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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Scientific Validation of the Chinese Caterpillar Medicinal Mushroom, Ophiocordyceps sinensis (Ascomycetes) from India: Immunomodulatory and Antioxidant Activity

巻 16, 発行 6, 2014, pp. 541-553
DOI: 10.1615/IntJMedMushrooms.v16.i6.40
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要約

In the present study, we aimed to elucidate the antioxidant property and anti-inflammatory activity of the aqueous extract of the Indian species of Ophiocordyceps sinensis (AECS), which demonstrates medicinal activity against numerous diseases. The chemical composition of AECS was quantified using a colorimeteric technique to determine the total phenolic and flavonoid contents. Antioxidant activity was determined by assays for 2,2'-azinobis(3-ethylbenzothiazoline-6-sulphonic acid)diammonium salt (ABTS); 2,2-diphenyl-1-picryl-hydrazyl (DPPH); and ferric reducing antioxidant power (FRAP). Adenosine nucleoside and nitrogenous bases (adenine and uracil) were also quantified by high-performance thin layer chromatography (HPTLC). Furthermore, the aqueous extract was also analyzed for anti-inflammatory activity in vitro using THP1 cells. THP1 cells were treated with and without lipopolysaccharide (LPS) and AECS (at 25 µg/mL, 50 µg/mL and 100 µg/mL, respectively) for 24 h. After 24 h, supernatants were harvested and kept at −80°C until the cytokine assays were performed. Furthermore, nitric oxide (NO) content was also estimated in treated and untreated murine peritoneal macrophages using Griess reagent. AECS significantly suppressed LPS-induced release of TNF-α and IL-1β in THP1 cells and significantly suppressed NO release in macrophage cells without exerting any toxic effect. These results indicate the anti-inflammatory activity of AECS. Additionally, this extract also has an antioxidant property, as high contents of phenols and flavonoids are present in the extract with considerable reducing power. The results of this study clearly demonstrate the potent antioxidant property and anti-inflammatory activity of AECS. Therefore, consumption of AECS may be clinically useful to protect against inflammatory diseases.

によって引用された
  1. Luo Ying, Yang Shi-kun, Zhou Xun, Wang Ming, Tang Dan, Liu Fu-you, Sun Lin, Xiao Li, Use ofOphiocordyceps sinensis(syn.Cordyceps sinensis) combined with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) versus ACEI/ARB alone in the treatment of diabetic kidney disease: a meta-analysis, Renal Failure, 37, 4, 2015. Crossref

  2. Cheng Ruo-Lin, Yu Yong-Xin, Liu Ling-Xiao, Zhang Chuan-Xi, Fang Cheng-Xiang, A draft genome of the ghost moth,Thitarodes(Hepialus) sp., a medicinal caterpillar fungus, Insect Science, 23, 2, 2016. Crossref

  3. Pal Mamta, Misra Kshipra, Cordyceps sp.: The Precious Mushroom for High-Altitude Maladies, in Management of High Altitude Pathophysiology, 2018. Crossref

  4. Shi Hui, Zhang Min, Devahastin Sakamon, New Development of Efficient Processing Techniques on Typical Medicinal Fungi: A Review, Food Reviews International, 36, 1, 2020. Crossref

  5. Luitel Himal, Novoyatleva Tatyana, Sydykov Akylbek, Petrovic Aleksandar, Mamazhakypov Argen, Devkota Bhuminand, Wygrecka Malgorzata, Ghofrani Hossein Ardeschir, Avdeev Sergey, Schermuly Ralph Theo, Kosanovic Djuro, Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties, Medicina, 56, 3, 2020. Crossref

  6. Liu Wu, Gao Yiwei, Zhou Yi, Yu Fangning, Li Xinyi, Zhang Ning, Mechanism of Cordyceps sinensis and its Extracts in the Treatment of Diabetic Kidney Disease: A Review, Frontiers in Pharmacology, 13, 2022. Crossref

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