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Critical Reviews™ in Therapeutic Drug Carrier Systems

年間 6 号発行

ISSN 印刷: 0743-4863

ISSN オンライン: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Self-Emulsifying Drug Delivery System (SEDDS): An Emerging Dosage Form to Improve the Bioavailability of Poorly Absorbed Drugs

巻 37, 発行 4, 2020, pp. 305-329
DOI: 10.1615/CritRevTherDrugCarrierSyst.2020033111
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要約

The main objective of drug(s) formulation is to enhance the bioavailability of the drug within the body. Some of the challenging issues associated with poorly water-soluble drugs concern solubility and bioavailability factors. To overcome these problems, new technologies, such as lipid-based drug delivery systems including micro or nano emulsifying drug delivery system, have gained importance in recent years, due to their enhanced solubility and bioavailability in the gastrointestinal tract. Such systems are incorporated or solubilized within the lipid excipients or mixed with oils or surfactants/co-solvents to facilitate the solubility and absorption rate, which can enhance the bioavailability of the targeted drug. This review provides a comprehensive summary about the properties, factors affecting formulations, excipients, formulation techniques, and characterization of self-emulsifying drug delivery systems. It also focuses on the new approaches concerned with SEDDS.

参考
  1. Gursoy RN, Benita S. Self-emulsifying drug delivery systems for improved oral delivery of lipophilic drugs. Biomed Pharmacother. 2004;58:173-82.

  2. Tang BC, Jian CG, Xu CH. Development of solid self-emulsifying drug delivery systems: Preparation techniques and dosage forms. Drug Discov Today. 2008;5(6):606-12.

  3. Shah VP, Amidon GL, Lennernas H, Crison JR. A theoretical basis for a biopharmaceutic drug clas-sification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res. 2014;12:894-88.

  4. Williams HD, Trevaskis NL, Charman SA, Shanker RM, Charman WN, Pouton CW, Porter CJH. Strategies to address low drug solubility in discovery and development. Pharmacol Rev. 2013; 65:315-499.

  5. Croy SR, Kwon GS. The effects of Pluronic block copolymers on the aggregation state of nystatin. J Control Release. 2004;95:161-71.

  6. Thi TD, Van Speybroeck M, Barillaro V, Martens J, Annaert P, Augustijns P, Humbeeck JV, Vermant J, Van den Mooter G. Formulate-ability of ten compounds with different physicochemical profiles in SMEDDS. Eur J Pharm Sci. 2009;38:479-88.

  7. Ajay K, Surabh S, Ravindra K. Self-emulsifying drug delivery systems (SEDDS): Future aspects. Int J Pharm Pharm Sci. 2019;2(4):7-13.

  8. Parmar N, Singla N, Amina S, Kohli K. Study of co-surfactant effect on nano emulsifying area and development of lercanidipine loaded (SNEDDS) self nano emulsifying drug delivery system. Colloids Surf B. 2011;86:327-38.

  9. Pouton CW. Lipid formulations for oral administration of drugs: Nonemulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur J Pharm Sci. 2000 Oct;11(Suppl 2): S93-8.

  10. Humberstone AJ, Charman WN. Lipid-based vehicles for the oral delivery of poorly water soluble drugs. Adv Drug Deliv Rev. 1997;25:103-28.

  11. Driscoll CMO. Lipid based formulations for intestinal lymphatic delivery. Eur J Pharm Sci. 2002;15:405-15.

  12. Charman WN, Porter CJ, Mithani S, Dressman JB. Physiochemical and physiological mechanisms for the effects of food on drug absorption: The role of lipids and pH. J Pharm Sci. 1997;86:269-82.

  13. Nekkanti V, Sandeep K. Development of novel lipid based drug delivery system for raloxifene hydro-chloride. Int Res J Pharm. 2012;3:166-73.

  14. Porter CJH, Charman WN. Uptake of drugs into intestinal lymphatics after oral administration. Adv Drug Deliv Rev. 1997;25:71-89.

  15. Pramod K, Peeyush K, Rajeev K, Nitish K, Rakesh K. An overview of lipid based formulation for oral drug delivery. Drug Inv Today. 2010;2:390-95.

  16. Erlanson-Albertsson C. Pancreatic colipase. Structural and physiological aspects. Biochim Biophys Acta. 1992;1125:1-7.

  17. Woo JS, Song YK, Hong JY, Lim SJ, Kim CK. Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers. Eur J Pharm Sci. 2008;33:59-65.

