ライブラリ登録: Guest
Critical Reviews™ in Immunology

年間 6 号発行

ISSN 印刷: 1040-8401

ISSN オンライン: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Endothelial Cells as Key Determinants of the Tumor Microenvironment: Interaction with Tumor Cells, Extracellular Matrix and Immune Killer Cells

巻 30, 発行 6, 2010, pp. 529-545
DOI: 10.1615/CritRevImmunol.v30.i6.30
Get accessGet access

要約

Besides tumor cells, the tumor microenvironment harbors a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells. It is a complex and highly dynamic environment, providing very important cues to tumor development and progression. Tumor-associated endothelial cells play a key role in this process. On the one hand, they form tumor-associated (angiogenic) vessels through sprouting from locally preexisting vessels or recruitment of bone marrow-derived endothelial progenitor cells, to provide nutritional support to the growing tumor. On the other hand, they are the interface between circulating blood cells, tumor cells and the extracellular matrix, thereby playing a central role in controlling leukocyte recruitment, tumor cell behavior and metastasis formation. Hypoxia is a critical parameter modulating the tumor microenvironment and endothelial/tumor cell interactions. Under hypoxic stress, tumor cells produce factors that promote tumor angiogenesis, tumor cell motility and metastasis. Among these factors, VEGF, a main angiogenesis modulator, can also play a critical role in the control of immune tolerance. This review discusses some aspects of the role of endothelial cells within tumor microenvironment and emphasizes their interaction with tumor cells, the extracellular matrix and with immune killer cells. We will also address the role played by circulating endothelial progenitor cells and illustrate their features and mechanism of recruitment to the tumor microenvironment and their role in tumor angiogenesis.

によって引用された
  1. Pazo-Cid R. A., Lanzuela M., Esquerdo G., Pérez-Gracia J. L., Antón A., Amigo G., Trufero J. Martínez, García-Otín A. L., Martín-Duque P., Novel antiangiogenic therapies against advanced hepatocellular carcinoma (HCC), Clinical and Translational Oncology, 14, 8, 2012. Crossref

  2. Bagley Rebecca G., Rouleau Cecile, Weber William, Mehraein Khodadad, Smale Robert, Curiel Maritza, Callahan Michelle, Roy Andre, Boutin Paula, Martin Thia St., Nacht Mariana, Teicher Beverly A., Tumor endothelial marker 7 (TEM-7): A novel target for antiangiogenic therapy, Microvascular Research, 82, 3, 2011. Crossref

  3. Kieda Claudine, El Hafny-Rahbi Bouchra, Collet Guillaume, Lamerant-Fayel Nathalie, Grillon Catherine, Guichard Alan, Dulak Jozef, Jozkowicz Alicja, Kotlinowski Jerzy, Fylaktakidou Konstantina C., Vidal Aurélien, Auzeloux Philippe, Miot-Noirault Elisabeth, Beloeil Jean-Claude, Lehn Jean-Marie, Nicolau Claude, Stable tumor vessel normalization with pO2 increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment, Journal of Molecular Medicine, 91, 7, 2013. Crossref

  4. Hussain Muzammal, Javeed Aqeel, Ashraf Muhammad, Yuzhu Hou, Mukhtar Muhammad Mahmood, Multilevel pharmacological manipulation of adenosine–prostaglandin E2/cAMP nexus in the tumor microenvironment: A ‘two hit’ therapeutic opportunity, Pharmacological Research, 73, 2013. Crossref

  5. Clark Robert, Krishnan Venkatesh, Schoof Michael, Rodriguez Irving, Theriault Betty, Chekmareva Marina, Rinker-Schaeffer Carrie, Milky Spots Promote Ovarian Cancer Metastatic Colonization of Peritoneal Adipose in Experimental Models, The American Journal of Pathology, 183, 2, 2013. Crossref

  6. Singh Shivani, Kaur Harshaminder, WITHDRAWN: Tumor microenvironment: A review, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2013. Crossref

