年間 4 号発行
ISSN 印刷: 0893-9675
ISSN オンライン: 2162-6448
Indexed in
Myc Protein: Partners and Antagonists
要約
One of the first oncogenes identified from human tumors was c-myc, which is frequently activated in Burkitt's lymphomas due to chromosomal translocations. Subsequently, members of the myc oncogene family were found to be amplified in neuroblastoma and small-cell lung cancer. In normal cells, Myc activity has been shown to be both necessary and sufficient for resting cells to enter the cell cycle. Interestingly, it appears that Myc not only drives the cell cycle, but also induces cell death by apoptosis in certain situations. Myc contains a transcriptional activation domain and a basic helix-loop-helix-leucine zipper DNA-binding and dimerization domain. As a heterodimer with a structurally related protein, Max, Myc can bind DNA in a sequence-specific manner. These results suggest that the Myc/Max heterodimer functions as a transcriptional activator of genes that are critical for the regulation of cell growth.
-
Schlagbauer-Wadl Hermine, Griffioen Marieke, van Elsas Andrea, Schrier Peter I., Pustelnik Tom, Eichler Hans-Georg, Wolff Klaus, Pehamberger Hubert, Jansen Burkhard, Influence of Increased c-Myc Expression on the Growth Characteristics of Human Melanoma, Journal of Investigative Dermatology, 112, 3, 1999. Crossref
-
Borrè Aldo, Cultraro Constance M., Segal Shoshana, c-Myc inactivation by mutant max alters growth and morphology of NCI-H-630 colon cancer cells, Journal of Cellular Physiology, 169, 1, 1996. Crossref
-
Wolf Judith K., Ramirez Pedro T., The Molecular Biology of Cervical Cancer, Cancer Investigation, 19, 6, 2001. Crossref
-
Jussila Tommi, Mäkinen Markus, Stenbäck Frej, Oncogenes and growth factors as indicators of carcinogen exposure, Experimental and Toxicologic Pathology, 48, 2-3, 1996. Crossref
-
Rudolph Claudia, Adam Gerold, Simm Andreas, Determination of Copy Number of c-Myc Protein per Cell by Quantitative Western Blotting, Analytical Biochemistry, 269, 1, 1999. Crossref
-
Rudolph Claudia, Halle Jörn-Peter, Adam Gerold, Accelerated Proliferative Senescence of Rat Embryo Fibroblasts after Stable Transfection of Multiple Copies of the c-Myc DNA-Binding Sequence, Experimental Cell Research, 239, 2, 1998. Crossref
-
Wolff Linda, Contribution of oncogenes and tumor suppressor genes to myeloid leukemia, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1332, 3, 1997. Crossref
-
Sun Yu, Clark Edward A., Expression of the c-myc Proto-oncogene Is Essential for HIV-1 Infection in Activated T Cells, Journal of Experimental Medicine, 189, 9, 1999. Crossref
-
Akiyama Hideo, Kanai Shozo, Hirano Masahiko, Kumei Yasuhiro, shimokawa Hitoyata, Katano Hisako, Hara Eiji, Song Shuolin, Mukai Chiaki, Nagaoka Shunji, An improved quantitative RT-PCR fluorescent method for analysis of gene transcripts in the STS-65 space shuttle experiment, Journal of Biotechnology, 47, 2-3, 1996. Crossref
-
Arany Istvan, Tyring Stephen K., Status of Cytokine and Antigen Presentation Genes in Merkel Cell Carcinoma of the Skin, Journal of Cutaneous Medicine and Surgery, 2, 3, 1998. Crossref
-
BRYSK MIRIAM M., SELVANAYAGAM PETER, ARANY ISTVAN, BRYSK HENRY, TYRING STEPHEN K., RAJARAMAN SRINIVASAN, Induction of Apoptotic Nuclei by Interferon-γ and by Predesquamin in Cultured Keratinocytes, Journal of Interferon & Cytokine Research, 15, 12, 1995. Crossref
-
Varughese Mini, Chi Angela, Teixeira Avelino V., Nicholls Peter J., Keith Jerry M., Leppla Stephen H., Internalization of a Bacillus anthracis Protective Antigen-c-Myc Fusion Protein Mediated by Cell Surface Anti-c-Myc Antibodies, Molecular Medicine, 4, 2, 1998. Crossref
-
Haines Bryan P., Voyle Roger B., Rathjen Peter D., Raff Martin, Intracellular and Extracellular Leukemia Inhibitory Factor Proteins Have Different Cellular Activities That Are Mediated by Distinct Protein Motifs, Molecular Biology of the Cell, 11, 4, 2000. Crossref
-
Jhingran Anuja, Rodriguez Ana M., Neoplasms of the Cervix, in Holland‐Frei Cancer Medicine, 2019. Crossref
-
Klefstrom Juha, Saksela Eero, Alitalo Kari, Molecular Mechanisms Controlling Susceptibitliy to Tumor Necrosis Factor Induced Cell Death, in Tumor Biology, 1996. Crossref
-
O'Leary J J, Landers R J, Crowley M, Healy I, Kealy W F, Hogan J, Doyle C T, Alterations in exon 1 of c-myc and expression of p62c-myc in cervical squamous cell carcinoma., Journal of Clinical Pathology, 50, 11, 1997. Crossref
-
Amaral-Mendes J. J., Pluygers E., Use of Biochemical and Molecular Biomarkers for Cancer Risk Assessment in Humans, in Perspectives on Biologically Based Cancer Risk Assessment, 1999. Crossref
-
Veronese Maria Luisa, Bullrich Florencia, Croce Carlo M., Oncogenes and Mammary Carcinogenesis, in Endocrinology of Breast Cancer, 1999. Crossref
-
Kaptein John S., Lin Ching-Kow E., Wang C. Linzhi, Nguyen Tam Thuan, Kalunta Cosmas I., Park Eunhee, Chen Fun-Shan, Lad Pramod M., Anti-IgM-mediated Regulation of c-myc and Its Possible Relationship to Apoptosis, Journal of Biological Chemistry, 271, 31, 1996. Crossref
-
Kispal Gyula, Steiner Harald, Court Deborah A., Rolinski Boris, Lill Roland, Mitochondrial and Cytosolic Branched-chain Amino Acid Transaminases from Yeast, Homologs of the myc Oncogene-regulated Eca39 Protein, Journal of Biological Chemistry, 271, 40, 1996. Crossref
-
Thompson E. Brad, THE MANY ROLES OF c-Myc IN APOPTOSIS, Annual Review of Physiology, 60, 1, 1998. Crossref
-
Nakazawa Atsuko, Biological categories of neuroblastoma based on the international neuroblastoma pathology classification for treatment stratification, Pathology International, 71, 4, 2021. Crossref
-
c-Myc, in Leong's Manual of Diagnostic Antibodies for Immunohistology, 2016. Crossref
-
Dang Chi V., c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism, Molecular and Cellular Biology, 19, 1, 1999. Crossref