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Critical Reviews™ in Eukaryotic Gene Expression

年間 6 号発行

ISSN 印刷: 1045-4403

ISSN オンライン: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Polymeric Gene Carriers

巻 15, 発行 4, 2005, pp. 317-342
DOI: 10.1615/CritRevEukarGeneExpr.v15.i4.30
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要約

Polymeric gene carriers are a potential alternative to using viral vectors. Polymeric carriers have relatively low immunogenicity and cytotoxicity. In addition, polymeric carriers can accommodate large-size DNA, be conjugated with appropriate functionalities, and be administered repeatedly. In spite of these advantages, polymeric gene carriers have some limitations, such as low gene transfection efficiencies and relatively short duration of gene expression. Therefore, extensive research has been conducted toward the development of efficient polymeric carriers. In this review, we discuss current problems associated with polymeric gene carriers and various strategies against transfection barriers—in particular, gene stabilization and protection, cellular targeting, endosomal escaping, nuclear targeting, unpackaging, and biocompatibility. Finally, requirements for future polymeric gene carriers are considered. With all these ongoing efforts, polymeric carriers have become one of the promising gene delivery methods for human gene therapy.

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  1. Kang Han Chang, Bae You Han, Transfection of Rat Pancreatic Islet Tissue by Polymeric Gene Vectors, Diabetes Technology & Therapeutics, 11, 7, 2009. Crossref

  2. Aydin Zeynep, Akbas Fahri, Senel Mehmet, Koc S. Naci, Evaluation of Jeffamine®-cored PAMAM dendrimers as an efficientin vitrogene delivery system, Journal of Biomedical Materials Research Part A, 100A, 10, 2012. Crossref

  3. Ryu Dong-Wook, Kim Hyun Ah, Kim Soonhag, Lee Minhyung, VEGF receptor binding peptide-linked amphiphilic peptide with arginines and valines for endothelial cell-specific gene delivery, Journal of Drug Targeting, 20, 7, 2012. Crossref

  4. Samsonova Olga, Glinca Serghei, Biela Adam, Pfeiffer Christian, Dayyoub Eyas, Sahin Damla, Klebe Gerhard, Kissel Thomas, The use of isothermal titration calorimetry and molecular dynamics to show variability in DNA transfection performance, Acta Biomaterialia, 9, 2, 2013. Crossref

  5. Young Kim Jin, Ryu Jae Hwan, Hyun Hyesun, Kim Hyun Ah, Sig Choi Joon, Yun Lee Dong, Rhim Taiyoun, Park Jeong Hyun, Lee Minhyung, Dexamethasone conjugation to polyamidoamine dendrimers G1 and G2 for enhanced transfection efficiency with an anti-inflammatory effect, Journal of Drug Targeting, 20, 8, 2012. Crossref

  6. Mishra Deepa, Kang Han Chang, Bae You Han, Reconstitutable charged polymeric (PLGA)2-b-PEI micelles for gene therapeutics delivery, Biomaterials, 32, 15, 2011. Crossref

  7. Rhim Taiyoun, Lee Dong Yun, Lee Minhyung, Drug Delivery Systems for the Treatment of Ischemic Stroke, Pharmaceutical Research, 30, 10, 2013. Crossref

  8. Kang H. C., Bae Y. H., pH-Tunable Endosomolytic Oligomers for Enhanced Nucleic Acid Delivery, Advanced Functional Materials, 17, 8, 2007. Crossref

  9. Mishra Deepa, Kang Han Chang, Cho Hana, Bae You Han, Dexamethasone-Loaded Reconstitutable Charged Polymeric (PLGA)n-b-bPEI Micelles for Enhanced Nuclear Delivery of Gene Therapeutics, Macromolecular Bioscience, 14, 6, 2014. Crossref

  10. Kim Hyunjung, Kim Hyun Ah, Bae Yun Mi, Choi Joon Sig, Lee Minhyung, Dexamethasone-conjugated polyethylenimine as an efficient gene carrier with an anti-apoptotic effect to cardiomyocytes, The Journal of Gene Medicine, 11, 6, 2009. Crossref

  11. Beloor Jagadish, Choi Chang Seon, Nam Hye Yeong, Park Minsun, Kim Sung Hwa, Jackson Andrew, Lee Kuen Yong, Kim Sung Wan, Kumar Priti, Lee Sang-Kyung, Arginine-engrafted biodegradable polymer for the systemic delivery of therapeutic siRNA, Biomaterials, 33, 5, 2012. Crossref

