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Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Mechanism of Activation-Induced Cell Death of T Cells and Regulation of FasL Expression

巻 34, 発行 4, 2014, pp. 301-314
DOI: 10.1615/CritRevImmunol.2014009988
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要約

Activation-induced cell death (AICD) of T cells is a process for regulating the peripheral immune system. The fate of a T cell is controlled by numerous signals derived from various stimuli, such as antigens, cytokines, and chemokines. In healthy humans, overactivated or autoreactive T cells are harmful and are eliminated to maintain the immune system. AICD in T cells by Fas/FasL-mediated apoptosis is triggered by the switch from life to death through several signaling molecules. The control or distribution of Fas or FasL expression largely affects AICD of T cells. Although autoimmune diseases are considered to be induced by multiple factors, an impaired immune system with AICD by Fas/FasL-mediated apoptosis leads to the onset or development of autoimmunity. Based on published reports, this review describes the regulatory mechanisms involved in AICD of T cells by Fas/ FasL-mediated apoptosis and the associations between AICD and autoimmunity in humans and animal models.

によって引用された
  1. Neumann Simon, El Maadidi Souhayla, Faletti Laura, Haun Florian, Labib Shirin, Schejtman Andrea, Maurer Ulrich, Borner Christoph, How do viruses control mitochondria-mediated apoptosis?, Virus Research, 209, 2015. Crossref

  2. Ge Rong-Ti, Zeng Lu, Mo Li-Hua, Xu Ling-Zhi, Zhang Huan-Ping, Yu Hai-Qiong, Zhang Min, Liu Zhi-Gang, Liu Zhan-Ju, Yang Ping-Chang, Interaction of TIM4 and TIM3 induces T helper 1 cell apoptosis, Immunologic Research, 64, 2, 2016. Crossref

  3. Plander Mark, Kalman Bernadette, Rare autoimmune disorders with Mendelian inheritance, Autoimmunity, 49, 5, 2016. Crossref

  4. Timilsina Uddhav, Gaur Ritu, Modulation of apoptosis and viral latency – an axis to be well understood for successful cure of human immunodeficiency virus, Journal of General Virology, 97, 4, 2016. Crossref

  5. Furlan Scott N., Watkins Benjamin, Tkachev Victor, Cooley Sarah, Panoskaltsis-Mortari Angela, Betz Kayla, Brown Melanie, Hunt Daniel J., Schell John B., Zeleski Katie, Yu Alison, Giver Cynthia R., Waller Edmund K., Miller Jeffrey S., Blazar Bruce R., Kean Leslie S., Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells, Blood, 128, 21, 2016. Crossref

  6. Wallach David, Kovalenko Andrew, Roles of TNF and Other Members of the TNF Family in the Regulation of Innate Immunity, in Encyclopedia of Immunobiology, 2016. Crossref

  7. Wang Hao, Zhang Xueyan, Sun Wenjing, Hu Xiaocui, Li Xiaolin, Fu Songbin, Liu Chen, Activation of TIM1 induces colon cancer cell apoptosis via modulating Fas ligand expression, Biochemical and Biophysical Research Communications, 473, 2, 2016. Crossref

  8. Jinesh Goodwin G., Mokkapati Sharada, Zhu Keyi, Morales Edwin E., Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks, Apoptosis, 21, 11, 2016. Crossref

  9. Lin Xu, Huang Haiting, You Yanwu, Tang Chunrong, Gu Xiangjun, Huang Meiying, Tan Junhua, Wang Jie, Activation of TLR5 induces podocyte apoptosis, Cell Biochemistry and Function, 34, 2, 2016. Crossref

  10. Carcillo Joseph A., Podd Bradley, Aneja Rajesh, Weiss Scott L., Hall Mark W., Cornell Timothy T., Shanley Thomas P., Doughty Lesley A., Nguyen Trung C., Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome, Pediatric Critical Care Medicine, 18, 2017. Crossref

  11. Martínez de Toda Irene, Vida Carmen, De la Fuente Mónica, An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity, International Journal of Molecular Sciences, 18, 7, 2017. Crossref

  12. Zhang Jin-yu, Zhao Yong-liang, Lv Yi-pin, Cheng Ping, Chen Weisan, Duan Mubin, Teng Yong-sheng, Wang Ting-ting, Peng Liu-sheng, Mao Fang-yuan, Liu Yu-gang, Fu Xiao-long, Yu Pei-wu, Luo Ping, Zhang Wei-jun, Zou Quan-ming, Zhuang Yuan, Modulation of CD8+ memory stem T cell activity and glycogen synthase kinase 3β inhibition enhances anti-tumoral immunity in gastric cancer, OncoImmunology, 7, 4, 2018. Crossref

