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International Journal of Physiology and Pathophysiology

年間 4 号発行

ISSN 印刷: 2155-014X

ISSN オンライン: 2155-0158

SJR: 0.116

Increased Sensitivity of Mitochondrial Permeability Transition Pore to Ca2+ in the Heart of Spontaneously Hypertensive Rats

巻 4, 発行 3, 2013, pp. 245-251
DOI: 10.1615/IntJPhysPathophys.v4.i3.60
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要約

In vitro experiments on the mitochondria isolated from adult normotensive and spontaneously hypertensive rat hearts, an increased sensitivity of mitochondrial permeability transition pore (mPTP) to Ca2+, its natural inducer, has been revealed. In spontaneously hypertensive rats, it is evoked by the reduction of active ion concentration by two orders, which causes organelle swelling. Calcium-induced swelling of the mitochondria isolated from the normotensive rats (control) is completely prevented by cyclosporin A (10−5 mol/l), a natural mPTP inhibitor, while in spontaneously hypertensive rats, it is prevented only partially (by 54%), indicating the presence of cyclosporin A-insensitive mPTP component. The results obtained give reason to conclude that hypertension is associated with mitochondrial dysfunction, characterized, in particular, by increased mPTP sensitivity to Ca2+, which may elicit widespread tissue damage, accompanying diseases of the cardiovascular system, especially hypertension.

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