年間 4 号発行
ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537
Indexed in
Protective Role of Perillic Acid Against Radiation−Induced Oxidative Stress, Cytokine Profile, DNA Damage, and Intestinal Toxicity in Mice
要約
The radioprotective effect of perillic acid was studied using an in vivo mouse model. Whole-body exposure of Swiss albino mice to γ-rays (6 Gy) reduced the total white blood cell count to 1035 ± 378 cells/mm3 on the 9th day, which was significantly elevated to 2196 ± 382 cells/mm3 by the administration of perillic acid (50 μmoles/kg body weight, intraperitoneally) on the same day. The number of bone marrow cells and α-esterase positive cells in control animals after 11 days of irradiation was reduced to 12.5 ± 0.8 × 106 cells/femur and 674 ± 45.2/4000 cells, respectively. In perillic acid treated animals, bone marrow cellularity was increased to 14.8 ± 1.8 × 106 cells/femur and α-esterase positive cells were 941 ± 56.5 /4000 cells, similar to normal level (935 ± 51.4/4000 cells). Administration of perillic acid could reduce the radiation-induced elevated levels of alkaline phosphatase (ALP), glutathione-pyruvate transferase (GPT) and lipid peroxidation (LPO) in both serum and liver of irradiated animals. Perillic acid could significantly enhance the glutathione (GSH) content in liver and intestinal mucosa of irradiated animals. Histopathological analysis of small intestine also suggests that perillic acid could reduce the radiation-induced intestinal damage. The level of proinflammatory cytokines such as IL-1β, TNF-α and CRP, which were elevated during irradiation, was significantly reduced by the Perillic acid administration. Perillic acid treatment could also stimulate the production of other cytokines such as GM-CSF and IFN-γ in animals exposed to whole-body gamma irradiation. Agarose gel electrophoresis of DNA isolated from bone marrow of mice exposed to gamma radiation showed heavy damage that was reduced by treatment with perillic acid.
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Rithidech Kanokporn Noy, Tungjai Montree, Reungpatthanaphong Paiboon, Honikel Louise, Simon Sanford R., Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 749, 1-2, 2012. Crossref
-
Kuffler Damien P., Hyperbaric oxygen therapy: Can it prevent irradiation-induced necrosis?, Experimental Neurology, 235, 2, 2012. Crossref
-
Turkez Hasan, Aydın Elanur, Geyikoglu Fatime, Cetin Damla, Genotoxic and oxidative damage potentials in human lymphocytes after exposure to terpinolene in vitro, Cytotechnology, 67, 3, 2015. Crossref
-
Zaher Nashwa H., Salem Asmaa A.M., Ismail Amel F.M., Novel amino acid derivatives bearing thieno[2,3-d]pyrimidine moiety down regulate NF-κB in γ-irradiation mediated rat liver injury, Journal of Photochemistry and Photobiology B: Biology, 165, 2016. Crossref
-
El-Gazzar Marwa G., Zaher Nashwa H., El-Hossary Ebaa M., Ismail Amel F.M., Radio-protective effect of some new curcumin analogues, Journal of Photochemistry and Photobiology B: Biology, 162, 2016. Crossref
-
Wang Huailing, Liu Jie, Pang Daorui, Li Tong, Liu Rui Hai, Mechanisms underlying the protective effects of blueberry extract against ultraviolet radiation in a skin cell co-culture system, Journal of Functional Foods, 52, 2019. Crossref
-
Li Yuanyuan, Kong Shaofan, Yang Fujun, Xu Wenqing, Protective Effects of 2-Amino-5,6-dihydro-4H-1,3-thiazine and Its Derivative against Radiation-Induced Hematopoietic and Intestinal Injury in Mice, International Journal of Molecular Sciences, 19, 5, 2018. Crossref
-
Prasad Shilpi K., Bose Ananya, Bhattacharjee Ankita, Banerjee Oly, Singh Siddhartha, Mukherjee Sandip, Pal Swagata, Radioprotective effect of ethanolic extract of Alocasia indica on γ-irradiation-induced reproductive alterations in ovary and uterus, International Journal of Radiation Biology, 95, 11, 2019. Crossref
-
Nepal Mahesh Raj, Kang Mi Jeong, Kim Geon Ho, Cha Dong Ho, Nam Doo Hyun, Jeong Tae Cheon, Identification of pre- and pro-haptens with a β-galactosidase-expressing E. coli culture system for skin sensitization, Toxicology Letters, 305, 2019. Crossref
-
Fernandes Janaina, Antitumor Monoterpenes, in Bioactive Essential Oils and Cancer, 2015. Crossref
-
Radwan Rasha R., Hasan Hesham F., Pioglitazone ameliorates hepatic damage in irradiated rats via regulating anti-inflammatory and antifibrogenic signalling pathways, Free Radical Research, 53, 7, 2019. Crossref
-
Proshkina Ekaterina, Plyusnin Sergey, Babak Tatyana, Lashmanova Ekaterina, Maganova Faniya, Koval Liubov, Platonova Elena, Shaposhnikov Mikhail, Moskalev Alexey, Terpenoids as Potential Geroprotectors, Antioxidants, 9, 6, 2020. Crossref
-
Xiong Ling, Wang Long, Zhang Ting, Ye Xinyuan, Huang Feihong, Huang Qianqian, Huang Xinwu, Wu Jianming, Zeng Jing, UHPLC/MS-Based Serum Metabolomics Reveals the Mechanism of Radiation-Induced Thrombocytopenia in Mice, International Journal of Molecular Sciences, 23, 14, 2022. Crossref