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Critical Reviews™ in Oncogenesis

年間 4 号発行

ISSN 印刷: 0893-9675

ISSN オンライン: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Cell Fusion is a Potent Inducer of Aneuploidy and Drug Resistance in Tumor Cell/ Normal Cell Hybrids

巻 18, 発行 1-2, 2013, pp. 97-113
DOI: 10.1615/CritRevOncog.v18.i1-2.60
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要約

The biological phenomenon of cell fusion is involved in several physiological (fertilization, tissue regeneration) and pathophysiological (viral infection, cancer) processes. Particularly in the tumor context, cell fusion has been associated with a progression of this disease since hybrid cells derived from fusion events between tumor cells and normal cells, such as macrophages and adult stem cells, exhibited novel properties. These included an enhanced metastatogenic capacity, an increased proliferation, an increased resistance to undergo apoptosis or an increased drug resistance. But how the high phenotypic diversity of tumor hybrid cells is achieved? Cell fusion is a strong inducer of aneuploidy and genomic instability in tumor hybrid cells. Heterokaryon-to-synkaryon transition, representing the mechanism of nuclear fusion, is associated with a loss and re-sorting of chromosomes in a random manner, resulting in unique hybrid cells, whereby the degree of the aneuploidy/ genomic instability is further enhanced during ongoing rounds of cell divisions. The random nature of cell fusion tumor hybrid cells may originate already exhibiting an increased drug resistance, e.g., due to up-regulation of drug resistance related proteins. However, due to the aneuploidy/ genomic instability the hybrid cells may originate exhibiting an enhanced adaptation capacity, enabling these cells to withstand cellular stresses.

によって引用された
  1. Ghosh Srimoyee, Sternberg Paul W., Spatial and molecular cues for cell outgrowth during C. elegans uterine development, Developmental Biology, 396, 1, 2014. Crossref

  2. Xue Jianguo, Zhu Yuan, Sun Zixuan, Ji Runbi, Zhang Xu, Xu Wenrong, Yuan Xiao, Zhang Bin, Yan Yongmin, Yin Lei, Xu Huijuan, Zhang Leilei, Zhu Wei, Qian Hui, Tumorigenic hybrids between mesenchymal stem cells and gastric cancer cells enhanced cancer proliferation, migration and stemness, BMC Cancer, 15, 1, 2015. Crossref

  3. Zhou Xiaofeng, Merchak Kevin, Lee Woojin, Grande Joseph P., Cascalho Marilia, Platt Jeffrey L., Cell Fusion Connects Oncogenesis with Tumor Evolution, The American Journal of Pathology, 185, 7, 2015. Crossref

  4. Mohr Marieke, Zänker Kurt S., Dittmar Thomas, Cancer (stem) cell differentiation: An inherent or acquired property?, Medical Hypotheses, 85, 6, 2015. Crossref

  5. Coleman William B., Genomic Catastrophe and Neoplastic Transformation, The American Journal of Pathology, 185, 7, 2015. Crossref

  6. Platt Jeffrey, Zhou Xiaofeng, Lefferts Adam, Cascalho Marilia, Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy, International Journal of Molecular Sciences, 17, 7, 2016. Crossref

  7. Lazova Rossitza, LaBerge Greggory S., Duvall Eric, Spoelstra Nicole, Klump Vincent, Sznol Mario, Cooper Dennis, Spritz Richard A., Chang Joseph T., Pawelek John M., Mezey Eva, A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer, PLoS ONE, 8, 6, 2013. Crossref

  8. Noubissi Felicite, Ogle Brenda, Cancer Cell Fusion: Mechanisms Slowly Unravel, International Journal of Molecular Sciences, 17, 9, 2016. Crossref

  9. Dittmar Thomas, Zänker Kurt, Tissue Regeneration in the Chronically Inflamed Tumor Environment: Implications for Cell Fusion Driven Tumor Progression and Therapy Resistant Tumor Hybrid Cells, International Journal of Molecular Sciences, 16, 12, 2015. Crossref

  10. Strom Noah B., Bushley Kathryn E., Two genomes are better than one: history, genetics, and biotechnological applications of fungal heterokaryons, Fungal Biology and Biotechnology, 3, 1, 2016. Crossref

  11. Fried Sabrina, Tosun Songuel, Troost Gabriele, Keil Silvia, Zaenker Kurt S., Dittmar Thomas, Lai Hsin-Chih, Lipopolysaccharide (LPS) Promotes Apoptosis in Human Breast Epithelial × Breast Cancer Hybrids, but Not in Parental Cells, PLOS ONE, 11, 2, 2016. Crossref