  12. Kang Han Chang, Bae You Han, Polymeric Gene Transfection on Insulin-Secreting Cells: Sulfonylurea Receptor-Mediation and Transfection Medium Effect, Pharmaceutical Research, 23, 8, 2006. Crossref

  13. Kang Han Chang, Samsonova Olga, Kang Sun-Woong, Bae You Han, The effect of environmental pH on polymeric transfection efficiency, Biomaterials, 33, 5, 2012. Crossref

  14. Kim Hyunjung, Bae Yun Mi, Kim Hyun Ah, Hyun Hyesun, Yu Gwang Sig, Choi Joon Sig, Lee Minhyung, Synthesis and characterization of dexamethasone-conjugated linear polyethylenimine as a gene carrier, Journal of Cellular Biochemistry, 110, 3, 2010. Crossref

  15. Han Jee Seung, Kim Hyun Ah, Lee Sanghyun, Lee Minhyung, VEGF receptor binding peptide-linked high mobility box group-1 box A as a targeting gene carrier for hypoxic endothelial cells, Journal of Cellular Biochemistry, 110, 5, 2010. Crossref

  16. Kariduraganavar Mahadevappa Y., Kittur Arjumand A., Kamble Ravindra R., Polymer Synthesis and Processing, in Natural and Synthetic Biomedical Polymers, 2014. Crossref

  17. Lee Minhyung, Choi Joon Sig, Ko Kyung Soo, Mitochondria targeting delivery of nucleic acids, Expert Opinion on Drug Delivery, 5, 8, 2008. Crossref

  18. Ryu Jaehwan, Jeon Pureum, Lee Minhyung, R3V6 Amphiphilic Peptide with High Mobility Group Box 1A Domain as an Efficient Carrier for Gene Delivery, Bulletin of the Korean Chemical Society, 34, 12, 2013. Crossref

  19. Mateos-Timoneda Miguel A., Lok Martin C., Hennink Wim E., Feijen Jan, Engbersen Johan F. J., Poly(amido amine)s as Gene Delivery Vectors: Effects of Quaternary Nicotinamide Moieties in the Side Chains, ChemMedChem, 3, 3, 2008. Crossref

  20. Han Jee Seung, Kim Kyunghwa, Lee Minhyung, A high mobility group B-1 box A peptide combined with an artery wall binding peptide targets delivery of nucleic acids to smooth muscle cells, Journal of Cellular Biochemistry, 107, 1, 2009. Crossref

  21. Kim Kyunghwa, Han Jee Seung, Kim Hyun Ah, Lee Minhyung, Expression, purification and characterization of TAT-high mobility group box-1A peptide as a carrier of nucleic acids, Biotechnology Letters, 30, 8, 2008. Crossref

  22. Holladay C., Keeney M., Newland B., Mathew A., Wang W., Pandit A., A reliable method for detecting complexed DNA in vitro, Nanoscale, 2, 12, 2010. Crossref

  23. Kang Han Chang, Bae You Han, Endolysosomolytically Active pH-Sensitive Polymeric Nanotechnology, in Organelle-Specific Pharmaceutical Nanotechnology, 2010. Crossref

  24. Chang Kang Han, Bae You Han, Co-delivery of small interfering RNA and plasmid DNA using a polymeric vector incorporating endosomolytic oligomeric sulfonamide, Biomaterials, 32, 21, 2011. Crossref

  25. Oh Binna, Han Jaesik, Choi Eunji, Tan Xiaonan, Lee Minhyung, Peptide Micelle-Mediated Delivery of Tissue-Specific Suicide Gene and Combined Therapy with Avastin in a Glioblastoma Model, Journal of Pharmaceutical Sciences, 104, 4, 2015. Crossref

  26. Jeon Pureum, Choi Manbok, Oh Jungju, Lee Minhyung, Dexamethasone-Conjugated Polyamidoamine Dendrimer for Delivery of the Heme Oxygenase-1 Gene into the Ischemic Brain, Macromolecular Bioscience, 15, 7, 2015. Crossref

