ライブラリ登録: Guest
Journal of Environmental Pathology, Toxicology and Oncology

年間 4 号発行

ISSN 印刷: 0731-8898

ISSN オンライン: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Evaluating the Anti-Fertility Potential of α-Chlorohydrin on Testis and Spermatozoa in the Adult Male Wild Indian House Rat (Rattus rattus)

巻 30, 発行 2, 2011, pp. 93-102
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i2.10
Get accessGet access

要約

To examine the effects of α-chlorohydrin on testis and cauda epididymis in the male house rat (Rattus rattus), 24 adult male rats were segregated into two groups. Group I rats were force-fed daily by intragastric intubation with α-chlorohydrin at a single dose of 1.0 mg/100 g body weight/d for 5, 15, and 45 days. Another group was fed with distilled water, which served as the control. The treated male rats were paired with 24 adult proestrus female rats for 5 days after the last oral treatment and fertility was tested. At the end of the experiments, all of the male rats were weighed and killed by cervical dislocation. The right testes were removed, weighed, and processed for ultrastructural changes of spermatozoa from the cauda epididymis and testis under scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The seminiferous tubular area, nuclear diameter of the Sertoli and Leydig cells, percentage of spermatogonia, primary spermatocytes, secondary spermatocytes, spermatids, spermatozoa, and Sertoli cells in each group were compared morphometrically. Our results showed that the percentages of primary spermatocytes steadily increased from 5 to 15 days, but primary and secondary spermatocytes decreased significantly at 45 days. There was a steady decline in the percentages of spermatozoa and spermatids at all fixation intervals in the treated animals, but the percentages of spermatogonia and Sertoli cells increased significantly at 15 and 45 days. Seminiferous tubular areas, nuclear diameter of Leydig and Sertoli cells, and fertility rates were reduced after 45 days of treatment. SEM and TEM studies revealed severe morphological abnormalities in the spermatozoa, including deglutination of the acrosomal part, loss of head capsules, and fragmentation of tail fibrils. There was an enhanced anti-fertility effect and a lower number of implantation sites in the rats treated for 5 days. Our results validate α-chlorohydrin as a successful anti-fertility agent that prevents spermatogenesis.

によって引用された
  1. Mahapatra Dakshayani, Chandra Amar K, Biphasic action of iodine in excess at different doses on ovary in adult rats, Journal of Trace Elements in Medicine and Biology, 39, 2017. Crossref

  2. Mahmoud YI, Taha A, Soliman S, 3-Monochloropropane-1,2-diol (alpha-chlorohydrin) disrupts spermatogenesis and causes spermatotoxicity in males of the Egyptian fruit-bat (Rousettus aegyptiacus), Biotechnic & Histochemistry, 93, 4, 2018. Crossref

  3. Madhu Nithar Ranjan, Sarkar Bhanumati, Slama Petr, Jha Niraj Kumar, Ghorai Sudipta Kumar, Jana Sandip Kumar, Govindasamy Kadirvel, Massanyi Peter, Lukac Norbert, Kumar Dhruv, Kalita Jogen C., Kesari Kavindra Kumar, Roychoudhury Shubhadeep, Effect of Environmental Stressors, Xenobiotics, and Oxidative Stress on Male Reproductive and Sexual Health, in Oxidative Stress and Toxicity in Reproductive Biology and Medicine, 1391, 2022. Crossref

701 記事の閲覧数 43 記事のダウンロード 記事の統計
701 記事の閲覧数 43 記事のダウンロード 3 Crossref 引用数 Google
Scholar
引用数

類似内容の記事:

Effects of Aegle marmelos (L.) Correa on the Peripheral Blood and Small Intestine of Mice Exposed to Gamma Radiation Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 4
Ponemone Venkatesh, Parampally Archana, Ganesh Chandra Jagetia, Manjeshwar Shrinath Baliga, Bhandarkar R. Krishnanand
Reversal of Lead-Induced Acute Toxicity by Lipoic Acid with Nutritional Supplements in Male Wistar Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 2
Sadhana Shrivastava, Yamini Sharma, Sangeeta Shukla
Response of Silkworm Larvae to Atmospheric Pressure Nonthermal Plasma Irradiation Plasma Medicine, Vol.6, 2016, issue 3-4
Thapanut Sarinont, Yosuke Wada, Masaharu Shiratani, Kazunori Koga
Protective Effect of D-Carvone against Dextran Sulfate Sodium Induced Ulcerative Colitis in Balb/c Mice and LPS Induced RAW Cells via the Inhibition of COX-2 and TNF-α Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 3
Shuang Wu, Guo Wang, Xiaoyan Zhu, Chengzhen Li
Anxiolytic Effects of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) on Ischemia-Induced Anxiety in Rats International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 1
Ying Liu, Yan Sun, Xiulan Gao, Haitao Yu, Yanmin Wu, Guangcheng Cui, Chun-Jing Zhang, Xiaojie Sun
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集 価格及び購読のポリシー Begell House 連絡先 Language English 中文 Русский Português German French Spain