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Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Thymus-Derived Signals Regulate Early T-Cell Development

巻 25, 発行 2, 2005, pp. 141-160
DOI: 10.1615/CritRevImmunol.v25.i2.40
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要約

T cells develop in the thymus from uncommitted progenitors under the influence of multiple soluble and membrane-associated factors that regulate the migration, survival, proliferation, and differentiation of progenitor thymocytes. The role of cytokines such as stem cell factor and IL-7 in this process is well established. However, several recent studies have demonstrated an important role for other soluble factors in T-cell development, including WNTs, bone morphogenetic proteins, and Hedgehog proteins. Other studies have clarified how chemokines regulate the migration of progenitor thymocytes at various stages of development. Furthermore, the Notch pathway has emerged as the critical inducer of T-lineage commitment and differentiation, and Notch ligands expressed by the thymic stroma likely provide essential developmental cues throughout early T-cell development. In this review, we discuss recent advances in our understanding of how thymus-derived signals regulate early T-cell development.

によって引用された
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