年間 6 号発行
ISSN 印刷: 0278-940X
ISSN オンライン: 1943-619X
Indexed in
Biology on a Chip: Microfabrication for Studying the Behavior of Cultured Cells
要約
The ability to culture cells in vitro has revolutionized hypothesis testing in basic cell and molecular biology research and has become a standard methodology in drug screening and toxicology assays. However, the traditional cell culture methodology−consisting essentially of the immersion of a large population of cells in a homogeneous fluid medium−has become increasingly limiting, both from a fundamental point of view (cells in vivo are surrounded by complex spatiotemporal microenvironments) and from a practical perspective (scaling up the number of fluid handling steps and cell manipulations for high-throughput studies in vitro is prohibitively expensive). Microfabrication technologies have enabled researchers to design, with micrometer control, the biochemical composition and topology of the substrate, the medium composition, as well as the type of neighboring cells surrounding the microenvironment of the cell. In addition, microtechnology is conceptually well suited for the development of fast, low-cost in vitro systems that allow for high-throughput culturing and analysis of cells under large numbers of conditions. Here we review a variety of applications of microfabrication in cell culture studies, with an emphasis on the biology of various cell types.
-
Wu Ze-Zhi, Kisaalita William S., Wang Lina, Zachman Angela L., Zhao Yiping, Hasneen Kowser, Machacek Dave, Stice Steven L., Effects of topography on the functional development of human neural progenitor cells, Biotechnology and Bioengineering, 106, 4, 2010. Crossref
-
Lin Zhang, Cherng-Wen Tan, Roy Partha, Trau Dieter, In-situ measurement of cellular microenvironments in a microfluidic device, Lab Chip, 9, 2, 2009. Crossref
-
Keenan Thomas M., Folch Albert, Biomolecular gradients in cell culture systems, Lab Chip, 8, 1, 2008. Crossref
-
Zhao Chuan, Witte Irene, Wittstock Gunther, Switching On Cell Adhesion with Microelectrodes, Angewandte Chemie International Edition, 45, 33, 2006. Crossref
-
Zhao Chuan, Witte Irene, Wittstock Gunther, Switching On Cell Adhesion with Microelectrodes, Angewandte Chemie, 118, 33, 2006. Crossref
-
Kaji Hirokazu, Sekine Soichiro, Hashimoto Masahiko, Kawashima Takeaki, Nishizawa Matsuhiko, Stepwise formation of patterned cell co-cultures in silicone tubing, Biotechnology and Bioengineering, 98, 4, 2007. Crossref
-
Frimat Jean-Philippe, Menne Heike, Michels Antje, Kittel Silke, Kettler Raffael, Borgmann Sabine, Franzke Joachim, West Jonathan, Plasma stencilling methods for cell patterning, Analytical and Bioanalytical Chemistry, 395, 3, 2009. Crossref
-
Spegel Christer, Heiskanen Arto, Skjolding Lars Henrik Dæhli, Emnéus Jenny, Chip Based Electroanalytical Systems for Cell Analysis, Electroanalysis, 20, 6, 2008. Crossref
-
Bassik Noy, Stern George M., Jamal Mustapha, Gracias David H., Patterning Thin Film Mechanical Properties to Drive Assembly of Complex 3D Structures, Advanced Materials, 20, 24, 2008. Crossref
-
Groisman Alex, Lobo Caroline, Cho HoJung, Campbell J Kyle, Dufour Yann S, Stevens Ann M, Levchenko Andre, A microfluidic chemostat for experiments with bacterial and yeast cells, Nature Methods, 2, 9, 2005. Crossref
-
Where are the biologists? : A series of mini-reviews covering new trends in fundamental and applied research, and potential applications of miniaturised technologies, Lab on a Chip, 6, 4, 2006. Crossref
-
Lee Kwang Ho, Kwon Gu Han, Shin Su Jung, Baek Ju-Yeoul, Han Dong Keun, Park Yongdoo, Lee Sang Hoon, Hydrophilic electrospun polyurethane nanofiber matrices for hMSC culture in a microfluidic cell chip, Journal of Biomedical Materials Research Part A, 90A, 2, 2009. Crossref