  18. Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. Self-emulsifying drug delivery system (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm. 1994;106:15-23.

  19. Constantinides PP. Lipid microemulsion for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects. Pharm Res. 1994;12:1561-72.

  20. Bowtle W. Materials, process, and manufacturing considerations for lipid-based hardcapsule formats. In: Hauss DJ, editor. Oral lipid-based formulations enhancing the bioavailability of poorly water-soluble drugs. Boca Raton: CRC Press; 2007.

  21. Rahman A, Hussain A, Hussain S, Mirza MA, Iqbal Z. Role of excipients in successful development of self-emulsifying/microemulsifying drug delivery system (SEDDS/ SMEDDS). Drug Dev Ind Pharm. 2012;39:1-19.

  22. Ku MS, Li W, Dulin W, Donahue F, Cade D, Benameur H, Hutchison K. Performance qualification of a new hypromellose capsule: Part I. Comparative evaluation of physical, mechanical and process-ability quality attributes of Vcaps Plus, QualiV and gelatin capsules. Int J Pharm. 2010;386:30-41.

  23. Wasylaschuk WR, Harmon PA, Wagner G, Harman AB, Templeton AC, Xu H, Reed RA. Evaluation of hydroperoxides in common pharmaceutical excipients. J Pharm Sci. 2007;96:106-116.

  24. Kshitija K, Swati M. Self-emulsifying drug delivery system: A review. Int J Pharm Sci and Res. 2013;4(12):4494-507.

  25. Patel PA, Chaulang GM, Akolkotkar A, Mutha SS, Hardikar S, Bhosale AV. Self-emulsifying drug delivery system: A review. RJPT. 2008;1(4):313-23.

  26. Pouton CW. Lipid formulations for oral administration of drugs non-emulsifying, self-emulsifying and self-micro emulsifying drug delivery systems. Eur J Pharm Sci. 2000;11(Suppl 2):S93-8.

  27. Kimura M, Shizuki M, Miyoshi K, Sakai T, Hidaka H, Takamura H, Matoba T. Relationship between the molecular structures and emulsification properties of edible oils. Biotech Biochem. 1994;58:1258-61.

  28. Pouton CW, Porter CJ. Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies. Adv Drug Deliv Rev. 2008;60(6):625-37.

  29. Memvanga PB, Veronique P. Formulation design and in vivo antimalarial evaluation of lipid-based drug delivery systems for oral delivery of beta-arteether. Eur J Pharm Biopharm. 2012; 82(1):112-9.

  30. Singh B, Bandopadhyay S, Kapil R, Singh R, Katare OP. Self-emulsifying drug delivery systems (SEDDS): Formulation development, characterization, and applications. Crit Rev Thera Drug Carr Syst. 2009;26(5):427-521.

  31. Swenson ES, Milisen WB, Curatolo W. Intestinal permeability enhancement: Efficacy, acute local toxicity, and reversibility. Pharm Res. 1994;11(8):1132-42.

  32. Wakerly MG, Pouton CW, Meakin BJ, Morton FS. Self-emulsification of vegetable oil-non-ionic surfactant mixtures. ACS Symposium Series 1986;311:242-55.

  33. Wang L, Dong J, Chen J, Eastoe J, Li X. Design and optimization of a new self-nanoemulsifying drug delivery system. J Colloid Interface Sci. 2009;330(2):443-8.

  34. Kommuru TR, Gurley B, Khan MA, Reddy IA. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: Formulation development and bioavailability assessment. Int J Pharm. 2001;212(2):233-46.

  35. Maurya S, Arya R, Rajpal G, Dhakar R. Self-micro emulsifying drug delivery systems (SMEDDS): A review on physico-chemical and biopharmaceutical aspects. JDDT. 2017;7(3):55.

  36. Craig DQ, Barkar SA, Banning D, Booth SW. An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int J Pharm. 1995;144:103-10.

  37. Porter CJ, Charman WN. In vitro assessment of oral lipid based formulations. Adv Drug Deliv Rev. 2001;50(Suppl 1):S127-47.

  38. Pillay V, Fassihi R. Unconventional dissolution methodologies. J Pharm Sci. 1999;88:9843-51.

  39. Joshi M, Pathak S, Sharma S, Patravale V. Solid microemulsion preconcentrate (NanOsorb) of arte-mether for effective treatment of malaria. Int J Pharm. 2008;362(1-2):172-8.