  7. Calvo Fernando, Sahai Erik, Cell communication networks in cancer invasion, Current Opinion in Cell Biology, 23, 5, 2011. Crossref

  8. Mahapatra Saswati, Young Charles Y. F., Kohli Manish, Karnes R. Jeffrey, Klee Eric W., Holmes Michael W., Tindall Donald J., Donkena Krishna Vanaja, Antiangiogenic Effects and Therapeutic Targets ofAzadirachta indicaLeaf Extract in Endothelial Cells, Evidence-Based Complementary and Alternative Medicine, 2012, 2012. Crossref

  9. Collet Guillaume, Skrzypek Klaudia, Grillon Catherine, Matejuk Agata, El Hafni-Rahbi Bouchra, Lamerant – Fayel Nathalie, Kieda Claudine, Hypoxia control to normalize pathologic angiogenesis: Potential role for endothelial precursor cells and miRNAs regulation, Vascular Pharmacology, 56, 5-6, 2012. Crossref

  10. Balamurugan Kuppusamy, HIF-1 at the crossroads of hypoxia, inflammation, and cancer, International Journal of Cancer, 138, 5, 2016. Crossref

  11. Sun Da-zhi, Jiao Jian-peng, Ju Da-wei, Ye Min, Zhang Xuan, Xu Jing-yu, Lu Ye, He Jin, Wei Pin-kang, Yang Ming-hui, Tumor interstitial fluid and gastric cancer metastasis: An experimental study to verify the hypothesis of “tumor-phlegm microenvironment”, Chinese Journal of Integrative Medicine, 18, 5, 2012. Crossref

  12. Collet Guillaume, Szade Krzysztof, Nowak Witold, Klimkiewicz Krzysztof, El Hafny-Rahbi Bouchra, Szczepanek Karol, Sugiyama Daisuke, Weglarczyk Kazimierz, Foucault-Collet Alexandra, Guichard Alan, Mazan Andrzej, Nadim Mahdi, Fasani Fabienne, Lamerant-Fayel Nathalie, Grillon Catherine, Petoud Stéphane, Beloeil Jean-Claude, Jozkowicz Alicja, Dulak Jozef, Kieda Claudine, Endothelial precursor cell-based therapy to target the pathologic angiogenesis and compensate tumor hypoxia, Cancer Letters, 370, 2, 2016. Crossref

  13. Lu Yu-Yin, Wang Jing-Jing, Zhang Xin-Ke, Li Wen-Bao, Guo Xiu-Li, 1118-20, an indazole diarylurea compound, inhibits hepatocellular carcinoma HepG2 proliferation and tumour angiogenesis involving Wnt/β-catenin pathway and receptor tyrosine kinases, Journal of Pharmacy and Pharmacology, 67, 10, 2015. Crossref

  14. Jiang Li, Nick Alpa M., Sood Anil K., Fundamental Principles of Cancer Biology: Does It Have Relevance to the Perioperative Period?, Current Anesthesiology Reports, 5, 3, 2015. Crossref

  15. Zhang Yu, Yu Li-Ke, Xia Ning, Evaluation of serum and pleural levels of endostatin and vascular epithelial growth factor in lung cancer patients with pleural effusion, Asian Pacific Journal of Tropical Medicine, 5, 3, 2012. Crossref

  16. Zibara Kazem, Awada Zahraa, Dib Leila, El-Saghir Jamal, Al-Ghadban Sara, Ibrik Aida, El-Zein Nabil, El-Sabban Marwan, Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo, Scientific Reports, 5, 1, 2015. Crossref

  17. Koeck Stefan, Zwierzina Marit, Huber Julia M., Bitsche Mario, Lorenz Edith, Gamerith Gabriele, Dudas Jozsef, Kelm Jens M., Zwierzina Heinz, Amann Arno, Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers, Immunobiology, 221, 5, 2016. Crossref