-
Tamanaha Cy R., Malito Michael P., Mulvaney Shawn P., Whitman Lloyd J., Reusable, compression-sealed fluid cells for surface mounting to planar substrates, Lab on a Chip, 9, 10, 2009. Crossref
-
Becker Holger, Gärtner Claudia, Polymer microfabrication technologies for microfluidic systems, Analytical and Bioanalytical Chemistry, 390, 1, 2008. Crossref
-
Santillo Michael F., Arcibal Imee G., Ewing Andrew G., Flow characterization of a microfluidic device to selectively and reliably apply reagents to a cellular network, Lab on a Chip, 7, 9, 2007. Crossref
-
Tan Wei, Desai Tejal A., Microscale multilayer cocultures for biomimetic blood vessels, Journal of Biomedical Materials Research Part A, 72A, 2, 2005. Crossref
-
Betancourt Tania, Brannon-Peppas Lisa, Micro- and nanofabrication methods in nanotechnological medical and pharmaceutical devices, International Journal of Nanomedicine, 1, 4, 2006. Crossref
-
Tourovskaia Anna, Figueroa-Masot Xavier, Folch Albert, Long-term microfluidic cultures of myotube microarrays for high-throughput focal stimulation, Nature Protocols, 1, 3, 2006. Crossref
-
Wright Dylan, Rajalingam Bimalraj, Selvarasah Selvapraba, Dokmeci Mehmet R., Khademhosseini Ali, Generation of static and dynamic patterned co-cultures using microfabricated parylene-C stencils, Lab on a Chip, 7, 10, 2007. Crossref
-
Lee Philip J., Gaige Terry A., Ghorashian Navid, Hung Paul J., Microfluidic Tissue Model for Live Cell Screening, Biotechnology Progress, 23, 4, 2007. Crossref
-
GAO Kan, LIU Bing-Fang, XU Qun-Yuan, A Morphologic Study on Creation of Neural Network of Cultured Striatal Neurons in vitro Using Soft Lithography Techniques*, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2009, 6, 2009. Crossref
-
Wu Huei-Ing, Cheng Gia-Her, Wong Yi-Yun, Lin Chia-Min, Fang Weileun, Chow Wei-Yuan, Chang Yen-Chung, A lab-on-a-chip platform for studying the subcellular functional proteome of neuronal axons, Lab Chip, 10, 5, 2010. Crossref
-
Vickerman Vernella, Blundo Jennifer, Chung Seok, Kamm Roger, Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging, Lab on a Chip, 8, 9, 2008. Crossref
-
Ionov Leonid, Synytska Alla, Diez Stefan, Temperature-Induced Size-Control of Bioactive Surface Patterns, Advanced Functional Materials, 18, 10, 2008. Crossref
-
Domachuk Peter, Tsioris Konstantinos, Omenetto Fiorenzo G., Kaplan David L., Bio-microfluidics: Biomaterials and Biomimetic Designs, Advanced Materials, 22, 2, 2010. Crossref
-
Villa Max, Pope Sara, Conover Joanne, Fan Tai-Hsi, Growth of primary embryo cells in a microculture system, Biomedical Microdevices, 12, 2, 2010. Crossref
-
Park Jungyul, Kim Il Chaek, Baek Jeongeun, Cha Misun, Kim Jinseok, Park Sukho, Lee Junghoon, Kim Byungkyu, Micro pumping with cardiomyocyte–polymer hybrid, Lab on a Chip, 7, 10, 2007. Crossref
-
Kawashima Takeaki, Yokoi Takeshi, Kaji Hirokazu, Nishizawa Matsuhiko, Transfer of two-dimensional patterns of human umbilical vein endothelial cells into fibrin gels to facilitate vessel formation, Chemical Communications, 46, 12, 2010. Crossref
-
Yamazoe Hironori, Tanabe Toshizumi, Cell micropatterning on an albumin-based substrate using an inkjet printing technique, Journal of Biomedical Materials Research Part A, 91A, 4, 2009. Crossref
-
Kim Deok-Ho, Lee Hyojin, Lee Young Kwang, Nam Jwa-Min, Levchenko Andre, Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells, Advanced Materials, 22, 41, 2010. Crossref
-
Pearce Thomas M., Williams Justin C., Microtechnology: Meet neurobiology, Lab Chip, 7, 1, 2007. Crossref
-
Wada Ken-Ichi, Taniguchi Akiyoshi, Kobayashi Jun, Yamato Masayuki, Okano Teruo, Live cells-based cytotoxic sensorchip fabricated in a microfluidic system, Biotechnology and Bioengineering, 99, 6, 2008. Crossref
-