  12. Tosun Songül, Fried Sabrina, Niggemann Bernd, Zänker Kurt, Dittmar Thomas, Hybrid Cells Derived from Human Breast Cancer Cells and Human Breast Epithelial Cells Exhibit Differential TLR4 and TLR9 Signaling, International Journal of Molecular Sciences, 17, 5, 2016. Crossref

  13. Goldenberg David M., Rooney Robert J., Loo Meiyu, Liu Donglin, Chang Chien-Hsing, Dittmar Thomas, In-Vivo Fusion of Human Cancer and Hamster Stromal Cells Permanently Transduces and Transcribes Human DNA, PLoS ONE, 9, 9, 2014. Crossref

  14. CHEN QIAN, WANG XIAOPING, WU HAO, WANG HUI, ZHU MINGAO, WANG ROUSHU, WU YING, ZHANG LUYAO, MENG QIAO, SONG RANRAN, ZHUANG ZHIXIANG, HUANG QIANG, Establishment of a dual-color fluorescence tracing orthotopic transplantation model of hepatocellular carcinoma, Molecular Medicine Reports, 13, 1, 2016. Crossref

  15. Berndt Benjamin, Haverkampf Sonja, Reith Georg, Keil Silvia, Niggemann Bernd, Zänker Kurt S., Dittmar Thomas, Komarova Yulia, Fusion of CCL21 Non-Migratory Active Breast Epithelial and Breast Cancer Cells Give Rise to CCL21 Migratory Active Tumor Hybrid Cell Lines, PLoS ONE, 8, 5, 2013. Crossref

  16. Miller William B., Torday John S., A systematic approach to cancer: evolution beyond selection, Clinical and Translational Medicine, 6, 1, 2017. Crossref

  17. Pham Lan V., Pogue Elizabeth, Ford Richard J., The Role of Macrophage/B-Cell Interactions in the Pathophysiology of B-Cell Lymphomas, Frontiers in Oncology, 8, 2018. Crossref

  18. Melzer Catharina, von der Ohe Juliane, Hass Ralf, Enhanced metastatic capacity of breast cancer cells after interaction and hybrid formation with mesenchymal stroma/stem cells (MSC), Cell Communication and Signaling, 16, 1, 2018. Crossref

  19. Noubissi Felicite K., Harkness Ty, Alexander Caroline M., Ogle Brenda M., Apoptosis‐induced cancer cell fusion: a mechanism of breast cancer metastasis, The FASEB Journal, 29, 9, 2015. Crossref

  20. Zhang Li-Na, Huang Ying-Hui, Zhao Lei, Fusion of macrophages promotes breast cancer cell proliferation, migration and invasion through activating epithelial-mesenchymal transition and Wnt/β-catenin signaling pathway, Archives of Biochemistry and Biophysics, 676, 2019. Crossref

  21. Melzer Catharina, von der Ohe Juliane, Hass Ralf, Involvement of Actin Cytoskeletal Components in Breast Cancer Cell Fusion with Human Mesenchymal Stroma/Stem-Like Cells, International Journal of Molecular Sciences, 20, 4, 2019. Crossref

  22. Parris George E., Cell-Cell Fusion, Chemotaxis and Metastasis, in Intercellular Communication in Cancer, 2015. Crossref

  23. Laberge Greggory, Duvall Eric, Haedicke Kay, Pawelek John, Leukocyte–Cancer Cell Fusion—Genesis of a Deadly Journey, Cells, 8, 2, 2019. Crossref

  24. Platt Jeffrey L., Cascalho Marilia, Cell Fusion in Malignancy: A Cause or Consequence? A Provocateur or Cure?, Cells, 8, 6, 2019. Crossref

  25. Chen , Liu , Huang , Li , Zhao , Feng , Zhao , Heat Stress-Induced Multiple Multipolar Divisions of Human Cancer Cells, Cells, 8, 8, 2019. Crossref

  26. Melzer Catharina, von der Ohe Juliane, Otterbein Hannah, Ungefroren Hendrik, Hass Ralf, Changes in uPA, PAI-1, and TGF-β Production during Breast Cancer Cell Interaction with Human Mesenchymal Stroma/Stem-Like Cells (MSC), International Journal of Molecular Sciences, 20, 11, 2019. Crossref

  27. Yang Fan, Shu Le, Zhang Xiaobo, Tumorigenesis and Metabolism Disorder, in Virus Infection and Tumorigenesis, 2019. Crossref

  28. Volk-Draper Lisa, Patel Radhika, Bhattarai Nihit, Yang Jie, Wilber Andrew, DeNardo David, Ran Sophia, Myeloid-Derived Lymphatic Endothelial Cell Progenitors Significantly Contribute to Lymphatic Metastasis in Clinical Breast Cancer, The American Journal of Pathology, 189, 11, 2019. Crossref