  18. DENG XINCHAO, ZHANG PING, LIANG TINGTING, DENG SUYE, CHEN XIAOJIE, ZHU LIN, Ovarian cancer stem cells induce the M2 polarization of macrophages through the PPARγ and NF-κB pathways, International Journal of Molecular Medicine, 36, 2, 2015. Crossref

  19. Cree Ian A, Improved blood tests for cancer screening: general or specific?, BMC Cancer, 11, 1, 2011. Crossref

  20. Skolekova Svetlana, Matuskova Miroslava, Bohac Martin, Toro Lenka, Durinikova Erika, Tyciakova Silvia, Demkova Lucia, Gursky Jan, Kucerova Lucia, Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells, Cell Communication and Signaling, 14, 1, 2016. Crossref

  21. Arias Jose-Ignacio, Aller Maria-Angeles, Prieto Isabel, Arias Ana, de Julian Zoe, Yang Heping, Arias Jaime, The Amazing Power of Cancer Cells to Recapitulate Extraembryonic Functions: The Cuckoo's Tricks, Journal of Oncology, 2012, 2012. Crossref

  22. 1 0 6, in Cancer Biomarkers, 2012. Crossref

  23. Paprocka Maria, Kieda Claudine, Kantor Aneta, Bielawska-Pohl Aleksandra, Dus Danuta, Czekanski Andrzej, Heimrath Jerzy, Increased Endothelial Progenitor Cell Number in Early Stage of Endometrial Cancer, International Journal of Gynecological Cancer, 27, 5, 2017. Crossref

  24. Klimkiewicz Krzysztof, Weglarczyk Kazimierz, Collet Guillaume, Paprocka Maria, Guichard Alan, Sarna Michal, Jozkowicz Alicja, Dulak Jozef, Sarna Tadeusz, Grillon Catherine, Kieda Claudine, A 3D model of tumour angiogenic microenvironment to monitor hypoxia effects on cell interactions and cancer stem cell selection, Cancer Letters, 396, 2017. Crossref

  25. XU YINGHUA, XIA XIAOPING, PAN HONGMING, Active autophagy in the tumor microenvironment: A novel mechanism for cancer metastasis, Oncology Letters, 5, 2, 2013. Crossref

  26. Choi Hyojeong, Moon Aree, Crosstalk between cancer cells and endothelial cells: implications for tumor progression and intervention, Archives of Pharmacal Research, 41, 7, 2018. Crossref

  27. Xin Xin, Yang Hopen, Zhang Fengli, Yang Shang-Tian, 3D cell coculture tumor model: A promising approach for future cancer drug discovery, Process Biochemistry, 78, 2019. Crossref

  28. Ura Blendi, Di Lorenzo Giovanni, Romano Federico, Monasta Lorenzo, Mirenda Giuseppe, Scrimin Federica, Ricci Giuseppe, Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice, International Journal of Molecular Sciences, 19, 12, 2018. Crossref

  29. Dürrbaum Milena, Storchová Zuzana, Consequences of Aneuploidy in Cancer: Transcriptome and Beyond, in Chromosomal Instability in Cancer Cells, 200, 2015. Crossref

  30. Paprocka Maria, Grillon Catherine, Duś Danuta, Kieda Claudine, Endothelium in Pathologic Angiogenesis and Angiogenesis-Mediated Therapies, in Angiogenesis and Vascularisation, 2013. Crossref

  31. Shi Wenyin, Siemann Dietmar W., Angiogenesis and Lung Cancer, in Advances in Radiation Oncology in Lung Cancer, 2011. Crossref

  32. Matos Ana I., Carreira Barbara, Peres Carina, Moura Liane I.F., Conniot João, Fourniols Thibaut, Scomparin Anna, Martínez-Barriocanal Águeda, Arango Diego, Conde João P., Préat Véronique, Satchi-Fainaro Ronit, Florindo Helena F., Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer, Journal of Controlled Release, 307, 2019. Crossref