  40. Spernath A, Aserin A. Microemulsions as carriers for drugs and nutraceuticals. Adv Colloid Interface Sci. 2006;128:47-64.

  41. Sweetman SC, editor. Martindale: The complete drug reference. 36th ed. London: Pharmaceutical Press; 2009.

  42. Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Cel Ma MJ. Nano-emulsions. Curr Opin Colloid Interface Sci. 2005;10(3-4):102-10.

  43. Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects. Pharm Res. 1995;12(11):1561-72.

  44. Rang MJ, Miller CA. Spontaneous emulsification of oils containing hydrocarbon, nonionic surfactant and oleyl alcohol. J Colloid Interface Sci. 1999;209:179-2.

  45. Shi S, Yang L, Yao Q, Li X, Ming Y, Zhao Y. Ascorbic palmitate as a bifunctional drug and nanocarrier of paclitaxel for synergistic anti-tumor therapy. J Biomed Nanotechnol. 2018;194(9):1601-12.

  46. Murty RB, Murty SB, inventor; Murty Pharmaceuticals, Inc., assignee. Improved delivery of tetrahy-drocannabinol. WIPO (PCT) patent WO 2007056242A1. 2006 Nov 3.

  47. Gupta S, Kesarla R, Abdelwahab O. Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self-emulsifying systems. ISRN Pharm. 2013 Dec 26;2013:848043.

  48. Reiss H. Entropy-induced dispersion of bulk liquids. J Colloids Interface Sci. 1975;53:61-70.

  49. Dabros T. Emulsification through area contraction. J Colloids Interface Sci. 1999;210: 222-30.

  50. Yi X, Wan J, Xu H, Yang X. A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. Eur J Pharm Biopharm. 2008;70:439-44.

  51. Kallakunta VR, Bandari S, Jukanti R, Veerareddy PR. Oral self-emulsifying powder of lercanidipine hydrochloride: Formulation and evaluation. Powder Technol. 2012;221:375-82.

  52. Verreck G, Brewster ME. Melt extrusion-based dosage forms: Excipients and processing conditions for pharmaceutical formulations. Bull Tech Gattefosse. 2004;97:85-95.

  53. Wang Z, Sun J, Liu X, Liu Y, Fu Q, Meng P, He Z. Solid self-emulsifying nitrendipine pellets: Preparation and in vitro/in vivo evaluation. Int J Pharm. 2010;38:1-6.

  54. Hu X, Lin C, Chen D, Zhang J, Liu Z, Wu W, Song H. Sirolimus solid self-microemulsifying pellets: Formulation development, characterization and bioavailability evaluation. Int J Pharm. 2012;438:123-33.

  55. Julianto T, Yuen KH, Noor AM. Improved bioavailability of vitamin E with a self-emulsifying formu-lation. Int J Pharm. 2000;200:53-7.

  56. Kommuru TR, Gurley B, Khan MA, Reddy IK. Self-emulsifying drug delivery systems (SEDDS) of co-enzyme Q10: Formulation development and bioavailability assessment. Int J Pharm. 2001;212:233-46.

  57. Wasan KM. Formulation and physiological and biopharmaceutical issues in the development of oral lipid-based drug delivery systems. Drug Dev Ind Pharm. 2001;27:267-76.

  58. Lipinski CA. Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods. 2003;44:235-49.

  59. Jannin V, Musakhanian J, Marchaud D. Approaches for the development of solid and semisolid lipid-based formulations. Adv Drug Deliv Rev. 2008;60:734-46.

  60. Tang B, Cheng G, Gu JC, Xu CH. Development of solid self-emulsifying drug delivery systems: Preparation techniques and dosage forms. Drug Discov Today. 2008;13:606.

  61. Freeze-Thaw Stability Testing [homepage on the Internet]. Available from: https://microchemlab. com/test/freeze-thaw-stability-testing.

  62. Kamble VA, Jagdale DM, Kadam VJ. Self-micro emulsifying drug delivery system. Int J Pharm Bio Sci. 2010;1:1-9.

  63. Craig DQM, Barker SA, Banning D, Booth SW. An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int J Pharm. 1995;114(1):103-10.

  64. Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. Self-emulsifying drug delivery systems (SEDDS)with polyglycolized glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm. 1994;106:15-23.

  65. Gershanik T, Benita S. Positively charged self-emulsifying oil formulation for improving oral bio-availability of progesterone. Pharm Dev Technol. 1996;1(2):147-57.

