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Critical Reviews™ in Oncogenesis

年間 4 号発行

ISSN 印刷: 0893-9675

ISSN オンライン: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Single-Cell Gel (Comet) Assay as a Promising Tool for the Detection of DNA Damage Induced by Compounds Used in Dental Practice: The Oral Cancer Risk Assessment

巻 14, 発行 2-3, 2008, pp. 165-175
DOI: 10.1615/CritRevOncog.v14.i2-3.20
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要約

Taking into consideration genetic damage plays an important role in oral carcinogenesis, the purpose of this article is to provide an overview on the application of single-cell gel (comet) assay as a promising tool for the detection of DNA damage induced by some compounds used in dental practice as far as to assess the oral cancer risk. The single-cell gel (comet) assay is a microgel electrophoresis technique able to detect DNA damage at the level of single cells. In the alkaline version, which is mainly used, DNA single-strand breaks, DNA double-strand breaks, alkali-labile sites, and single-strand breaks containing incomplete excision repair sites cause increased DNA migration. Therefore, this interesting methodology estimates the risk of these substances with respect to genotoxicity, and will be added to those used for regulatory purposes in improving oral health and preventing oral carcinogenesis.

によって引用された
  1. Matsumoto Mariza, Filho Hugo Nary, Ferrari Raquel, Fernandes Kristianne, Renno Ana Claudia, Ribeiro Daniel, Genotoxicity of Endosseous Implants Using Two Cellular Lineages In Vitro, Journal of Oral Implantology, 40, 1, 2014. Crossref

  2. Botton G., Pires C. W., Cadoná F. C., Machado A. K., Azzolin V. F., Cruz I. B. M., Sagrillo M. R., Praetzel J. R., Toxicity of irrigating solutions and pharmacological associations used in pulpectomy of primary teeth, International Endodontic Journal, 49, 8, 2016. Crossref

  3. Hashem Mohamed I, Ahmad Zeeshan H, Binmgren Mohammed A, Anil Sukumaran, Huraib Sahar Bin, Assessment of DNA Damage in Leukoplakia Patients with Different Degrees of Dysplasia, The Journal of Contemporary Dental Practice, 16, 12, 2015. Crossref

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