Qin Dong, Xia Younan, Whitesides George M, Soft lithography for micro- and nanoscale patterning, Nature Protocols, 5, 3, 2010. Crossref
-
Lovchik Robert D., Tonna Noemi, Bianco Fabio, Matteoli Michela, Delamarche Emmanuel, A microfluidic device for depositing and addressing two cell populations with intercellular population communication capability, Biomedical Microdevices, 12, 2, 2010. Crossref
-
Xing Shige, Liu Wenwen, Huang Zhuo, Chen Long, Sun Kang, Han Dong, Zhang Wei, Jiang Xingyu, Development of neurons on micropatterns reveals that growth cone responds to a sharp change of concentration of laminin, ELECTROPHORESIS, 31, 18, 2010. Crossref
-
Wang Lin, Sun Bing, Ziemer Katherine S., Barabino Gilda A., Carrier Rebecca L., Chemical and physical modifications to poly(dimethylsiloxane) surfaces affect adhesion of Caco-2 cells, Journal of Biomedical Materials Research Part A, 9999A, 2009. Crossref
-
Jinno Satoshi, Moeller Hannes-Christian, Chen Chia-Ling, Rajalingam Bimal, Chung Bong Geun, Dokmeci Mehmet R., Khademhosseini Ali, Microfabricated multilayer parylene-C stencils for the generation of patterned dynamic co-cultures, Journal of Biomedical Materials Research Part A, 86A, 1, 2008. Crossref
-
van Meerbergen Bart, Raemaekers Tim, Winters Kurt, Braeken Dries, Bartic Carmen, Spira Micha, Engelborghs Yves, Annaert Wim G., Borghs Gustaaf, Improving neuronal adhesion on chip using a phagocytosis-like event, Journal of Experimental Nanoscience, 2, 1-2, 2007. Crossref
-
Grayson Warren L., Martens Timothy P., Eng George M., Radisic Milica, Vunjak-Novakovic Gordana, Biomimetic approach to tissue engineering, Seminars in Cell & Developmental Biology, 20, 6, 2009. Crossref
-
Wu Ze-Zhi, Zhao Yiping, Kisaalita William S., Interfacing SH-SY5Y human neuroblastoma cells with SU-8 microstructures, Colloids and Surfaces B: Biointerfaces, 52, 1, 2006. Crossref
-
Liu Bingfang, Ma Jun, Gao Erjing, He Yu, Cui Fuzhai, Xu Qunyuan, Development of an artificial neuronal network with post-mitotic rat fetal hippocampal cells by polyethylenimine, Biosensors and Bioelectronics, 23, 8, 2008. Crossref
-
Tagaya Motohiro, Yamazaki Tomohiko, Tsuya Daiji, Sugimoto Yoshimasa, Hanagata Nobutaka, Ikoma Toshiyuki, Nano/Microstructural Effect of Hydroxyapatite Nanocrystals on Hepatocyte Cell Aggregation and Adhesion, Macromolecular Bioscience, 2011. Crossref
-
Li Nianzhen, Folch Albert, Integration of topographical and biochemical cues by axons during growth on microfabricated 3-D substrates, Experimental Cell Research, 311, 2, 2005. Crossref
-
Liu B.F., Ma J., Xu Q.Y., Cui F.Z., Regulation of charged groups and laminin patterns for selective neuronal adhesion, Colloids and Surfaces B: Biointerfaces, 53, 2, 2006. Crossref
-
Jamal Mustapha, Bassik Noy, Cho Jeong-Hyun, Randall Christina L., Gracias David H., Directed growth of fibroblasts into three dimensional micropatterned geometries via self-assembling scaffolds, Biomaterials, 31, 7, 2010. Crossref
-
Puleo Christopher M., Yeh Hsin-Chih, Wang Tza-Huei, Applications of MEMS Technologies in Tissue Engineering, Tissue Engineering, 13, 12, 2007. Crossref
-
Banerjee Pratik, Bhunia Arun K., Mammalian cell-based biosensors for pathogens and toxins, Trends in Biotechnology, 27, 3, 2009. Crossref
-
Taniguchi Akiyoshi, Live cell-based sensor cells, Biomaterials, 31, 23, 2010. Crossref
-
LUO Yali, GAO Kan, XU Qunyuan, A Morphological Study on Creation of Neural Flow Patterns with Cultured Striatal Neurons <I>in Vitro</I> Using A Microfluidic Technique, ACTA BIOPHYSICA SINICA, 27, 2, 2011. Crossref
-
Macis Elisabetta, Tedesco Mariateresa, Massobrio Paolo, Raiteri Roberto, Martinoia Sergio, An automated microdrop delivery system for neuronal network patterning on microelectrode arrays, Journal of Neuroscience Methods, 161, 1, 2007. Crossref
-
Norman James J., Collins John M., Sharma Sadhana, Russell Brenda, Desai Tejal A., Microstructures in 3D Biological Gels Affect Cell Proliferation, Tissue Engineering, 2007. Crossref
-
Rajagopalan Jagannathan, Saif M Taher A, MEMS sensors and microsystems for cell mechanobiology, Journal of Micromechanics and Microengineering, 21, 5, 2011. Crossref
-
Shimada Y, Suzuki M, Sugiyama M, Kumagai I, Umetsu M, Bioassisted capture and release of nanoparticles on nanolithographed ZnO films, Nanotechnology, 22, 27, 2011. Crossref
-
Gross Pamela G., Kartalov Emil P., Microfluidics For Nanoneuroscience, in Microfluidic Devices in Nanotechnology, 2010. Crossref
-
Seger R R, Rabus D G, Ichihashi Y, Bruendel M, Isaacson M S, Evanescent-Field Excitation of Fluophores in Cultured Neural Networks by Integrated Polymer Waveguides, IEEE Journal of Selected Topics in Quantum Electronics, 16, 4, 2010. Crossref
-
Yucel Deniz, Kose Gamze Torun, Hasirci Vasif, Polyester based nerve guidance conduit design, Biomaterials, 31, 7, 2010. Crossref
-
Kothapalli Chandrasekhar R., van Veen Ed, de Valence Sarra, Chung Seok, Zervantonakis Ioannis K., Gertler Frank B., Kamm Roger D., A high-throughput microfluidic assay to study neurite response to growth factor gradients, Lab Chip, 11, 3, 2011. Crossref
-
Kaji Hirokazu, Camci-Unal Gulden, Langer Robert, Khademhosseini Ali, Engineering systems for the generation of patterned co-cultures for controlling cell–cell interactions, Biochimica et Biophysica Acta (BBA) - General Subjects, 1810, 3, 2011. Crossref
-
Prasad Shalini, Quijano Jorge, Development of nanostructured biomedical micro-drug testing device based on in situ cellular activity monitoring, Biosensors and Bioelectronics, 21, 7, 2006. Crossref
-
Zeng Huan-Chang, Ho Yi-Cheng, Chen Shih-Ta, Wu Huei-In, Tung Hsi-Wen, Fang Wei-Leun, Chang Yen-Chung, Studying the formation of large cell aggregates in patterned neuronal cultures, Journal of Neuroscience Methods, 165, 1, 2007. Crossref
-
Wang Wenjie, Itaka Keiji, Ohba Shinsuke, Nishiyama Nobuhiro, Chung Ung-il, Yamasaki Yuichi, Kataoka Kazunori, 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells, Biomaterials, 30, 14, 2009. Crossref
-
Norman James J., Collins John M., Sharma Sadhana, Russell Brenda, Desai Tejal A., Microstructures in 3D Biological Gels Affect Cell Proliferation, Tissue Engineering Part A, 14, 3, 2008. Crossref
-
Panchawagh Hrishikesh V., Faheem Faheem F., Herrmann Cari F., Serrell David B., Finch Dudley S., Mahajan Roop L., A flip–chip encapsulation method for packaging of MEMS actuators using surface micromachined polysilicon caps for BioMEMS applications, Sensors and Actuators A: Physical, 134, 1, 2007. Crossref
-
Şen Mustafa, Ino Kosuke, Shiku Hitoshi, Matsue Tomokazu, Accumulation and detection of secreted proteins from single cells for reporter gene assays using a local redox cycling-based electrochemical (LRC-EC) chip device, Lab on a Chip, 12, 21, 2012. Crossref
-
Seidi Azadeh, Ramalingam Murugan, Cell Patterning Technologies for Tissue Engineering, in Biomedical Materials and Diagnostic Devices, 2012. Crossref
-
Gorelick Sergey, Rahkila Paavo, Sagari A.R. A., Sajavaara Timo, Cheng Sulin, Karlsson Lennart B., van Kan Jeroen A., Whitlow Harry J., Growth of osteoblasts on lithographically modified surfaces, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 260, 1, 2007. Crossref
-
Lantada Andres Díaz, Endrino José Luis, Vaquero Vanessa Sánchez, Mosquera Adolfo, Lafont Pilar, García-Ruiz Josefa Predestinación, Tissue Engineering Using Novel Rapid Prototyped Diamond-Like Carbon Coated Scaffolds, Plasma Processes and Polymers, 9, 1, 2012. Crossref
-
Hsiao Cheston, Palecek Sean P., Microwell Regulation of Pluripotent Stem Cell Self-Renewal and Differentiation, BioNanoScience, 2, 4, 2012. Crossref
