年間 6 号発行
ISSN 印刷: 1040-8401
ISSN オンライン: 2162-6472
Indexed in
DNA Vaccines
要約
DNA vaccination against infectious diseases has created a new field of applied molecular immunology. cDNAs for 'protective' protein epitopes can be inserted into vectors containing strong mammalian promoters for high expression. Here we discuss the mechanisms of DNA vaccination and the successful and sometimes unsuccessful applications of DNA vaccination to protect animals against many different viral, bacterial mycoplasmal, protozoal, and worm infections or infestations. DNA immunization has been used to prevent or inhibit tumor development and to inhibit IgE responses by diverting the immune response from Th2 to Th1 helper cell dominance. Advantages and disadvantages of a variety of routes of administration and methods of immunization discussed include the use of the 'gene gun', the delivery of genes by aerosols, and deliberate induction of injury to muscles prior to injection of DNA to enhance gene expression. Vaccination performed using DNA without knowing beforehand the protective epitopes, using 'expression library immunization', is discussed. While this field is bound to expand rapidly for future clinical applications, we try to point out potential pitfalls as well as advantages of this relatively new technology.
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Weintraub Andrej, Immunology of bacterial polysaccharide antigens, Carbohydrate Research, 338, 23, 2003. Crossref
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Wunderbaldinger Patrick, Bogdanov Alexei, Weissleder Ralph, New approaches for imaging in gene therapy, European Journal of Radiology, 34, 3, 2000. Crossref
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Ahmad Sarfraz, Casey Garrett, Cronin Michelle, Rajendran Simon, Sweeney Paul, Tangney Mark, O'Sullivan Gerald C., Induction of Effective Antitumor Response After Mucosal Bacterial Vector Mediated DNA Vaccination With Endogenous Prostate Cancer Specific Antigen, Journal of Urology, 186, 2, 2011. Crossref
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Gupta V.K., Rout P.K., Vihan V.S., Induction of immune response in mice with a DNA vaccine encoding outer membrane protein (omp31) of Brucella melitensis 16M, Research in Veterinary Science, 82, 3, 2007. Crossref
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He Xianghui, Tsang Tom C., Zhang Tong, Luo Phoebe, Harris David T., Antigen epitope-expressing cytokines for DNA immunization, Vaccine, 23, 16, 2005. Crossref
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Glinka Yelena, de Pooter Renée, Croze France, Prud'homme Gérald J., Regulatory cytokine production stimulated by DNA vaccination against an altered form of glutamic acid decarboxylase 65 in nonobese diabetic mice, Journal of Molecular Medicine, 81, 3, 2003. Crossref
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Murdin Andrew D., Dunn Pamela, Sodoyer Regis, Wang Joe, Caterini Judy, Brunham Robert C., Aujame Luc, Oomen Ray, Use of a Mouse Lung Challenge Model to Identify Antigens Protective againstChlamydia pneumoniaeLung Infection, The Journal of Infectious Diseases, 181, s3, 2000. Crossref
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Jin Jing, DNA immunization with fusion genes encoding different regions of hepatitis C virus E2 fused to the gene for hepatitis B surface antigen elicits immune responses to both HCV and HBV, World Journal of Gastroenterology, 8, 3, 2002. Crossref
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Da Silva Diane M., Eiben Gretchen L., Fausch Steven C., Wakabayashi Mark T., Rudolf Michael P., Velders Markwin P., Kast W. Martin, Cervical cancer vaccines: Emerging concepts and developments, Journal of Cellular Physiology, 186, 2, 2001. Crossref
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Kieber-Emmons Thomas, Monzavi-Karbassi Behjatolah, Wang Bin, Luo Ping, Weiner David B., Cutting Edge: DNA Immunization with Minigenes of Carbohydrate Mimotopes Induce Functional Anti-Carbohydrate Antibody Response, The Journal of Immunology, 165, 2, 2000. Crossref
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Iborra Salvador, Soto Manuel, Carrión Javier, Nieto Ana, Fernández Edgar, Alonso Carlos, Requena Jose M., The Leishmania infantum Acidic Ribosomal Protein P0 Administered as a DNA Vaccine Confers Protective Immunity to Leishmania major Infection in BALB/c Mice , Infection and Immunity, 71, 11, 2003. Crossref
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Dumonteil Eric, Escobedo-Ortegon Javier, Reyes-Rodriguez Norma, Arjona-Torres Arletty, Ramirez-Sierra Maria Jesus, Immunotherapy of Trypanosoma cruzi Infection with DNA Vaccines in Mice , Infection and Immunity, 72, 1, 2004. Crossref
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Thermet A., Robaczewska M., Rollier C., Hantz O., Trepo C., Deleage G., Cova L., Identification of Antigenic Regions of Duck Hepatitis B Virus Core Protein with Antibodies Elicited by DNA Immunization and Chronic Infection, Journal of Virology, 78, 4, 2004. Crossref
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Tuomanen E. I., Al-Mariri Ayman, Tibor Anne, Mertens Pascal, De Bolle Xavier, Michel Patrick, Godfroid Jacques, Walravens Karl, Letesson Jean-Jacques, Induction of Immune Response in BALB/c Mice with a DNA Vaccine Encoding Bacterioferritin or P39 of Brucella spp , Infection and Immunity, 69, 10, 2001. Crossref
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Zhu Dan, Mengyue Mengyue, Qimuge Aaodeng, Bilige Bilige, Baiyin Tegexi, Temuqile Temuqile, Chen Shana, Borjigen Siqin, Baigude Huricha, Yang Dezhi, Oral Delivery of SARS-CoV-2 DNA Vaccines Using Attenuated Salmonella typhimurium as a Carrier in Rat, Molecular Genetics, Microbiology and Virology, 37, 3, 2022. Crossref
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