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Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

CD4+ T Cell Activation During the Newborn Period: Barriers Against and Pathways Toward Th1 Immunity

巻 38, 発行 1, 2018, pp. 1-15
DOI: 10.1615/CritRevImmunol.2018025016
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要約

During the period of transition from intrauterine to extrauterine life, the neonatal immune system must learn to rapidly identify pathogens while balancing pro-inflammatory, antimicrobial responses with immune regulation that allows for resolution of inflammation and limits responses to commensal organisms and benign environmental antigens. However, the naive immune system of neonates is presented with several barriers that limit robust proinflammatory immune responses. Specifically, epigenetic modifications to neonatal naive CD4+ T cells, heightened neonatal regulatory T cell frequency and function, and limitations in the co-stimulatory potential of neonatal antigen presenting cells restrict development of CD4+ T cells with a T-helper 1 type functional profile. This restriction likely contributes to the increased risk of severe infection observed during early life. New research, however, suggests that neonates are capable of utilizing unique compensatory mechanisms to circumvent these restrictions and generate T-helper 1 type immunity under some circumstances. Understanding how to manipulate the immune responses of young infants to optimize development of T-helper 1 type immunity is key to the development of immune-based treatments and prevention strategies for severe infections in this vulnerable population.

によって引用された
  1. Verhoeven David, Immunometabolism and innate immunity in the context of immunological maturation and respiratory pathogens in young children, Journal of Leukocyte Biology, 106, 2, 2019. Crossref

  2. Fedoseenko Marina V., Petrova Veronika A., Namazova-Baranova Leyla S., Prevalence of Allergic Diseases in Children Vaccinated Against Tuberculosis and Hepatitis B in the Early Neonatal Period: Literature Review, Pediatric pharmacology, 18, 5, 2021. Crossref

  3. Yu Hong-Ren, Hsu Te-Yao, Tsai Ching-Chang, Huang Hsin-Chun, Cheng Hsin-Hsin, Lai Yun-Ju, Lin Yu-Ju, Chen Chih-Cheng, Li Sung-Chou, Yang Kuender, The Functional DNA Methylation Signatures Relevant to Altered Immune Response of Neonatal T Cells with l-Arginine Supplementation, Nutrients, 13, 8, 2021. Crossref

  4. Dietert Rodney R., Coleman Margaret E., North D. Warner, Stephenson Michele M., Nourishing the Human Holobiont to Reduce the Risk of Non-Communicable Diseases: A Cow’s Milk Evidence Map Example, Applied Microbiology, 2, 1, 2021. Crossref

  5. Zhang Qianqian, Zhao Jiuru, Ni Meng, Shen Qianwen, Zhou Wenhao, Liu Zhiwei, Vitamin D3 reverses the transcriptional profile of offspring CD4+ T lymphocytes exposed to intrauterine inflammation, The Journal of Steroid Biochemistry and Molecular Biology, 221, 2022. Crossref

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