年間 4 号発行
ISSN 印刷: 2155-014X
ISSN オンライン: 2155-0158
Antiatherogenic Property of 'Corvitin': Effect on Proteasome Activity in Aorta, Heart and Blood Cells
要約
We studied the changes in proteasomal proteolysis during modeling of rabbit cholesterol-induced atherosclerosis. It was determined that in aorta the TL activity of proteasome increased 2.4-fold (Р < 0.05), the ChTP activity increased by 43%, and the PGPG − by 10%. In heart tissue it was observed the increase of the ChTP proteasome activity by 14%. The application of 'Corvitin' (water-soluble form of quercetin) followed by considerable decrease of proteasomal activity both in tissues (aorta and heart) and leucocytes. The intensity of atherosclerotic changes in aorta was significantly smaller. Obtained data suggest that 'Corvitin' reveales angioprotective properties mediated by it effect on proteasomal proteolysis.
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Tkachenko V., Kovalchuk Y., Bondarenko N., Bondarenko О., Ushakova G., Shevtsova A., The Cardio- and Neuroprotective Effects of Corvitin and 2-Oxoglutarate in Rats with Pituitrin-Isoproterenol-Induced Myocardial Damage, Biochemistry Research International, 2018, 2018. Crossref