  13. Pulido-Salgado Marta, Vidal-Taboada Jose M., Garcia Diaz-Barriga Gerardo, Serratosa Joan, Valente Tony, Castillo Paola, Matalonga Jonathan, Straccia Marco, Canals Josep M., Valledor Annabel, Solà Carme, Saura Josep, Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis, Journal of Neuroinflammation, 14, 1, 2017. Crossref

  14. Baer Alan, Colon-Moran Winston, Xiang Jinhua, Stapleton Jack T., Bhattarai Nirjal, Buday Laszlo, Src-family kinases negatively regulate NFAT signaling in resting human T cells, PLOS ONE, 12, 10, 2017. Crossref

  15. Yamada Akiko, Arakaki Rieko, Saito Masako, Kudo Yasusei, Ishimaru Naozumi, Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance, Frontiers in Immunology, 8, 2017. Crossref

  16. Cheng Qianqian, Liu Jian, Pei Yujun, Zhang Yaolin, Zhou Dawang, Pan Weiqing, Zhang Jiyan, Gazzinelli Ricardo T., Neddylation contributes to CD4+ T cell-mediated protective immunity against blood-stage Plasmodium infection, PLOS Pathogens, 14, 11, 2018. Crossref

  17. Hu Tianyong, Fan Xiaoqin, Ma Li, Liu Jiangqi, Chang Yunli, Yang Pingchang, Qiu Shuqi, Chen Tao, Yang Litao, Liu Zhiqiang, TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression, International Journal of Molecular Medicine, 40, 5, 2017. Crossref

  18. Agrawal Babita, Gupta Nancy, Konowalchuk Jeffrey D., MUC1 Mucin: A Putative Regulatory (Checkpoint) Molecule of T Cells, Frontiers in Immunology, 9, 2018. Crossref

  19. Kandouz Mustapha, Dying to communicate: apoptotic functions of Eph/Ephrin proteins, Apoptosis, 23, 5-6, 2018. Crossref

  20. Dong Bohan, Dai Guangli, Ding Yuanyuan, Wang Beiru, Zhang Siyuan, Vaccination with FasL-/TCL plus MHSP65 induces improved anti-lung cancer immunity in mice, International Immunopharmacology, 55, 2018. Crossref

  21. Mizui Masayuki, Natural and modified IL-2 for the treatment of cancer and autoimmune diseases, Clinical Immunology, 206, 2019. Crossref

  22. Bantia Shanta, Choradia Nirmal, Treatment duration with immune-based therapies in Cancer: an enigma, Journal for ImmunoTherapy of Cancer, 6, 1, 2018. Crossref

  23. Shin Sung-Young, Kim Min-Wook, Cho Kwang-Hyun, Nguyen Lan K., Coupled feedback regulation of nuclear factor of activated T-cells (NFAT) modulates activation-induced cell death of T cells, Scientific Reports, 9, 1, 2019. Crossref

  24. Liu Sai, Sun Jianping, Li Zhen, Qin Ling, Liu Guihai, Li Kang, Wu Hao, Dong Tao, Zhang Yonghong, T Cell Therapy Targeted on HLA-A02 Restricted HIV Antigen Epitopes: An Open Label Cellular Therapy Trial Using CD8+ T Cell, Frontiers in Immunology, 10, 2019. Crossref

  25. Gao Han, Feng Bai-Sui, Liu Jiang-Qi, Mo Li-Hua, Geng Xiao-Rui, Xiao Yuan, Zhang Yuan-Yi, Hong Jing-Yi, Liu Zhan-ju, Liu Zhi-Gang, Feng Yisheng, Yang Ping-Chang, Survivin induces defects in apoptosis in eosinophils in intestine with food allergy, Innate Immunity, 25, 4, 2019. Crossref

  26. Hall Bruce M., T Cells: Soldiers and Spies—The Surveillance and Control of Effector T Cells by Regulatory T Cells, Clinical Journal of the American Society of Nephrology, 10, 11, 2015. Crossref

