Library Subscription: Guest
International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Efficient Accumulation and In Vitro Antitumor Activities of Triterpene Acids from Submerged Batch−Cultured Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes)

Volume 19, Issue 5, 2017, pp. 419-431
DOI: 10.1615/IntJMedMushrooms.v19.i5.40
Get accessGet access

ABSTRACT

Triterpene acids are among the major bioactive constituents of lucidum. However, submerged fermentation techniques for isolating triterpene acids from G. lucidum have not been optimized for commercial use, and the antitumor activity of the mycelial triterpene acids needs to be further proven. The aim of this work was to optimize the conditions for G. lucidum culture with respect to triterpene acid production, scaling up the process, and examining the in vitro antitumor activity of mycelial triterpene acids. The key conditions (i.e., initial pH, fermentation temperature, and rotation speed) were optimized using response surface methodology, and the in vitro antitumor activity was evaluated using the MTT method. The optimum key fermentation conditions for triterpene acid production were pH 6.0; rotation speed, 161.9 rpm; and temperature, 30.1°C, resulting in a triterpene acid yield of 291.0 mg/L in the validation experiment in a 5-L stirred bioreactor; this yield represented a 70.8% increase in titer compared with the nonoptimized conditions. Furthermore, the optimized conditions were then successfully scaled up to a production scale of 200 L, and a triterpene productivity of 47.9 mg/L/day was achieved, which is, to our knowledge, the highest reported in the large-scale fermentation of G. lucidum. In addition, the mycelial triterpene acids were found to be cytotoxic to the SMMC-7721 and SW620 cell lines in vitro. Chemical analysis showed that the key active triterpene acid compounds, ganoderic acids T and Me, predominated in the extract, at 69.2 and 41.6 mg/g, respectively. Thus, this work develops a simple and feasible batch fermentation technique for the large-scale production of antitumor triterpene acids from G. lucidum.

CITED BY
  1. Badalyan Susanna M., Barkhudaryan Anush, Rapior Sylvie, Recent Progress in Research on the Pharmacological Potential of Mushrooms and Prospects for Their Clinical Application, in Medicinal Mushrooms, 2019. Crossref

  2. Hyder Md Salman, Dutta Sayan Deb, Mushroom-derived polysaccharides as antitumor and anticancer agent: A concise review, Biocatalysis and Agricultural Biotechnology, 35, 2021. Crossref

  3. Wu Qiang, Li Yong, Peng Kuan, Wang Xiao-Ling, Ding Zhongyang, Liu Liming, Xu Peng, Liu Gao-Qiang, Isolation and Characterization of Three Antihypertension Peptides from the Mycelia of Ganoderma Lucidum (Agaricomycetes), Journal of Agricultural and Food Chemistry, 67, 29, 2019. Crossref

1214 Article views 56 Article downloads Metrics
1214 VIEWS 56 DOWNLOADS 3 Crossref CITATIONS Google
Scholar
CITATIONS

Articles with similar content:

Mycelial Biomass and Biochemical Properties of Proteases Produced by Lentinus citrinus DPUA 1535 (Higher Basidiomycetes) in Submerged Cultivation International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 5
Maria Francisca Simas Teixeira, Larissa de Souza Kirsch, Valeria de Carvalho Santos Ebinuma
Nutritional Requirements for Mycelial Growth of Milk-White Toothed Mushroom, Irpex lacteus (Agaricomycetes), in Submerged Culture International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 9
Xiaoming Dong, Xinhua Song, Caihong Dong
Cordycipitoid Fungi Powders Promote Mycelial Growth and Bioactive-Metabolite Production in Liquid Cultures of the Stout Camphor Medicinal Mushroom Taiwanofungus camphoratus (Agaricomycetes) International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 7
Hong Yu, Qi Fan, Yao Wang, Yuan-Bing Wang, Yan-Fang Liu
Simple and Reproducible Two-Stage Agitation Speed Control Strategy for Enhanced Triterpene Production by Lingzhi or Reishi Medicinal Mushrooms, Ganoderma lucidum ACCC G0119 (Higher Basidiomycetes) Based on Submerged Liquid Fermentation International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 12
Yan Yang, Fang Liu, Jingsong Zhang, Chi-Chung Lin, Wei Jia, Jie Feng, Na Feng
Employment of ARTP to Generate Phellinus baumii (Agaricomycetes) Strain with High Flavonoids Production and Validation by Liquid Fermentation International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 12
Di Wu, Dehui Qu, Yan Yang, Fuchun Jiang, Henan Zhang, Jingsong Zhang, Wenhan Wang, Yating Dong
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain