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International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Diverse Effects of the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Combination with Tamoxifen Citrate and Doxorubicin in MCF-7 Breast Cancer Cells

巻 18, 発行 6, 2016, pp. 489-499
DOI: 10.1615/IntJMedMushrooms.v18.i6.30
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要約

Ganoderma lucidum, a medicinal mushroom, has been known to have antimetastatic and anticarcinogenic bioactivities and is widely used in Asian countries in complementary and alternative medicine. However, there is no information regarding its combined usage with tamoxifen and doxorubicin in breast cancer treatment. We investigated the interactions between G. lucidum and tamoxifen or doxorubicin in an MCF-7 human estrogen receptorpositive breast cancer cell line. The antiproliferative properties of 6 extracts were assessed using the WST-8 method. The most effective extract in inhibiting MCF-7 cell viability was then evaluated in terms of its antimetastatic activity by the Boyden chamber assay. Apoptosis and cell cycle assays were performed by flow cytometry. G. lucidum ether extract (G.Ether) was the most effective extract in inhibiting cell viability, among other extracts, with half-maximal inhibitory concentrations of 100 and 12.82 μg/mL at 48 and 72 hours, respectively. We found that G.Ether is capable of inducing apoptosis and changing cell cycle dynamics. However, incubation with G.Ether did not significantly affect MCF-7 cell motility. We then assessed the interactions between G.Ether and tamoxifen or doxorubicin in MCF-7 cells. The interactions between G.Ether and cancer therapeutics were examined by combination index analysis and MacSynergy II software. Interestingly, G.Ether increased the antiproliferative effect of tamoxifen but exhibited strong antagonism with doxorubicin in the MCF-7 cell line.

によって引用された
  1. Suárez-Arroyo Ivette, Loperena-Alvarez Yaliz, Rosario-Acevedo Raysa, Martínez-Montemayor Michelle, Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer, Medicines, 4, 1, 2017. Crossref

  2. Ahmad Md Faruque, Ganoderma lucidum: A rational pharmacological approach to surmount cancer, Journal of Ethnopharmacology, 260, 2020. Crossref

  3. Salvatore Maria Michela, De Gregorio Vincenza, Gallo Monica, Corsaro Maria Michela, Casillo Angela, Vecchione Raffaele, Andolfi Anna, Naviglio Daniele, Netti Paolo Antonio, Evaluation of Two Extraction Methods for the Analysis of Hydrophilic Low Molecular Weight Compounds from Ganoderma lucidum Spores and Antiproliferative Activity on Human Cell Lines, Applied Sciences, 10, 11, 2020. Crossref

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