年間 4 号発行
ISSN 印刷: 0731-8898
ISSN オンライン: 2162-6537
Indexed in
Protective Effect of Diltiazem (a Calcium Channel Blocker) against Cadmium-Induced Toxicity in Mice
要約
Protective efficacy of diltiazem (a calcium channel blocker) has been studied against cadmium chloride (CdCl2) induced hematological and biochemical alterations in Swiss albino mice. CdCl2 (5 mg/kg b.wt.; i.p.) with or without prior treatment of diltiazem (100 mg/kg b. wt.; i.p.) was given to six-week old mice. Significant increase in the number of bone marrow cells as well as hematological parameters was observed in diltiazem pretreated CdCl2 intoxicated animals. A significant increase in lipid peroxidation (LPO) and acid phosphatase (ACP) level, and decrease in glutathione (GSH) and alkaline phosphatase (ALP) level in blood as well as liver were measured in CdCl2 intoxicated mice, while such values were near normal in DTZ pretreated animals. Furthermore, a significant increase in erythropoeitin (EPO) level was observed in diltiazem (DTZ) pretreated CdCl2 intoxicated animals as compared to CdCl2 alone treated animals. Thus, Diltiazem administration before cadmium intoxication protects bone marrow and hematological constituents in mice.
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Karabulut-Bulan Omur, Bolkent Sehnaz, Yanardag Refiye, Bilgin-Sokmen Bahar, The Role of Vitamin C, Vitamin E, and Selenium on Cadmium-Induced Renal Toxicity of Rats, Drug and Chemical Toxicology, 31, 4, 2008. Crossref
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Sun Ying, Liou Benjamin, Quinn Brian, Ran Huimin, Xu You-Hai, Grabowski Gregory A., Schiffmann Raphael, In Vivo and Ex Vivo Evaluation of L-Type Calcium Channel Blockers on Acid β-Glucosidase in Gaucher Disease Mouse Models, PLoS ONE, 4, 10, 2009. Crossref