  29. Melzer Catharina, von der Ohe Juliane , Hass Ralf, In Vivo Cell Fusion between Mesenchymal Stroma/Stem-Like Cells and Breast Cancer Cells, Cancers, 11, 2, 2019. Crossref

  30. Manjunath Yariswamy, Porciani David, Mitchem Jonathan B., Suvilesh Kanve N., Avella Diego M., Kimchi Eric T., Staveley-O’Carroll Kevin F., Burke Donald H., Li Guangfu, Kaifi Jussuf T., Tumor-Cell–Macrophage Fusion Cells as Liquid Biomarkers and Tumor Enhancers in Cancer, International Journal of Molecular Sciences, 21, 5, 2020. Crossref

  31. Mirzayans Razmik, Murray David, Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence, International Journal of Molecular Sciences, 21, 4, 2020. Crossref

  32. Lartigue Lydia, Merle Candice, Lagarde Pauline, Delespaul Lucile, Lesluyes Tom, Le Guellec Sophie, Pérot Gaelle, Leroy Laura, Coindre Jean-Michel, Chibon Frédéric, Genome remodeling upon mesenchymal tumor cell fusion contributes to tumor progression and metastatic spread, Oncogene, 39, 21, 2020. Crossref

  33. Attia Noha, Mashal Mohamed, Mesenchymal Stem Cells: The Past Present and Future, in Cell Biology and Translational Medicine, Volume 11, 1312, 2020. Crossref

  34. Hass Ralf, von der Ohe Juliane, Ungefroren Hendrik, Impact of the Tumor Microenvironment on Tumor Heterogeneity and Consequences for Cancer Cell Plasticity and Stemness, Cancers, 12, 12, 2020. Crossref

  35. Melzer Catharina, Ohe Juliane von der, Hass Ralf, Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC, International Journal of Molecular Sciences, 21, 21, 2020. Crossref

  36. Zhang Li‐Na, Zhang Di‐Di, Yang Lei, Gu Yu‐Xuan, Zuo Qiu‐Ping, Wang Hao‐Yi, Xu Jia, Liu Dian‐Xin, Roles of cell fusion between mesenchymal stromal/stem cells and malignant cells in tumor growth and metastasis, The FEBS Journal, 288, 5, 2021. Crossref

  37. Baliu-Piqué Mariona, Pandiella Atanasio, Ocana Alberto, Breast Cancer Heterogeneity and Response to Novel Therapeutics, Cancers, 12, 11, 2020. Crossref

  38. Attia Noha, Mashal Mohamed, Puras Gustavo, Pedraz Jose Luis, Mesenchymal Stem Cells as a Gene Delivery Tool: Promise, Problems, and Prospects, Pharmaceutics, 13, 6, 2021. Crossref

  39. Merle Candice, Lagarde Pauline, Lartigue Lydia, Chibon Frédéric, Acquisition of cancer stem cell capacities after spontaneous cell fusion, BMC Cancer, 21, 1, 2021. Crossref

  40. Hass Ralf, von der Ohe Juliane, Dittmar Thomas, Cancer Cell Fusion and Post-Hybrid Selection Process (PHSP), Cancers, 13, 18, 2021. Crossref

  41. Tyagi Iram Shazia, Chen Si, Khan Muhammad Ajmal, Xie Jia, Li Ping Yin, Long Xi, Xue Hong, Intrinsic and chemically-induced daughter number variations in cancer cell lines, Cell Cycle, 20, 5-6, 2021. Crossref

  42. Zhang Jing, Qiao Qing, Xu Hong, Zhou Ru, Liu Xinzhe, Human cell polyploidization: The good and the evil, Seminars in Cancer Biology, 81, 2022. Crossref

  43. Sfera Adonis, Thomas Karina G., Sasannia Sarvin, Anton Jonathan J., Andronescu Christina V., Garcia Michael, Sfera Dan O., Cummings Michael A., Kozlakidis Zisis, Neuronal and Non-Neuronal GABA in COVID-19: Relevance for Psychiatry, Reports, 5, 2, 2022. Crossref

  44. Melzer Catharina, von der Ohe Juliane, Hass Ralf, In Vitro Fusion of Normal and Neoplastic Breast Epithelial Cells with Human Mesenchymal Stroma/Stem Cells Partially Involves Tumor Necrosis Factor Receptor Signaling, Stem Cells, 36, 7, 2018. Crossref

  45. Kloc Malgorzata, Subuddhi Arijita, Uosef Ahmed, Kubiak Jacek Z., Ghobrial Rafik M., Monocyte–Macrophage Lineage Cell Fusion, International Journal of Molecular Sciences, 23, 12, 2022. Crossref

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