  66. Serajuddin ATM, Shee PC, Mufson D, Augustine MA. Effect of vehicle amphiphilicity on the dissolution and bioavailability of poorly water-soluble drug from solid dispersion. J Pharm Sci. 1988;77:414-7.

  67. Rouffer MT, inventor; Accucaps Industries Ltd., assignee. Self-emulsify ibuprofen solution and soft gelatin capsule for use therewith. United States Patent US6221391B1. 1998 Nov 23.

  68. Gandhi R. Extrusion and spheronization in the development of oral controlled release dosage forms. Pharm Sci Technolo Today. 1999;4(2):160-70.

  69. Eckstein-Ludwig U, Webb RJ, Van Goethem ID, East JM, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S. Artemisinins targets the SERCA of Plasmodium falciparum. Nature. 2003;424(6951):957-61.

  70. Hamdani J. Physical and thermal characterizations of Precirol1 and Compritol1 as lipophilic glycerides used for the preparation of controlled release matrix pellets. Int J Pharm. 2003;260:47-57.

  71. Attama AA, Nkemnele MO. In vitro evaluation of drug release from self-micro-emulsifying drug delivery systems using a biodegradable homolipid from Capra hircus. Int J Pharm. 2005;304:4-10.

  72. Takada K, Murakami M, inventor; Amato Pharmaceutical Products Ltd., assignee. Glycyrrhizin preparations for transmucosal absorption. European Patent Office patent EP1236472A1. 2000 Jul 13.

  73. Kim JY, Ku YS. Enhanced absorption of indomethacin after oral or rectal administration of a self-emulsifying system containing indomethacin to rats. Int J Pharm. 2000;194:81-9.

  74. Loomis GL, inventor; Lifeshield Sciences LLC., assignee. Bioresorbable compositions for implantable prostheses. United States Patent US 6403758B1. 1999 Nov 8.

  75. Pouton CW. Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci. 2006;29(3-4):278-87.

  76. Patil P, Paradkar A. Porous polystyrene beads as carriers for self-emulsifying system containing loratadine. AAPS Pharm Sci Tech. 2006;7:E199-205.

  77. You J, Cui FD, Han X, Wang YS, Yang L, Yu YW, Li QP. Study of the preparation of sustained release microspheres containing zedoary turmeric oil by the emulsion-solvent diffusion method and evaluation of the self-emulsification and bioavailability of the oil. Colloids Surf B Biointerfaces. 2006;48(1):35-41.

  78. Bong Y, Yoo K, Hee J, inventors; Meditip Co., Ltd., assignee. Oral pharmaceutical composition containing lutein using self microemulsion system. South Korea Patent KR101213107B1. 2010 Jul 14.

  79. Kanchan K, Sunny C, Saurabh A, Roop KK, Kolappa KP, inventors; Arbro Pharmaceuticals Ltd. (New Delhi, IN), Jamia Hamdard (Hamdard University) (New Delhi, IN)., assignee. Self-emulsifying drug delivery system for curcuminoid based composition. United States Patent US20110294900A1. 2011 Apr 26.

  80. Hongda M, Tao G, inventors; Ma Hongda, assignee. Rhizoma corydalis totals alkaloids self-emulsifying drug delivery system and preparation method and application thereof. China Patent CN101912447B. 2010 Jul 30.

  81. Jianfeng W, Ming G, Dajun Y, Yanqiong L, inventors; Shanghai Yasheng Pharmaceutical Technology Co., Ltd., assignee. Apogossypolone self-emulsifying drug delivery system and preparation method thereof. China patent CN102247321A. 2010.

  82. Subin X, Xiaodong Y, Liu ZF, Li RJ, inventors; Zhejiang University of Technology, assignee. Novel curcumin self-emulsifying drug delivery system and preparation thereof. China Patent CN101627969A. 2009.

  83. Murty RB, Murty SB, inventor; Murty Pharmaceuticals Inc., assignee. Delivery of tetrahydrocannabinol: A self emulsifying drug delivery system to improve dissolution, stability, and bioavailability of drug compounds of dronabinol or other cannabinoids. United States patent US 2007104741. 2006.

  84. Mansoor AK, Sami N, inventor; Jarrow Formulas Inc., assignee. Eutectic-based self-nanoemulsified drug delivery system. Unites States patent US7588786B2. 2002 Nov 14.

  85. Nakhat P, Mandaogade P, inventor; Wockhardt Ltd., assignee. Self-emulsifying pharmaceutical compositions of Rhein or Diacerein. European Patent Office patent EP2207531B1. 2008.

