., Bonatto Sandro J.R., Bello Sérgio, Fernandes Luiz Cláudio, Di Bernardi Raffaello, Gern Juliana, Santos Cid Aimbiré M., Soccol Carlos Ricardo, Medicinal Mushroom Ganoderma lucidum (Leyss: Fr) Karst. Triggers Immunomodulatory Effects and Reduces Nitric Oxide Synthesis in Mice, Journal of Medicinal Food, 13, 1, 2010. Crossref

  3. Dalla-Sant H.S., Rubel R., Vitola F.M.D., Rodriguez- J.A., Dalla-Sant O.R., Brand D., Alvarez D.C., Macedo R.E.F., Carvalho J.C., Soccol C.R., Growth Parameters of Agaricus brasiliensis Mycelium on Wheat Grains in Solid-state Fermentation, Biotechnology(Faisalabad), 11, 3, 2012. Crossref

  4. Dalla-Santa Herta S., Rubel Rosália, Vitola Francisco M.D., Buchi Dorli, Di-Bernardi Raffaello P., Moreno Andréa N., Lima-Filho José H.C., Dalla-Santa Osmar R., Gern Juliana C., Monteiro Marta C., Fernandes Luis C., Soccol Carlos R., Agaricus brasiliensismycelium supplementation in Sarcoma 180tumour-bearing mice reverses the immune response induced by the tumour, Food and Agricultural Immunology, 24, 2, 2013. Crossref

  5. Sui Xiao-chen, Guo Qing-bin, Xia Yong-mei, Cui Steve W., Shen Jie, Zhang Jue, Ding Zhong-yang, Structure features of the intracellular polysaccharide from Ganoderma lucidum and the irrelative immune-anticancer activities of GLPs, Bioactive Carbohydrates and Dietary Fibre, 8, 2, 2016. Crossref

  6. Zhang Jiao-Jiao, Li Ya, Zhou Tong, Xu Dong-Ping, Zhang Pei, Li Sha, Li Hua-Bin, Bioactivities and Health Benefits of Mushrooms Mainly from China, Molecules, 21, 7, 2016. Crossref

  7. Santos Glauco Jonas Lemos, Oliveira Emanuele Silva, Pinheiro Ana Débora Nunes, da Costa Patricia Marçal, de Freitas José Claudio Carneiro, de Araújo Santos Francisco Glauco, Maia Fernanda Maria Machado, de Morais Selene Maia, Nunes-Pinheiro Diana Célia Sousa, Himatanthus drasticus (Apocynaceae) latex reduces oxidative stress and modulates CD4+, CD8+, FoxP3+ and HSP-60+ expressions in Sarcoma 180-bearing mice, Journal of Ethnopharmacology, 220, 2018. Crossref

  8. Santa Herta Stutz Dalla, Romão Pedro Roosevelt Torres, Sovrani Vanessa, Oliveira Fabio Rodrigues, Peres Alessandra, Monteiro Marta Chagas, Dietary Polysaccharides and Immune Modulation, in Polysaccharides, 2015. Crossref

  9. Thakur Monika, Wild Macro-Fungi from Northwest Himalayas: Future Prospects and Challenges, in Biology of Macrofungi, 2018. Crossref

  10. Santa Herta Stutz Dalla, Romão Pedro Roosevelt Torres, Sovrani Vanessa, Oliveira Fabio Rodrigues, Peres Alessandra, Monteiro Marta Chagas, Dietary Polysaccharides and Immune Modulation, in Polysaccharides, 2014. Crossref

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