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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Characterization and Antiproliferative Effect of Novel Acid Polysaccharides from the Spent Substrate of Shiitake Culinary-Medicinal Mushroom Lentinus edodes (Agaricomycetes) Cultivation

Volume 19, Issue 5, 2017, pp. 395-403
DOI: 10.1615/IntJMedMushrooms.v19.i5.20
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ABSTRACT

In this study, a high yield of crude polysaccharide (16.73 ± 0.756%) was extracted from the spent mushroom substrate of Lentinus edodes using a hot alkali extraction method. Two groups of polysaccharides (designated as LSMS-1 and LSMS-2) were obtained from the crude extract by size exclusion chromatography (SEC), and their molecular characteristics were examined by a multiangle laser-light scattering (MALLS) and refractive index detector system. The weight-average molar masses of LSMS-1 and LSMS-2 were determined to be 6.842 × 106 and 2.154 × 106 g/mol, respectively. The SEC/MALLS analysis revealed that the molecular shapes of LSMS-1 and LSMS-2 were sphere-like forms in aqueous solution. Carbohydrate composition analysis using chromatography−mass spectrometry revealed that they were both acid heteropolysaccharides. LSMS-1 comprised mainly glucose and galacturonic acid, whereas LSMS-2 mainly consisted of xylose and glucuronic acid. Fourier transform infrared spectral analysis of the purified fractions revealed typical characteristic polysaccharide groups. In addition, MTT assays with refined polysaccharide doses of 25, 50, 100, 200, and 400 µg/mL suggested that both of the polysaccharide fractions exhibited antiproliferative activity against 6 tested human tumor cell lines in a concentration-dependent manner, and LSMS-2 had better anticancer capacity in vitro than LSMS-1. The inhibition ratio of LSMS-2 against A549 human lung cancer cells, the SGC7901 gastric cancer cell line, MCF-7 breast cancer cells, the U937 histiocytic lymphoma cell line, and the MG-63 human osteosarcoma cell line reached 43.55%, 29.97%, 19.63%, 18.24%, and 17.93%, respectively, at a concentration of 400 µg/mL.

CITED BY
  1. Phan Chia-Wei, Tan Elson Yi-Yong, Sabaratnam Vikineswary, Bioactive Molecules in Edible and Medicinal Mushrooms for Human Wellness, in Sweeteners, 2018. Crossref

  2. Cao Shi-Yu, Li Ya, Meng Xiao, Zhao Cai-Ning, Li Sha, Gan Ren-You, Li Hua-Bin, Dietary natural products and lung cancer: Effects and mechanisms of action, Journal of Functional Foods, 52, 2019. Crossref

  3. Phan Chia-Wei, Tan Elson Yi-Yong, Sabaratnam Vikineswary, Bioactive Molecules in Edible and Medicinal Mushrooms for Human Wellness, in Bioactive Molecules in Food, 2019. Crossref

  4. Badalyan Susanna M., Barkhudaryan Anush, Rapior Sylvie, Recent Progress in Research on the Pharmacological Potential of Mushrooms and Prospects for Their Clinical Application, in Medicinal Mushrooms, 2019. Crossref

  5. Bhuyan Nilutpal, Narzari Rumi, Gogoi Lina, Bordoloi Neonjyoti, Hiloidhari Moonmoon, Palsaniya D.R., Deb Utsab, Gogoi Nirmali, Kataki Rupam, Valorization of agricultural wastes for multidimensional use, in Current Developments in Biotechnology and Bioengineering, 2020. Crossref

  6. Sheng Kangjia, Wang Cuiling, Chen Bitao, Kang Meijuan, Wang Minchang, Liu Ke, Wang Ming, Recent advances in polysaccharides from Lentinus edodes (Berk.): Isolation, structures and bioactivities, Food Chemistry, 358, 2021. Crossref

  7. Elhusseiny Shaza M., El-Mahdy Taghrid S., Awad Mohamed F., Elleboudy Nooran S., Farag Mohamed M. S., Yassein Mahmoud A., Aboshanab Khaled M., Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible Mushrooms, Molecules, 26, 15, 2021. Crossref

  8. Atila F., Cultivation and Utilization of Shiitake Mushroom, in Medicinal Plants, 28, 2021. Crossref

  9. Maity Prasenjit, Sen Ipsita K., Chakraborty Indranil, Mondal Soumitra, Bar Harekrishna, Bhanja Sunil K., Mandal Soumitra, Maity Gajendra Nath, Biologically active polysaccharide from edible mushrooms: A review, International Journal of Biological Macromolecules, 172, 2021. Crossref

  10. Guo Qi, Liang Shuangmin, Xiao Zhichao, Ge Changrong, Research progress on extraction technology and biological activity of polysaccharides from Edible Fungi: A review, Food Reviews International, 2022. Crossref

  11. Diana Martinho , Amin Karmali , Effect of Intracellular and Extracellular Mushroom Polysaccharides on Growth Inhibition of Human Carcinoma Cell Lines , Journal of Cancer Research Updates, 8, 1, 2019. Crossref

  12. Chen Liping, He Chunrong, Zhou Min, Long Jiaying, Li Ling, Research Progress on the Mechanisms of Polysaccharides against Gastric Cancer, Molecules, 27, 18, 2022. Crossref

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