  27. Low Michael Sze Yuan, Brodie Erica J., Fedele Pasquale L., Liao Yang, Grigoriadis George, Strasser Andreas, Kallies Axel, Willis Simon N., Tellier Julie, Shi Wei, Gabriel Sarah, O’Donnell Kristy, Pitt Catherine, Nutt Stephen L., Tarlinton David, IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis, Cell Reports, 29, 9, 2019. Crossref

  28. Kugyelka Réka, Prenek Lilla, Olasz Katalin, Kohl Zoltán, Botz Bálint, Glant Tibor, Berki Timea, Boldizsár Ferenc, ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis, Cells, 8, 5, 2019. Crossref

  29. Guram Kripa, Kim Sangwoo S., Wu Victoria, Sanders P. Dominick, Patel Sandip, Schoenberger Stephen P., Cohen Ezra E. W., Chen Si-Yi, Sharabi Andrew B., A Threshold Model for T-Cell Activation in the Era of Checkpoint Blockade Immunotherapy, Frontiers in Immunology, 10, 2019. Crossref

  30. Luo Xiang‐Qian, Ma Fei, Wang Shuai, Zhao Mei‐Zhen, Shao Jian‐Bo, Geng Xiao‐Rui, Liu Jiang‐Qi, Mo Li‐Hua, Guan Li, Liu Zhi‐Gang, Liu Da‐Bo, Yang Ping‐Chang, Interleukin‐5 induces apoptotic defects in CD4 + T cells of patients with allergic rhinitis , Journal of Leukocyte Biology, 105, 4, 2019. Crossref

  31. Yalinbaş Emine E., Sezgin Evim Melike, Bör Özcan, Gülbaş Zafer, Cytokine Profile, Apoptosis, Glucocorticoid Receptor, and P-glycoprotein Expression Before and After Megadose Methylprednisolone Treatment in Children With Acute Immune Thrombocytopenia, Journal of Pediatric Hematology/Oncology, 41, 7, 2019. Crossref

  32. Zhang Mei, Ming Siqi, Gong Sitang, Liang Siping, Luo Yuanmei, Liang Zibin, Cao Can, Lao Juanfeng, Shang Yuqi, Li Xingyu, Wang Manni, Zhong Guoquan, Xu Lingqing, Wu Minhao, Wu Yongjian, Activation-Induced Cell Death of Mucosal-Associated Invariant T Cells Is Amplified by OX40 in Type 2 Diabetic Patients, The Journal of Immunology, 203, 10, 2019. Crossref

  33. Xue Jin‐Mei, Zhao Mei‐Zhen, Ma Fei, Li Shan‐Shan, Mo Li‐Hua, Zeng Xian‐Hai, Wu Yong‐Jin, Liu Jiang‐Qi, Hu Tian‐Yong, Xie Rui‐Di, Liu Zhi‐Gang, Zhao Chang‐Qing, Yang Ping‐Chang, Survivin facilitates T‐helper 2–biased inflammation in the airway, International Forum of Allergy & Rhinology, 9, 6, 2019. Crossref

  34. Perez-Ruiz Elisabeth, Minute Luna, Otano Itziar, Alvarez Maite, Ochoa Maria Carmen, Belsue Virginia, de Andrea Carlos, Rodriguez-Ruiz Maria Esperanza, Perez-Gracia Jose Luis, Marquez-Rodas Ivan, Llacer Casilda, Alvarez Martina, de Luque Vanesa, Molina Carmen, Teijeira Alvaro, Berraondo Pedro, Melero Ignacio, Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy, Nature, 569, 7756, 2019. Crossref

  35. Jiao Juanjuan, Zhao Xincheng, Hou Ruixia, Wang Ying, Chang Wenjuan, Liang Nannan, Liu Yanmin, Xing Jianxiao, Cao Yue, Li Xiaofang, Zhang Kaiming, Comparison of two commonly used methods for stimulating T cells, Biotechnology Letters, 41, 12, 2019. Crossref

  36. Zhang Meng, Wang Jing, Jia Lingwei, Huang Jin, He Cheng, Hu Fuqing, Yuan Lifei, Wang Guihua, Yu Mingxia, Li Zhuoya, Transmembrane TNF-α promotes activation-induced cell death by forward and reverse signaling, Oncotarget, 8, 38, 2017. Crossref

  37. Liu Guihuan, Yu Yuming, Feng Fu, Zhu Ping, Zhang Hua, Zhang Danni, Feng Xiaoqiang, Zhang Zedan, Liu Yanjun, Human CD8+CD28− T suppressor cells expanded by common gamma chain (γc) cytokines retain steady allospecific suppressive capacity in vivo, BMC Immunology, 21, 1, 2020. Crossref

