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Critical Reviews™ in Biomedical Engineering

年間 6 号発行

ISSN 印刷: 0278-940X

ISSN オンライン: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

Improved Orthopaedic Bone Cement Formulations Based on Rubber Toughening

巻 28, 発行 3&4, 2000, pp. 457-461
DOI: 10.1615/CritRevBiomedEng.v28.i34.180
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要約

Poly(methylmethacrylate) (PMMA) bone cements have been used for the fixation of hip and knee implants since the early 1960s.' Aseptic loosening, related to fracture of the PMMA, continues to be the primary mode of failure for these prostheses. Failed prostheses must be replaced causing additional expense and patient trauma. Furthermore, the average lifetime of the revised prosthesis is significantly lower than that of a primary prosthesis.
Recent work by Moseley and co-workers led to the development of a promising new robber toughened cement. It is comprised of a matrix of the traditional PMMA with dispersed rubber particles to modify mechanical properties and, in particular, improve fracture toughness. The fracture toughness of the experimental material was 167% greater than the toughness of a nontoughened control; however, the elastic modulus and compressive strength were reduced. The reductions in properties should not pose a clinical problem based on results of the implant model reported by Moseley. More serious concerns were mixing and delivery problems and high residual monomer concentrations.
The formulation and chemical/mechanical characterization of new toughened acrylic formulations that have residual monomer levels equivalent to Simplex and better mixing properties are reported.

によって引用された
  1. Evans S L, Effects of porosity on the fatigue performance of polymethyl methacrylate bone cement: An analytical investigation, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 220, 1, 2006. Crossref

  2. Kotha Shiva, Li Chaodi, Schmid Steven, Mason James, Reinforcement of bone cement using zirconia fibers with and without acrylic coating, Journal of Biomedical Materials Research Part A, 88A, 4, 2009. Crossref

  3. Ayre Wayne Nishio, Birchall James C., Evans Samuel L., Denyer Stephen P., A novel liposomal drug delivery system for PMMA bone cements, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 104, 8, 2016. Crossref

  4. Arora Manit, Polymethylmethacrylate bone cements and additives: A review of the literature, World Journal of Orthopedics, 4, 2, 2013. Crossref

  5. Sa Yue, Yang Fang, Wang Yining, Wolke Joop G. C., Jansen John A., Modifications of Poly(Methyl Methacrylate) Cement for Application in Orthopedic Surgery, in Cutting-Edge Enabling Technologies for Regenerative Medicine, 1078, 2018. Crossref

  6. Puzhankara Lakshmi, Modified Bone Cement: A Reprieve for Horizontal Bone Defects, World Journal of Dentistry, 8, 5, 2017. Crossref

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