  27. Kang Han Chang, Bae You Han, Transfection of insulin-secreting cell line and rat islets by functional polymeric gene vector, Biomaterials, 30, 14, 2009. Crossref

  28. Kang Han Chang, Samsonova Olga, Bae You Han, Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells, Biomaterials, 31, 11, 2010. Crossref

  29. KC Remant Bahadur, Kucharski Cezary, Uludağ Hasan, Additive nanocomplexes of cationic lipopolymers for improved non-viral gene delivery to mesenchymal stem cells, Journal of Materials Chemistry B, 3, 19, 2015. Crossref

  30. Lee Jiyoung, Hyun Hyesun, Kim Hyun Ah, Lee Minhyung, Dexamethasone loaded r3v6 peptide micelles for gene delivery, Journal of Controlled Release, 152, 2011. Crossref

  31. Kim Hyun Ah, Lee Byung-Wan, Kang Dongchul, Kim Jae Hyeon, Ihm Sung Hee, Lee Minhyung, Delivery of hypoxia-inducible VEGF gene to rat islets using polyethylenimine, Journal of Drug Targeting, 17, 1, 2009. Crossref

  32. Lee Sanghyun, Song Hojung, Kim Hyun Ah, Oh Binna, Lee Dong Yun, Lee Minhyung, The box a domain of high mobility group box-1 protein as an efficient siRNA carrier with anti-inflammatory effects, Journal of Cellular Biochemistry, 113, 1, 2012. Crossref

  33. Kang Han Chang, Kang Ho-Jung, Bae You Han, A reducible polycationic gene vector derived from thiolated low molecular weight branched polyethyleneimine linked by 2-iminothiolane, Biomaterials, 32, 4, 2011. Crossref

  34. Lee Suyeon, Kim Kyunghwa, Kim Hyun Ah, Kim Sung Wan, Lee Minhyung, Augmentation of erythropoietin enhancer-mediated hypoxia-inducible gene expression by co-transfection of a plasmid encoding hypoxia-inducible factor 1α for ischemic tissue targeting gene therapy, Journal of Drug Targeting, 16, 1, 2008. Crossref

  35. Kim Hyun Ah, Park Ji Hwan, Cho Su Hee, Lee Minhyung, Lung epithelial binding peptide-linked high mobility group box-1 A box for lung epithelial cell-specific delivery of DNA, Journal of Drug Targeting, 19, 7, 2011. Crossref

  36. Ryu Dong-Wook, Kim Hyun Ah, Song Hojung, Kim Soonhag, Lee Minhyung, Amphiphilic peptides with arginines and valines for the delivery of plasmid DNA, Journal of Cellular Biochemistry, 112, 5, 2011. Crossref

  37. Rosenkranz A. A., Sobolev A. S., Polyethylenimine-based polyplex nanoparticles and features of their behavior in cells and tissues, Russian Chemical Bulletin, 64, 12, 2015. Crossref

  38. Lee Bo Reum, Baik Hye Jung, Oh Nam Muk, Lee Eun Seong, Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment, Polymers, 2, 2, 2010. Crossref

  39. Ongkudon Clarence M., Ho Jenny, Danquah Michael K., Mitigating the looming vaccine crisis: production and delivery of plasmid-based vaccines, Critical Reviews in Biotechnology, 31, 1, 2011. Crossref

  40. Choi Manbok, Oh Jungju, Rhim Taiyoun, Lee Minhyung, Delivery of Hypoxia-Inducible Heme Oxygenase-1 Gene for Site-Specific Gene Therapy in the Ischemic Stroke Animal Model, Pharmaceutical Research, 33, 9, 2016. Crossref

  41. Rhim Taiyoun, Lee Minhyung, Targeted delivery of growth factors in ischemic stroke animal models, Expert Opinion on Drug Delivery, 13, 5, 2016. Crossref

  42. Tian Li, Lu Linfeng, Qiao Yang, Ravi Saisree, Salatan Ferandre, Melancon Marites, Stimuli-Responsive Gold Nanoparticles for Cancer Diagnosis and Therapy, Journal of Functional Biomaterials, 7, 3, 2016. Crossref

  43. Hsueh Yu-Sheng, Subramaniam Sadhasivam, Tseng Yi-Cheng, Chiang Te-Ming, Mestak Ondrej, Cheng Teng-Kuei, Kuo Tzong-Fu, Sivasubramanian Savitha, Lin Feng-Huei, Shieh Ming-Jium, In vitro and in vivo assessment of chitosan modified urocanic acid as gene carrier, Materials Science and Engineering: C, 70, 2017. Crossref