-
Yoon Hwa In, Choi Ji Suk, Lee Byung Kook, Oh Je Hoon, Cho Yong Woo, Arbitrary, complex cell patterning via inkjet printing of a cell membrane-anchoring polymer, Macromolecular Research, 20, 5, 2012. Crossref
-
Kim Deok-Ho, Provenzano Paolo P., Smith Chris L., Levchenko Andre, Matrix nanotopography as a regulator of cell function, Journal of Cell Biology, 197, 3, 2012. Crossref
-
Norman James J, Mukundan Vikram, Bernstein Daniel, Pruitt Beth L, Microsystems for Biomechanical Measurements, Pediatric Research, 63, 5, 2008. Crossref
-
Delaittre Guillaume, Greiner Alexandra M., Pauloehrl Thomas, Bastmeyer Martin, Barner-Kowollik Christopher, Chemical approaches to synthetic polymer surface biofunctionalization for targeted cell adhesion using small binding motifs, Soft Matter, 8, 28, 2012. Crossref
-
Primiceri Elisabetta, Chiriacò Maria Serena, Rinaldi Ross, Maruccio Giuseppe, Cell chips as new tools for cell biology – results, perspectives and opportunities, Lab on a Chip, 13, 19, 2013. Crossref
-
High Throughput Screening and Microarray Analysis, in Principles of Toxicology Testing, 2007. Crossref
-
Tang-Schomer Min D., Davies Paul, Graziano Daniel, Thurber Amy E., Kaplan David L., Neural circuits with long-distance axon tracts for determining functional connectivity, Journal of Neuroscience Methods, 222, 2014. Crossref
-
Cell culture methodology, in Principles of Toxicology Testing, 2013. Crossref
-
Kelc Robi, Trapecar Martin, Vogrin Matjaz, Cencic Avrelija, Skeletal muscle-derived cell cultures as potent models in regenerative medicine research, Muscle & Nerve, 47, 4, 2013. Crossref
-
Tang-Schomer Min D., Davies Paul, Graziano Daniel, Thurber Amy E., Kaplan David L., WITHDRAWN: Neural circuits with long-distance axon tracts for determining functional connectivity, Journal of Neuroscience Methods, 2013. Crossref
-
Jones Meghan C., Kobie James J., DeLouise Lisa A., Characterization of cell seeding and specific capture of B cells in microbubble well arrays, Biomedical Microdevices, 15, 3, 2013. Crossref
-
Kwiat Moria, Stein Daniel, Patolsky Fernando, Nanotechnology meets electrophysiology, Current Opinion in Biotechnology, 24, 4, 2013. Crossref
-
Alrifaiy Ahmed, Lindahl Olof A., Ramser Kerstin, Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering, Polymers, 4, 3, 2012. Crossref
-
Gammoudi I., Raimbault V., Tarbague H., Moroté F., Grauby-Heywang C., Othmane A., Kalfat R., Moynet D., Rebière D., Dejous C., Cohen-Bouhacina T., Enhanced bio-inspired microsensor based on microfluidic/bacteria/love wave hybrid structure for continuous control of heavy metals toxicity in liquid medium, Sensors and Actuators B: Chemical, 198, 2014. Crossref
-
Chen Liao , Shiyan Hu , Physical-Level Synthesis for Digital Lab-On-a-Chip Considering Variation, Contamination, and Defect, IEEE Transactions on NanoBioscience, 13, 1, 2014. Crossref
-
Christen J.B., Andreou A.G., Hybrid Silicon/Silicone (polydimethylsiloxane) Microsystem for Cell Culture, 2006 IEEE International Symposium on Circuits and Systems, 2006. Crossref
-
Nishizawa M., Kaji H., Tsukidate K., Hashimoto M., Abe T., Elcrochemical bio-lithography for in-situ immobilization of proteins and cells within microchannels, The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05., 1, 2005. Crossref
-
Sorkio Anni E., Vuorimaa-Laukkanen Elina P., Hakola Hanna M., Liang Huamin, Ujula Tiina A., Valle-Delgado Juan José, Österberg Monika, Yliperttula Marjo L., Skottman Heli, Biomimetic collagen I and IV double layer Langmuir–Schaefer films as microenvironment for human pluripotent stem cell derived retinal pigment epithelial cells, Biomaterials, 51, 2015. Crossref
-