  86. Li G, Chen Y, inventor; Tongji Medical College of Huazhong University of Science and Technology, assignee. Vinpocetine oral self-micro emulsification medicine releasing system and preparation method thereof. China patent CN101103962A. 2008.

  87. Weisspapir M, Schwarz J, inventor; Alpharx Inc., assignee. Solid self nano emulsifying controlled release drug delivery system composition for enhanced delivery of water insoluble phytosterols and other hydrophobic natural compound for body weight and cholesterol level control. United States patent US20020103139A1. 2002 Aug 1.

  88. Rajesh BV, Reddy TK, Srikanth G, Mallikarjun V. Lipid based self-emulsifying drug delivery system for poorly water soluble drugs, a review: An overview. J of Global Pharma Tech. 2010;2(3):47-55.

  89. Harborne JB, Williams CA. Advances in flavonoid research since 1992. Phytochemistry. 1992; 55:481-504.

  90. Ross JA, Kasum CM. Dietary flavonoids: Bioavailability, metabolic effects, and safety. Annu Rev Nutr. 2002;22:19-34.

  91. Yao LH, Jiang YM, Shi J, Tomas-Barberan FA, Datta N, Singanusong R, Chen SS. Flavonoids in food and their health benefits. Plant Foods Hum Nutr. 2004;59(3):113-22.

  92. Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships. J Nutr Biochem. 2002;13(10):572-84.

  93. Manach C, Williamson G, Morand C, ScalbertA, Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. review of 97 bioavailability studies. Am J Clin Nutr. 2005;81(Suppl 1):230S-242S.

  94. Stahl W, Van den Berg H, Arthur J, Bast A, Dainty J, Faulks RM, Gartner C, Haenen G, Hollman P, Holst B, Kelly FJ, Polidori MC, Rice-Evans C, Southon S, Vliet T, Vina-Ribes J, Williamson G, Astley SB. Bioavailability and mMetabolism. Mol Aspects Med. 2002;23(1-3):39-100.

  95. Thanki K, Gangwal RLP, Sangamwar AT, Jain S. Oral delivery of anticancer drugs: Challenges and opportunities. J Control Release. 2013;170(1):15-40.

  96. Anna RB, Benedetta I, Chiara R, Clizia G, Maria CB. Flavonoids loaded in nanocarriers: An opportunity to increase oral bioavailability and bioefficacy. Food Nutr Sci. 2014;5(13):1212-327.

  97. Mekjaruskul C, Yang YT, Leed MG, Sadgrove MP, Jay M, Sripanidkulchai B. Novel formulation strategies for enhancing oral delivery of methoxyflavones in Kaempferia parviflora by SMEDDS or complexation with 2-hydroxypropyl-beta-cyclodextrin. Int J Pharm. 2013;445(1-2):1-11.

  98. Zhao L, Du J, Duan Y, Zang Y, Zhang H, Yang C, Cao F, Zhai G. Curcumin loaded mixed micelles composed of Pluronic P123 and F68: Preparation, optimization and in vitro characterization. Colloids Surf B Biointer. 2012;97:101-8.

  99. Zhao Y, Wang C, Chow AH, Ren K, Gong T, Zhang Z, Zheng Y. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies. Int J Pharm. 2012;383:170-7.

  100. Shen Q, Li X, Yuan D, Jia W. Enhanced oral bioavailability of daidzein by self-microemulsifying drug delivery system. Chem Pharm Bull (Tokyo). 2012;58:639-643.

  101. Li W, Yi S, Wang Z, Chen S, Xin S, Xie J, Zhao C. Self-nanoemulsifying drug delivery system of persimmon leaf extract: Optimization and bioavailability studies. Int J Pharm. 2011;420(1):161-71.

  102. Liu W, Tian R, Hu W, Jia Y, Jiang H, Zhang J. Preparation and evaluation of self-micro emulsifying drug delivery system of baicalein. Fitoterapia. 2012;83:1532-39.

  103. Cui J, Yu B, Zhao Y, Zhu W, Li H, Lou H, Zhai G. Enhancement of oral absorption of curcumin by self-micro emulsifying drug delivery systems. Int J Pharm. 2009;371:148-55.

  104. Zhao L, Zhang L, Meng L, Wang J, Zhai G. Design and evaluation of a self-microemulsifying drug delivery system for apigenin. Drug Dev Ind Pharm. 2013;39(5):662-9.

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