  44. Oh Jungju, Lee Min Sang, Jeong Ji Hoon, Lee Minhyung, Deoxycholic Acid–Conjugated Polyethylenimine for Delivery of Heme Oxygenase-1 Gene in Rat Ischemic Stroke Model, Journal of Pharmaceutical Sciences, 106, 12, 2017. Crossref

  45. Mesken J., Iltzsche A., Mulac D., Langer K., Modifying plasmid-loaded HSA-nanoparticles with cell penetrating peptides – Cellular uptake and enhanced gene delivery, International Journal of Pharmaceutics, 522, 1-2, 2017. Crossref

  46. Kang Han Chang, Lee Eun Seong, Na Kun, Bae You Han, Stimuli-Sensitive Nanosystems: For Drug and Gene Delivery, in Multifunctional Pharmaceutical Nanocarriers, 4, 2008. Crossref

  47. Kim Kyoungnam, Ryu Kitae, Cho Hana, Shim Min Suk, Cho Yong-Yeon, Lee Joo Young, Lee Hye Suk, Kang Han Chang, Effects of Decomplexation Rates on Ternary Gene Complex Transfection with α-Poly(l-Lysine) or ε-Poly(l-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell, Pharmaceutics, 12, 6, 2020. Crossref

  48. Chapter Physiological Stress Responsive Gene Regulation Systems for Tissue Targeting, in Targeted Delivery of Small and Macromolecular Drugs, 2010. Crossref

  49. Lee Youngki, Lee Jeil, Kim Minkyung, Kim GyeungYun, Choi Joon Sig, Lee Minhyung, Brain gene delivery using histidine and arginine-modified dendrimers for ischemic stroke therapy, Journal of Controlled Release, 330, 2021. Crossref

  50. Hwang Hee Sook, Kang Han Chang, Bae You Han, Bioreducible Polymers As a Determining Factor for Polyplex Decomplexation Rate and Transfection, Biomacromolecules, 14, 2, 2013. Crossref

  51. Tian Li, Kang Han Chang, Bae You Han, Endosomolytic Reducible Polymeric Electrolytes for Cytosolic Protein Delivery, Biomacromolecules, 14, 8, 2013. Crossref

  52. Cutlar Lara, Zhou Dezhong, Gao Yongsheng, Zhao Tianyu, Greiser Udo, Wang Wei, Wang Wenxin, Highly Branched Poly(β-Amino Esters): Synthesis and Application in Gene Delivery, Biomacromolecules, 16, 9, 2015. Crossref

  53. Hamada Eri, Kurosaki Tomoaki, Hashizume Junya, Harasawa Hitomi, Nakagawa Hiroo, Nakamura Tadahiro, Kodama Yukinobu, Sasaki Hitoshi, Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery, Pharmaceutics, 13, 1, 2021. Crossref

  54. Yim Hyeona, Na Kun, Polycationic Nanodrug Covered with Hyaluronic Acid for Treatment of P-Glycoprotein Overexpressing Cancer Cells, Biomacromolecules, 11, 9, 2010. Crossref

  55. Look Jennifer, Wilhelm Nadine, von Briesen Hagen, Noske Nadja, Günther Christine, Langer Klaus, Gorjup Erwin, Ligand-Modified Human Serum Albumin Nanoparticles for Enhanced Gene Delivery, Molecular Pharmaceutics, 12, 9, 2015. Crossref

  56. Choi Myoungjee, Thuy Le Thi, Lee Youngki, Piao Chunxian, Choi Joon Sig, Lee Minhyung, Dual-Functional Dendrimer Micelles with Glycyrrhizic Acid for Anti-Inflammatory Therapy of Acute Lung Injury, ACS Applied Materials & Interfaces, 13, 40, 2021. Crossref

  57. Mandal Dipika, Paul Paramita, Bhowmik Manas, Stimulus-responsive gold nanotheranostic platforms for targeting the tumor microenvironment, in Multifunctional Theranostic Nanomedicines in Cancer, 2021. Crossref