  33. Audrito Valentina, Managò Antonella, Gaudino Federica, Sorci Leonardo, Messana Vincenzo Gianluca, Raffaelli Nadia, Deaglio Silvia, NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer, Frontiers in Immunology, 10, 2019. Crossref

  34. Zhang Tong, Sentman Charles L., Mouse Tumor Vasculature Expresses NKG2D Ligands and Can Be Targeted by Chimeric NKG2D-Modified T Cells, The Journal of Immunology, 190, 5, 2013. Crossref

  35. Mammoto Akiko, Mammoto Tadanori, Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration, Frontiers in Bioengineering and Biotechnology, 7, 2019. Crossref

  36. Lizárraga-Verdugo Erik, Avendaño-Félix Melisa, Bermúdez Mercedes, Ramos-Payán Rosalio, Pérez-Plasencia Carlos, Aguilar-Medina Maribel, Cancer Stem Cells and Its Role in Angiogenesis and Vasculogenic Mimicry in Gastrointestinal Cancers, Frontiers in Oncology, 10, 2020. Crossref

  37. Li Zhaohuan, Zheng Zengjuan, Li Chenglei, Li Zhipeng, Wu Jingliang, Zhang Bo, Therapeutic drugs and drug delivery systems targeting stromal cells for cancer therapy: a review, Journal of Drug Targeting, 28, 7-8, 2020. Crossref

  38. Zhang Qiuge, Wang Weiwei, Zhou Quanbo, Chen Chen, Yuan Weitang, Liu Jinbo, Li Xiaoli, Sun Zhenqiang, Roles of circRNAs in the tumour microenvironment, Molecular Cancer, 19, 1, 2020. Crossref

  39. Cabezas-Sáinz Pablo, Pensado-López Alba, Sáinz Bruno, Sánchez Laura, Modeling Cancer Using Zebrafish Xenografts: Drawbacks for Mimicking the Human Microenvironment, Cells, 9, 9, 2020. Crossref

  40. Gough Albert, Lezon Timothy, Faeder James R., Chennubhotla Chakra, Murphy Robert F., Critchley-Thorne Rebecca, Taylor D. Lansing, High-Content Analysis with Cellular and Tissue Systems Biology, in The Molecular Basis of Cancer, 2015. Crossref

  41. Liu Huan, Qiu Yikai, Pei Xiuying, Chitteti Ramamurthy, Steiner Rebbeca, Zhang Shuya, Jin Zheng Gen, Endothelial specific YY1 deletion restricts tumor angiogenesis and tumor growth, Scientific Reports, 10, 1, 2020. Crossref

  42. Najdaghi Soroush, Razi Sepideh, Rezaei Nima, An overview of the role of interleukin-8 in colorectal cancer, Cytokine, 135, 2020. Crossref

  43. Qiao Fuhao , Pan Peng , Yan Jiaping , Sun Jing , Zong Yan , Wu Zhiyong , Lu Xiaoqin , Chen Na , Mi Rui , Ma Yongbin , Ji Yuan , Role of tumor‑derived extracellular vesicles in cancer progression and their clinical applications (Review), International Journal of Oncology, 2019. Crossref

  44. Obermann Wolfgang M. J., Brockhaus Katrin, Eble Johannes A., Platelets, Constant and Cooperative Companions of Sessile and Disseminating Tumor Cells, Crucially Contribute to the Tumor Microenvironment, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  45. Akgol Sezer, Kalkan Batuhan Mert, Yucel Dogacan, Kocabas Fatih, SC1 limits tube formation, branching, migration, expansion and induce apoptosis of endothelial cells, Vascular Pharmacology, 141, 2021. Crossref

  46. Poggi Alessandro, Villa Federico, Fernadez Jordi Leonardo Castrillo, Costa Delfina, Zocchi Maria Raffaella, Benelli Roberto, Three-Dimensional Culture Models to Study Innate Anti-Tumor Immune Response: Advantages and Disadvantages, Cancers, 13, 14, 2021. Crossref