Nishizawa M., Kaji H., Electrochemical Bio-Lithography for In Situ Control of Cellular Adhesion and Growth on a Chip, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, 2005. Crossref
-
Ornoff Douglas M., Wang Yuli, Proctor Angela, Shah Akash S., Allbritton Nancy L., Co-fabrication of chitosan and epoxy photoresist to form microwell arrays with permeable hydrogel bottoms, Biomaterials, 74, 2016. Crossref
-
Obien Marie Engelene J., Deligkaris Kosmas, Bullmann Torsten, Bakkum Douglas J., Frey Urs, Revealing neuronal function through microelectrode array recordings, Frontiers in Neuroscience, 8, 2015. Crossref
-
Saeed Omer Osman, Li Rui, Deng Yulin, Microfluidic Approaches for Cancer Cell Separation: Review, Journal of Biomedical Science and Engineering, 07, 12, 2014. Crossref
-
Blain Christen Jennifer M., Andreou Andreas G., Integrated PDMS/CMOS Microsystem for Autonomous Incubation and Imaging in Cell Culture Studies, 2006 IEEE/NLM Life Science Systems and Applications Workshop, 2006. Crossref
-
Kaji Hirokazu, Biofabrication techniques for biologically relevant tissue models and drug delivery devices, 2012 International Symposium on Micro-NanoMechatronics and Human Science (MHS), 2012. Crossref
-
Christen Jennifer Blain, Andreou Andreas G., Hybrid Silicon/Silicone (polydimethylsiloxane) Microsystem for Cell Culture, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society, 2006. Crossref
-
Nishizawa Matsuhiko, Abe Takashi, Kaji Hirokazu, Electrochemical Approach to Pattern Cells within Three-Dimensional Microstructures, 2006 IEEE International Symposium on MicroNanoMechanical and Human Science, 2006. Crossref
-
Willaert Ronnie, Goossens Katty, Microfluidic Bioreactors for Cellular Microarrays, Fermentation, 1, 1, 2015. Crossref
-
Regmi Shobha, Jeong Jee-Heon, Superiority of three-dimensional stem cell clusters over monolayer culture: An archetype to biological application, Macromolecular Research, 24, 12, 2016. Crossref
-
Cheng Jonathan W., Chang Tim C., Bhattacharjee Nirveek, Folch Albert, An open-chamber flow-focusing device for focal stimulation of micropatterned cells, Biomicrofluidics, 10, 2, 2016. Crossref
-
Hao Rui, Wei Yuanchen, Li Chaobo, Chen Feng, Chen Deyong, Zhao Xiaoting, Luan Shaoliang, Fan Beiyuan, Guo Wei, Wang Junbo, Chen Jian, A Microfabricated 96-Well 3D Assay Enabling High-Throughput Quantification of Cellular Invasion Capabilities, Scientific Reports, 7, 1, 2017. Crossref
-
López-Saucedo Felipe, Flores-Rojas Guadalupe G., Meléndez-Ortiz H. Iván, Morfín-Gutierrez Adriana, Luna-Straffon Marco A., Bucio Emilio, Stimuli-Responsive Nanomaterials for Drug Delivery, in Characterization and Biology of Nanomaterials for Drug Delivery, 2019. Crossref
-
Li Jingchen, Jiang Hongyuan, Regulating positioning and orientation of mitotic spindles via cell size and shape, Physical Review E, 97, 1, 2018. Crossref
-
Majid Ebrahimi Warkiani, Lim Chwee Teck, Microfluidic Platforms for Human Disease Cell Mechanics Studies, in Materiomics: Multiscale Mechanics of Biological Materials and Structures, 546, 2013. Crossref
-
Haque M. Amanul, Saif Taher, Mechanical Testing at the Micro/Nanoscale, in Springer Handbook of Experimental Solid Mechanics, 2008. Crossref
-
Munisamy S., Vaidyanathan T. K., Vaidyanathan J., A Bone-Like Precoating Strategy for Implants: Collagen Immobilization and Its Mineralization on Pure Titanium Implant Surface, Journal of Oral Implantology, 34, 2, 2008. Crossref
-
Wen Yuan, Zhang Xudong, Yang Shang-Tian, Medium to High Throughput Screening: Microfabrication and Chip-Based Technology, in New Technologies for Toxicity Testing, 745, 2012. Crossref
-
Benderskaya Elena N., Nonlinear Trends in Modern Artificial Intelligence: A New Perspective, in Beyond Artificial Intelligence, 4, 2013. Crossref
-