  58. Cho Hana, Cho Young-Woo, Kang Sun-Woong, Kwak Mi-Kyoung, Huh Kang Moo, Bae You Han, Kang Han Chang, Tempo-spatial Activation of Sequential Quadruple Stimuli for High Gene Expression of Polymeric Gene Nanocomplexes, Molecular Pharmaceutics, 14, 3, 2017. Crossref

  59. Tamboli Viral, Mishra Gyan P, Mitra Ashim K, Polymeric vectors for ocular gene delivery, Therapeutic Delivery, 2, 4, 2011. Crossref

  60. Hwang Hee Sook, Hu Jun, Na Kun, Bae You Han, Role of Polymeric Endosomolytic Agents in Gene Transfection: A Comparative Study of Poly(l-lysine) Grafted with Monomeric l-Histidine Analogue and Poly(l-histidine), Biomacromolecules, 15, 10, 2014. Crossref

  61. Kim Kyoungnam, Ryu Kitae, Choi Yeon Su, Cho Yong-Yeon, Lee Joo Young, Lee Hye Suk, Chang Kang Han, Effects of the Physicochemical, Colloidal, and Biological Characteristics of Different Polymer Structures between α-Poly(l-lysine) and ε-Poly(l-lysine) on Polymeric Gene Delivery, Biomacromolecules, 19, 7, 2018. Crossref

  62. Han Sangrok, Lee Youngki, Lee Minhyung, Biomimetic cell membrane-coated DNA nanoparticles for gene delivery to glioblastoma, Journal of Controlled Release, 338, 2021. Crossref

  63. Kim Hyun Ah, Park Ji Hwan, Lee Sanghyun, Choi Joon Sig, Rhim Taiyoun, Lee Minhyung, Combined delivery of dexamethasone and plasmid DNA in an animal model of LPS-induced acute lung injury, Journal of Controlled Release, 156, 1, 2011. Crossref

  64. Park Ji Hwan, Kim Hyun Ah, Park Jin Hyeong, Lee Minhyung, Amphiphilic peptide carrier for the combined delivery of curcumin and plasmid DNA into the lungs, Biomaterials, 33, 27, 2012. Crossref

  65. Kim Kyunghwa, Han Jee Seung, Park Jeong Hyun, Ko Kyung Soo, Lee Minhyung, Expression and characterization of a recombinant high mobility group box 1 AB peptide with a 6-histidine tag for delivery of nucleic acids, Enzyme and Microbial Technology, 43, 6, 2008. Crossref

  66. Rhim Taiyoun, Lee Dong Yun, Lee Minhyung, Hypoxia as a target for tissue specific gene therapy, Journal of Controlled Release, 172, 2, 2013. Crossref

  67. Kang Han Chang, Huh Kang Moo, Bae You Han, Polymeric nucleic acid carriers: current issues and novel design approaches, Journal of Controlled Release, 164, 3, 2012. Crossref

  68. Kim Hyun Ah, Rhim Taiyoun, Lee Minhyung, Regulatory systems for hypoxia-inducible gene expression in ischemic heart disease gene therapy, Advanced Drug Delivery Reviews, 63, 8, 2011. Crossref

  69. Choi Eunji, Oh Jungju, Lee Dahee, Lee Jaewon, Tan Xiaonan, Kim Minkyung, Kim Gyeungyun, Piao Chunxian, Lee Minhyung, A ternary-complex of a suicide gene, a RAGE-binding peptide, and polyethylenimine as a gene delivery system with anti-tumor and anti-angiogenic dual effects in glioblastoma, Journal of Controlled Release, 279, 2018. Crossref

  70. Lee Jiyoung, Hyun Hyesun, Kim Jinyoung, Ryu Jae Hwan, Kim Hyun Ah, Park Ji Hwan, Lee Minhyung, Dexamethasone-loaded peptide micelles for delivery of the heme oxygenase-1 gene to ischemic brain, Journal of Controlled Release, 158, 1, 2012. Crossref

  71. Gjetting Torben, Andresen Thomas Lars, Christensen Camilla Laulund, Cramer Frederik, Poulsen Thomas Tuxen, Poulsen Hans Skovgaard, A simple protocol for preparation of a liposomal vesicle with encapsulated plasmid DNA that mediate high accumulation and reporter gene activity in tumor tissue, Results in Pharma Sciences, 1, 1, 2011. Crossref

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