  38. Simula Luca, Corrado Mauro, Accordi Benedetta, Di Rita Anthea, Nazio Francesca, Antonucci Ylenia, Di Daniele Arianna, Caicci Federico, Caruana Ignazio, Soriano Maria Eugenia, Pigazzi Martina, Locatelli Franco, Cecconi Francesco, Campello Silvia, JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction, Cell Death & Differentiation, 27, 10, 2020. Crossref

  39. Peroumal Doureradjou, Abimannan Thiruvaimozhi, Tagirasa Ravichandra, Parida Jyothi Ranjan, Singh Santosh Kumar, Padhan Prasantha, Devadas Satish, Inherent low Erk and p38 activity reduce Fas Ligand expression and degranulation in T helper 17 cells leading to activation induced cell death resistance, Oncotarget, 7, 34, 2016. Crossref

  40. Liu Huashan, Liang Zhenxing, Wang Fengwei, Zheng Xiaobin, Zeng Ziwei, He Xiaowen, Gao Xiang, Zhi Min, Wu Xiaojian, Wu Xianrui, Lan Ping, Intestinal CD14+ Macrophages Protect CD4+ T Cells From Activation-induced Cell Death via Exosomal Membrane TNF in Crohn’s Disease, Journal of Crohn's and Colitis, 14, 11, 2020. Crossref

  41. Chen Xiao, Zhao Mei-Zhen, Miao Bei-Ping, Liu Zhi-Qiang, Yang Gui, Liu Jiang-Qi, Yang Ping-Chang, Song Jiang-Ping, Inhibition of Bcl2L12 Attenuates Eosinophilia-Related Inflammation in the Heart, Frontiers in Immunology, 11, 2020. Crossref

  42. Li Yongmei , Lin Lu , Wang Qingxi , Correlation of expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid in neonatal respiratory distress syndrome and prognosis, Experimental and Therapeutic Medicine, 2018. Crossref

  43. Corrado Mauro, Samardžić Dijana, Giacomello Marta, Rana Nisha, Pearce Erika L., Scorrano Luca, Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism, Cell Death & Differentiation, 28, 7, 2021. Crossref

  44. Ma Yunhan, Yan Guoliang, Guo Junjun, Li Fujun, Zheng Haiping, Wang Chenxi, Chen Yingyu, Ye Yuhan, Dai Helong, Qi Zhongquan, Zhuang Guohong, Berberine Prolongs Mouse Heart Allograft Survival by Activating T Cell Apoptosis via the Mitochondrial Pathway, Frontiers in Immunology, 12, 2021. Crossref

  45. Li Sicong, Liu Fang, Zhang Kai, Tong Yujia, Liu Xin, Posarelli Chiara, Research Progress on the Mechanism of Natural Product Ingredients in the Treatment of Uveitis, Journal of Immunology Research, 2021, 2021. Crossref

  46. Singh Aman P., Chen Wenbo, Zheng Xirong, Mody Hardik, Carpenter Thomas J., Zong Alice, Heald Donald L., Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T, CPT: Pharmacometrics & Systems Pharmacology, 10, 4, 2021. Crossref

  47. Janelle Valérie, Delisle Jean-Sébastien, T-Cell Dysfunction as a Limitation of Adoptive Immunotherapy: Current Concepts and Mitigation Strategies, Cancers, 13, 4, 2021. Crossref

  48. Ghahri-Saremi Navid, Akbari Behnia, Soltantoyeh Tahereh, Hadjati Jamshid, Ghassemi Saba, Mirzaei Hamid Reza, Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors, Frontiers in Immunology, 12, 2021. Crossref

  49. Yin Maureen, O’Neill Luke A. J., The role of the electron transport chain in immunity, The FASEB Journal, 35, 12, 2021. Crossref

  50. Künkele Annette, Johnson Adam J., Rolczynski Lisa S., Chang Cindy A., Hoglund Virginia, Kelly-Spratt Karen S., Jensen Michael C., Functional Tuning of CARs Reveals Signaling Threshold above Which CD8+ CTL Antitumor Potency Is Attenuated due to Cell Fas–FasL-Dependent AICD, Cancer Immunology Research, 3, 4, 2015. Crossref