  47. Amer SamarI.I, Elesawy YasmineF, Eesa AhmedN, The expression of chitinase3-like1 in neovasculature of glioblastoma and some other gliomas, Egyptian Journal of Pathology, 40, 2, 2020. Crossref

  48. Yan Hongji, Hjorth Morgan, Winkeljann Benjamin, Dobryden Illia, Lieleg Oliver, Crouzier Thomas, Glyco-Modification of Mucin Hydrogels to Investigate Their Immune Activity, ACS Applied Materials & Interfaces, 12, 17, 2020. Crossref

  49. Zhuo Huiqin, Lyu Zhi, Su Jing, He Jian, Pei Yihua, Cheng Xiao, Zhou Nuo, Lu Xiaoling, Zhou Sufang, Zhao Yongxiang, Effect of Lung Squamous Cell Carcinoma Tumor Microenvironment on the CD105+ Endothelial Cell Proteome, Journal of Proteome Research, 13, 11, 2014. Crossref

  50. Kharaishvili Gvantsa, Simkova Dana, Bouchalova Katerina, Gachechiladze Mariam, Narsia Nato, Bouchal Jan, The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance, Cancer Cell International, 14, 1, 2014. Crossref

  51. Şimay Demir Yaprak Dilber, Özdemir Aysun, Sucularlı Ceren, Benhür Elifnur, Ark Mustafa, The implication of ROCK 2 as a potential senotherapeutic target via the suppression of the harmful effects of the SASP: Do senescent cancer cells really engulf the other cells?, Cellular Signalling, 84, 2021. Crossref

  52. Majewska Aleksandra, Wilkus Kinga, Brodaczewska Klaudia, Kieda Claudine, Endothelial Cells as Tools to Model Tissue Microenvironment in Hypoxia-Dependent Pathologies, International Journal of Molecular Sciences, 22, 2, 2021. Crossref

  53. Kang Youngnam, Datta Pallab, Shanmughapriya Santhanam, Ozbolat Ibrahim T., 3D Bioprinting of Tumor Models for Cancer Research, ACS Applied Bio Materials, 3, 9, 2020. Crossref

  54. Kejík Zdeněk, Kaplánek Robert, Dytrych Petr, Masařík Michal, Veselá Kateřina, Abramenko Nikita, Hoskovec David, Vašáková Martina, Králová Jarmila, Martásek Pavel, Jakubek Milan, Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design, Pharmaceutics, 13, 11, 2021. Crossref

  55. Dinh Huy Q., Pan Feng, Wang Geng, Huang Qing-Feng, Olingy Claire E., Wu Zhi-Yong, Wang Shao-Hong, Xu Xin, Xu Xiu-E, He Jian-Zhong, Yang Qian, Orsulic Sandra, Haro Marcela, Li Li-Yan, Huang Guo-Wei, Breunig Joshua J., Koeffler H. Phillip, Hedrick Catherine C., Xu Li-Yan, Lin De-Chen, Li En-Min, Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment, Nature Communications, 12, 1, 2021. Crossref

  56. Morbidelli Lucia, Donnini Sandra, Introduction, in Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy, 2022. Crossref

  57. Donnini Sandra, Filippelli Arianna, Ciccone Valerio, Spini Andrea, Ristori Emma, Ziche Marina, Morbidelli Lucia, Antiangiogenic drugs: Chemosensitizers for combination cancer therapy, in Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy, 2022. Crossref

  58. Kumar V.B. Sameer, Anjali K., Tumour generated exosomal miRNAs: A major player in tumour angiogenesis, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1868, 6, 2022. Crossref

  59. Gotink Kristy J., Broxterman Henk J., Labots Mariette, de Haas Richard R., Dekker Henk, Honeywell Richard J., Rudek Michelle A., Beerepoot Laurens V., Musters René J., Jansen Gerrit, Griffioen Arjan W., Assaraf Yehuda G., Pili Roberto, Peters Godefridus J., Verheul Henk M.W., Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance, Clinical Cancer Research, 17, 23, 2011. Crossref