Banerjee Pratik, Franz Briana, Bhunia Arun K., Mammalian Cell-Based Sensor System, in Whole Cell Sensing Systems I, 2010. Crossref
-
Wolf Marc, Zimmermann Martin, Delamarche Emmanuel, Hunziker Patrick, Screening cell surface receptors using micromosaic immunoassays, Biomedical Microdevices, 9, 2, 2007. Crossref
-
Deng Bing, Wang Heyi, Tan Zhaoyi, Quan Yi, Microfluidic Cell Trapping for Single-Cell Analysis, Micromachines, 10, 6, 2019. Crossref
-
Obien Marie Engelene J., Frey Urs, Large-Scale, High-Resolution Microelectrode Arrays for Interrogation of Neurons and Networks, in In Vitro Neuronal Networks, 22, 2019. Crossref
-
Cheng Chao-Min, Kuan Chen-Meng, Chen Chien-Fu, Polymeric-Based In Vitro Diagnostic Devices, in In-Vitro Diagnostic Devices, 2016. Crossref
-
Shahidian Azadeh, Ghassemi Majid, Mohammadi Javad, Hashemi Mohadeseh, Application of microfluidics in cancer treatment, in Bio-Engineering Approaches to Cancer Diagnosis and Treatment, 2020. Crossref
-
Liao Yumin, Yu Ningmei, Tian Dian, Wang Chen, Li Shuaijun, Li Zhengpeng, An Intelligent Low-Power Low-Cost Mobile Lab-On-Chip Yeast Cell Culture Platform, IEEE Access, 8, 2020. Crossref
-
Chen Xiaodao, Wang Yuewei, Wan Chaowei, Huang Xiaohui, Fault Tolerance-Aware Design Technique for Cyber-Physical Digital Microfluidic Biochips, in Big Data Analytics for Cyber-Physical Systems, 2020. Crossref
-
Vazquez Maribel, Microfluidic and Microscale Assays to Examine Regenerative Strategies in the Neuro Retina, Micromachines, 11, 12, 2020. Crossref
-
Tomás Ruben M. F., Gibson Matthew I., 100th Anniversary of Macromolecular Science Viewpoint: Re-Engineering Cellular Interfaces with Synthetic Macromolecules Using Metabolic Glycan Labeling, ACS Macro Letters, 9, 7, 2020. Crossref
-
Abdalkader Rodi, Konishi Satoshi, Fujita Takuya, The Development of Biomimetic Aligned Skeletal Muscles in a Fully 3D Printed Microfluidic Device, Biomimetics, 7, 1, 2021. Crossref
-
Venter Henrietta, Aroonnual Amornrat, Janvilisri Tavan, Ounjai Puey, Chankhamhaengdecha Surang, Microfluidics: innovative approaches for rapid diagnosis of antibiotic-resistant bacteria, Essays in Biochemistry, 61, 1, 2017. Crossref
-
Zhao Chuan, Zawisza Izabella, Nullmeier Martina, Burchardt Malte, Träuble Markus, Witte Irene, Wittstock Gunther, Microelectrochemical Modulation of Micropatterned Cellular Environments, Langmuir, 24, 14, 2008. Crossref
-
Dai Jing, Yoon Sung Ho, Sim Hye Young, Yang Yoon Sun, Oh Tae Kwang, Kim Jihyun F., Hong Jong Wook, Charting Microbial Phenotypes in Multiplex Nanoliter Batch Bioreactors, Analytical Chemistry, 85, 12, 2013. Crossref
-
Ashammakhi Nureddin, Hernandez Ana Lopez, Unluturk Bige Deniz, Quintero Sergio A., Barros Natan Roberto, Hoque Apu Ehsanul, Bin Shams Abdullah, Ostrovidov Serge, Li Jinxing, Contag Christopher, Gomes Antoinette S., Holgado Miguel, Biodegradable Implantable Sensors: Materials Design, Fabrication, and Applications, Advanced Functional Materials, 31, 49, 2021. Crossref
-
Feller Karl-Heinz, Mammalian Cell-Based Biosensors, in Handbook of Cell Biosensors, 2021. Crossref
-
Yadav Shital, Majumder Abhijit, Biomimicked hierarchical 2D and 3D structures from natural templates: applications in cell biology, Biomedical Materials, 16, 6, 2021. Crossref
-
Morgan Nicole Y., Microfabricated Devices for Confocal Microscopy on Biological Samples, in Confocal Microscopy, 2304, 2021. Crossref
-
Reuther Cordula, Tucker Robert, Ionov Leonid, Diez Stefan, Programmable Patterning of Protein Bioactivity by Visible Light, Nano Letters, 14, 7, 2014. Crossref
-
Feller Karl-Heinz, Mammalian Cell-Based Biosensors, in Handbook of Cell Biosensors, 2022. Crossref
-
Wanamaker Carolyn L., Neff Brittany S., Nejati-Namin Azieta, Spatenka Erin R., Yang Mong-Lin, Effect of Chemical and Physical Modifications on the Wettability of Polydimethylsiloxane Surfaces, Journal of Chemical Education, 96, 6, 2019. Crossref
