年間 4 号発行
ISSN 印刷: 2694-4642
ISSN オンライン: 2694-4650
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Activation of Mast Cells by Acupuncture Stimuli
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要約
In traditional Chinese medicine, selected points on the body surface, the acupuncture points, are treated by various physical stimuli. Degranulation of subcutaneous mast cells has been suggested to be involved in initiation of the acupuncture effects. Here we give an overview on our recent research illustrating that ion channels in mast cell membranes can be activated by mechanical and red-laser-light stimuli. These stimuli can induce degranulation of the human mast cell line HMC1 as well as mast cells in connective tissue of rats. For HMC1 we also could show that the stimulation led to an increase in intracellular Ca2+. Activation of transient receptor potential channels sensitive to valinoid (TRPV) may be involved in initiation of the degranulation process. A stretch-activated anion channel may also be involved.
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Wang Lina, Sikora Jacek, Hu Lei, Shen Xueyong, Grygorczyk Ryszard, Schwarz Wolfgang, ATP Release from Mast Cells by Physical Stimulation: A Putative Early Step in Activation of Acupuncture Points, Evidence-Based Complementary and Alternative Medicine, 2013, 2013. Crossref
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Wang Lina, Hu Lei, Grygorczyk Ryszard, Shen Xueyong, Schwarz Wolfgang, Modulation of Extracellular ATP Content of Mast Cells and DRG Neurons by Irradiation: Studies on Underlying Mechanism of Low-Level-Laser Therapy, Mediators of Inflammation, 2015, 2015. Crossref
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Wang Lina, Zhang Di, Schwarz Wolfgang, TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy, Cells, 3, 3, 2014. Crossref
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Liddle Conner E., Harris Richard E., Cellular Reorganization Plays a Vital Role in Acupuncture Analgesia, Medical Acupuncture, 30, 1, 2018. Crossref
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Wang Li-Na, Wang Xue-Zhi, Li Yu-Jia, Li Bing-Rong, Huang Meng, Wang Xiao-Yu, Grygorczyk Ryszard, Ding Guang-Hong, Schwarz Wolfgang, Activation of Subcutaneous Mast Cells in Acupuncture Points Triggers Analgesia, Cells, 11, 5, 2022. Crossref
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Rettinger Jürgen, Schwarz Silvia, Schwarz Wolfgang, Examples of Application of the Voltage-Clamp Technique, in Electrophysiology, 2022. Crossref