  60. Hlatky Lynn, Hahnfeldt Philip, Beyond the Cancer Cell: Progression-Level Determinants Highlight the Multiscale Nature of Carcinogenesis Risk, Cancer Research, 74, 3, 2014. Crossref

  61. Sun Cui-cui, Zhang Yu-sheng, Xue Xia, Cheng Yan-na, Liu Hui-ping, Zhao Cui-rong, Lou Hong-xiang, Qu Xian-jun, Inhibition of angiogenesis involves in anticancer activity of riccardin D, a macrocyclic bisbibenzyl, in human lung carcinoma, European Journal of Pharmacology, 667, 1-3, 2011. Crossref

  62. Yang Jian, Hu Yong, Wang Lu, Sun Xiangran, Yu Ling, Guo Weichun, Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway, Bioengineered, 12, 2, 2021. Crossref

  63. Ma Yu‐Heng V., Lam Candy, Dalmia Shreyash, Gao Peter, Young Jacob, Middleton Kevin, Liu Chao, Xu Henry, You Lidan, Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling, Journal of Cellular Biochemistry, 119, 7, 2018. Crossref

  64. Collet Guillaume, Lamerant-Fayel Nathalie, Tertil Magdalena, El Hafny-Rahbi Bouchra, Stepniewski Jacek, Guichard Alan, Foucault-Collet Alexandra, Klimkiewicz Krzysztof, Petoud Stéphane, Matejuk Agata, Grillon Catherine, Jozkowicz Alicja, Dulak Jozef, Kieda Claudine, Hypoxia-Regulated Overexpression of Soluble VEGFR2 Controls Angiogenesis and Inhibits Tumor Growth, Molecular Cancer Therapeutics, 13, 1, 2014. Crossref

  65. Chaves K C B, Peron J P S, Chammas R, Turaça L T, Pesquero J B, Braga M S, Foguer K, Schor N, Bellini M H, Endostatin gene therapy stimulates upregulation of ICAM-1 and VCAM-1 in a metastatic renal cell carcinoma model, Cancer Gene Therapy, 19, 8, 2012. Crossref

  66. Paiva Ana E., Lousado Luiza, Guerra Daniel A.P., Azevedo Patrick O., Sena Isadora F.G., Andreotti Julia P., Santos Gabryella S.P., Gonçalves Ricardo, Mintz Akiva, Birbrair Alexander, Pericytes in the Premetastatic Niche, Cancer Research, 78, 11, 2018. Crossref

  67. Prasad Sahdeo, Saha Priyanka, Chatterjee Bilash, Chaudhary Anis Ahmad, Lall Rajiv, Srivastava Amit K, Complexity of Tumor Microenvironment: Therapeutic Role of Curcumin and Its Metabolites, Nutrition and Cancer, 2022. Crossref

  68. Najafi Alireza, Keykhaee Maryam, Khorramdelazad Hossein, Karimi Mohammad Yahya, Nejatbakhsh Samimi Leila, Aghamohamadi Nazanin, Karimi Milad, Falak Reza, Khoobi Mehdi, Catalase application in cancer therapy: Simultaneous focusing on hypoxia attenuation and macrophage reprogramming, Biomedicine & Pharmacotherapy, 153, 2022. Crossref

  69. Hu Wenxing, Lee Serene M. L., Bazhin Alexandr V., Guba Markus, Werner Jens, Nieß Hanno, Neutrophil extracellular traps facilitate cancer metastasis: cellular mechanisms and therapeutic strategies, Journal of Cancer Research and Clinical Oncology, 2022. Crossref

  70. Lai Qun, Li Wenqiang, Wang Hongping, Xu Siran, Deng Zhiping, Emerging role of circRNAs in cancer under hypoxia (Review), Oncology Letters, 24, 4, 2022. Crossref

近刊の記事

Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集 価格及び購読のポリシー Begell House 連絡先 Language English 中文 Русский Português German French Spain