-
Kumar Avinash, Panda Udwesh, Microfluidics-based devices and their role on point-of-care testing, in Biosensor Based Advanced Cancer Diagnostics, 2022. Crossref
-
Jans K., Van Meerbergen B., Reekmans G., Bonroy K., Annaert W., Maes G., Engelborghs Y., Borghs G., Bartic C., Chemical and Biological Characterization of Thiol SAMs for Neuronal Cell Attachment, Langmuir, 25, 8, 2009. Crossref
-
Baek Dahee, Lee Sang Hun, Jun Bong-Hyun, Lee Seung Hwan, Lithography Technology for Micro- and Nanofabrication, in Nanotechnology for Bioapplications, 1309, 2021. Crossref
-
Lee Philip J., Ghorashian Navid, Gaige Terry A., Hung Paul J., Microfluidic System for Automated Cell-Based Assays, JALA: Journal of the Association for Laboratory Automation, 12, 6, 2007. Crossref
-
Dubiel Evan A., Martin Yves, Vermette Patrick, Bridging the Gap Between Physicochemistry and Interpretation Prevalent in Cell−Surface Interactions, Chemical Reviews, 111, 4, 2011. Crossref
-
Kwiat Moria, Elnathan Roey, Pevzner Alexander, Peretz Asher, Barak Boaz, Peretz Hagit, Ducobni Tamir, Stein Daniel, Mittelman Leonid, Ashery Uri, Patolsky Fernando, Highly Ordered Large-Scale Neuronal Networks of Individual Cells – Toward Single Cell to 3D Nanowire Intracellular Interfaces, ACS Applied Materials & Interfaces, 4, 7, 2012. Crossref
-
Cheng Jonathan W., Sip Christopher G., Lindstedt Philip R., Boitano Ross, Bluestein Blake M., Gamble Lara J., Folch Albert, “Chip-on-a-Transwell” Devices for User-Friendly Control of the Microenvironment of Cultured Cells, ACS Applied Bio Materials, 2, 11, 2019. Crossref
-
Yamazoe Hironori, Nakanishi Hisashi, Kashiwagi Yukiyasu, Nakamoto Masami, Tachibana Akira, Hagihara Yoshihisa, Tanabe Toshizumi, Changes in Cell Adhesiveness and Physicochemical Properties of Cross-Linked Albumin Films after Ultraviolet Irradiation, Langmuir, 32, 1, 2016. Crossref
-
Zhao Chuan, Burchardt Malte, Brinkhoff Thorsten, Beardsley Christine, Simon Meinhard, Wittstock Gunther, Microfabrication of Patterns of Adherent Marine Bacterium Phaeobacter inhibens Using Soft Lithography and Scanning Probe Lithography, Langmuir, 26, 11, 2010. Crossref
-
Salim Amani, Ding Zhenwen, Ziaie Babak, Micromachined Hydrogel Stamper for Soft Printing of Biomolecules with Adjustable Feature Dimensions, Analytical Chemistry, 81, 11, 2009. Crossref
-
Feller Karl-Heinz, Mammalian Cell-Based Biosensors, in Handbook of Cell Biosensors, 2021. Crossref
-
Liu Xixia, Lu Xingchen, Wang Zonghuan, Yang Xiaohui, Dai Guangli, Yin Jun, Huang Yong, Effect of bore fluid composition on poly(lactic-co-glycolic acid) hollow fiber membranes fabricated by dry-jet wet spinning, Journal of Membrane Science, 640, 2021. Crossref
-
Nagahara Yukitoshi, Sekine Hiroaki, Otaki Mari, Hayashi Masakazu, Murase Norio, Use of high concentrations of dimethyl sulfoxide for cryopreservation of HepG2 cells adhered to glass and polydimethylsiloxane matrices, Cryobiology, 72, 1, 2016. Crossref
-
Kaji Hirokazu, Ishibashi Takeshi, Nagamine Kuniaki, Kanzaki Makoto, Nishizawa Matsuhiko, Electrically induced contraction of C2C12 myotubes cultured on a porous membrane-based substrate with muscle tissue-like stiffness, Biomaterials, 31, 27, 2010. Crossref
-
Torisawa Yu-suke, Takagi Airi, Nashimoto Yuji, Yasukawa Tomoyuki, Shiku Hitoshi, Matsue Tomokazu, A multicellular spheroid array to realize spheroid formation, culture, and viability assay on a chip, Biomaterials, 28, 3, 2007. Crossref
-
Castillo Ransanz Lucía, Van Altena Pieter F. J., Heine Vivi M., Accardo Angelo, Engineered cell culture microenvironments for mechanobiology studies of brain neural cells, Frontiers in Bioengineering and Biotechnology, 10, 2022. Crossref