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Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Spectrum of the Early Xenograft Response: From Hyperacute Rejection to Delayed Xenograft Injury

巻 27, 発行 2, 2007, pp. 153-166
DOI: 10.1615/CritRevImmunol.v27.i2.30
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要約

Hyperacute xenograft rejection is a well-defined barrier to clinical pig-to-human xenotransplantation, and intense research in this area has identified potential solutions. In contrast, the next phase of xenograft injury, which can occur days to weeks later, has introduced a new series of immunological and nonimmunological barriers with complex mechanisms. This review addresses mechanisms of the immediate and delayed xenograft response with a focus on the relevant components. The key individual elements include carbohydrate antigens and natural antibodies to these epitopes, the role of the complement and coagulation systems, and the inflammatory cellular xenograft response that is predominantly mediated by the innate immune system. The vascular elements are central targets in this process, and the role of the endothelial cell is discussed. Important recent developments in xenotransplantation include the production of genetically modified pigs (deficient in αGal transferase and pigs transgenic for complement regulators) and a progressive understanding of xenograft-induced thrombotic microangiopathy, which threatens the long-term survival of transplanted pig organs and tissue. However, a clear standardized classification of the immunopathological mechanisms involved is essential. Further studies into the delayed xenograft response, using primates, are required before the routine use of pig organs for clinical transplantation.

によって引用された
  1. YEOM Hye-Jung, SHIN Kum-Joo, KIM Jun-Sub, KIM Seung-Jun, LEE Sukmook, PAUL Saswati, HAN Jung-Won, AHN Curie, SEONG Je Kyung, CHUNG Junho, HWANG Seung Young, Porcine Aortic Endothelial Cell Genes Responsive to Selected Inflammatory Stimulators, Journal of Veterinary Medical Science, 71, 11, 2009. Crossref

  2. Simioni Paolo, Boldrin Massimo, Gavasso Sabrina, Seveso Michela, Radu Claudia, Bulato Cristiana, Calabrese Fiorella, Cavicchioli Laura, Bertini Diana, De Benedictis Giulia M., Besenzon Federica, Baldan Nicola, Spiezia Luca, Plebani Mario, Ancona Ermanno, Cozzi Emanuele, Effects of Long-Term Administration of Recombinant Human Protein C in Xenografted Primates, Transplantation, 91, 2, 2011. Crossref

  3. Vadori M., Cozzi E., The immunological barriers to xenotransplantation, Tissue Antigens, 86, 4, 2015. Crossref

  4. Zhang Junfang, Xie Chongwei, Lu Ying, Zhou Ming, Qu Zepeng, Yao Da, Qiu Chuanghua, Xu Jia, Pan Dengke, Dai Yifan, Hara Hidetaka, Cooper David K. C., Ma Shanshan, Li Mingtao, Cai Zhiming, Mou Lisha, Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model, Scientific Reports, 7, 1, 2017. Crossref

  5. Smith Kate E., Johnson Robert C., Papas Klearchos K., Update on cellular encapsulation, Xenotransplantation, 25, 5, 2018. Crossref

  6. Ramackers Wolf, Werwitzke Sonja, Klose Johannes, Friedrich Lars, Johanning Kai, Bergmann Sabine, Klempnauer Jürgen, Winkler Michael, Tiede Andreas, Investigation of the influence of xenoreactive antibodies on activation of complement and coagulation in anex vivoperfusion animal study using porcine kidneys, Transplant International, 32, 5, 2019. Crossref

  7. Ramackers Wolf, Rataj Dennis, Werwitzke Sonja, Bergmann Sabine, Winkler Michael, Wünsch Annegret, Bähr Andrea, Wolf Eckard, Klymiuk Nikolai, Ayares David, Tiede Andreas, Expression of human thrombomodulin on porcine endothelial cells can reduce platelet aggregation but did not reduce activation of complement or endothelium – an experimental study, Transplant International, 33, 4, 2020. Crossref

  8. Zhou Qiao, Li Ting, Wang Kaiwen, Zhang Qi, Geng Zhuowen, Deng Shaoping, Cheng Chunming, Wang Yi, Current status of xenotransplantation research and the strategies for preventing xenograft rejection, Frontiers in Immunology, 13, 2022. Crossref

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