年間 4 号発行
ISSN 印刷: 2155-014X
ISSN オンライン: 2155-0158
Mitochondria Signaling in Adaptation to Hypoxia
要約
A bioenergetic mechanism for development of urgent adaptation to hypoxia is considered. Hypoxia induces reprogramming of respiratory chain function and switching from oxidation of NAD-related substrates (complex I) to succinate oxidation (complex II). Transient, reversible, compensatory activation of respiratory chain complex II is a major mechanism of urgent adaptation to hypoxia necessary for 1) succinate-related energy synthesis in conditions of oxygen deficiency and formation of urgent resistance in the body; 2) succinate-related stabilization of HIF-1 α and initiation of its transcriptional activity related with formation of urgent and long-term adaptation; 3) succinate-related activation of a succinate-specific receptor GPR91. Therefore, succinate is a signaling molecule, and its effects are realized at three levels in hypoxia, intramitochondrial, intracellular and intercellular.
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Lukyanova Ludmila, Germanova Elita, Khmil Natalya, Pavlik Lybov, Mikheeva Irina, Shigaeva Maria, Mironova Galina, Signaling Role of Mitochondrial Enzymes and Ultrastructure in the Formation of Molecular Mechanisms of Adaptation to Hypoxia, International Journal of Molecular Sciences, 22, 16, 2021. Crossref
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