  51. Kamiya Mari, Mizoguchi Fumitaka, Kawahata Kimito, Wang Dengli, Nishibori Masahiro, Day Jessica, Louis Cynthia, Wicks Ian P., Kohsaka Hitoshi, Yasuda Shinsuke, Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies, Nature Communications, 13, 1, 2022. Crossref

  52. Chen Xiao, Zeng Xian-Hai, Wang Mangyuan, Chen Liang, Zhang Ningning, Rao Man, Yang Ping-Chang, Song Jiangping, Bcl2-Like Protein 12 Is Required for the Aberrant T Helper-2 Polarization in the Heart by Enhancing Interleukin-4 Expression and Compromising Apoptotic Machinery in CD4+ T Cells, Circulation, 138, 22, 2018. Crossref

  53. Akane Kazuyuki, Kojima Seiji, Mak Tak W., Shiku Hiroshi, Suzuki Haruhiko, CD8 + CD122 + CD49d low regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity , Proceedings of the National Academy of Sciences, 113, 9, 2016. Crossref

  54. Versteven Maarten, Flumens Donovan, Campillo-Davó Diana, De Reu Hans, Van Bruggen Laura, Peeters Stefanie, Van Tendeloo Viggo, Berneman Zwi, Dolstra Harry, Anguille Sébastien, Hobo Willemijn, Smits Evelien, Lion Eva, Anti-Tumor Potency of Short-Term Interleukin-15 Dendritic Cells Is Potentiated by In Situ Silencing of Programmed-Death Ligands, Frontiers in Immunology, 13, 2022. Crossref

  55. Huan Tian, Chen Dongfeng, Liu Guodong, Zhang Hailing, Wang Xiaoyan, Wu Zhi, Wu Yan, Xu Qinggang, Yu Feng, Activation-induced cell death in CAR-T cell therapy, Human Cell, 35, 2, 2022. Crossref

  56. Spetz Johan, Presser Adam G., Sarosiek Kristopher A., T Cells and Regulated Cell Death, in Biology of T Cells - Part B, 342, 2019. Crossref

  57. Chen Xiaohong, Li Muxia, Li Dan, Luo Ting, Xie Yizhen, Gao Liang, Zhang Yifan, Chen Shaodan, Li Shunxian, Huang Guoxin, Li Wenzhi, Su Jiyan, Lai Xiaoping, Ethanol extract of Pycnoporus sanguineus relieves the dextran sulfate sodium-induced experimental colitis by suppressing helper T cell-mediated inflammation via apoptosis induction, Biomedicine & Pharmacotherapy, 127, 2020. Crossref

  58. Mizui Masayuki, Tsokos George C., Low-Dose IL-2 in the Treatment of Lupus, Current Rheumatology Reports, 18, 11, 2016. Crossref

  59. Zhu Maoshu, Ma Yunhan, Tan Kai, Zhang Liyi, Wang Zhaowei, Li Yongsheng, Chen Yingyu, Guo Junjun, Yan Guoliang, Qi Zhongquan, Thalidomide with blockade of co-stimulatory molecules prolongs the survival of alloantigen-primed mice with cardiac allografts, BMC Immunology, 21, 1, 2020. Crossref

  60. LaBelle Cody A., Zhang Raymond J., Hunsucker Sally A., Armistead Paul M., Allbritton Nancy L., Microraft arrays for serial‐killer CD19 chimeric antigen receptor T cells and single cell isolation , Cytometry Part A, 2022. Crossref

  61. Klimov Vladimir V., Immune Tolerance at a Glance, in Textbook of Allergen Tolerance, 2022. Crossref

  62. Rodrigues Daniel B., Moreira Helena R., Cerqueira Mariana T., Marques Alexandra P., Castro António G., Reis Rui L., Pirraco Rogério P., Highly tailorable gellan gum nanoparticles as a platform for the development of T cell activator systems, Biomaterials Research, 26, 1, 2022. Crossref

  63. Wang Mo-Xuan, Gao Shu-Yue, Yang Fan, Fan Run-Jia, Yang Qin-Na, Zhang Tian-Lan, Qian Nian-Song, Dai Guang-Hai, Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?, World Journal of Clinical Oncology, 13, 9, 2022. Crossref

  64. Huang Jiawen, Huang Xiaobing, Huang Juan, CAR-T cell therapy for hematological malignancies: Limitations and optimization strategies, Frontiers in Immunology, 13, 2022. Crossref

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