年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
Indexed in
A 90-Day Subchronic Toxicity Study of Submerged Mycelial Culture of Cordyceps cicadae (Ascomycetes) in Rats
要約
Cordyceps cicadae is a parasitic fungus that hibernates inside a host (Cicada flammata Dist.) and then grows its fruiting body on the surface of the insect. The complete insect/fungus combination of C. cicadae has been widely applied in Chinese traditional medicine. Recent studies have demonstrated that the medicinal benefits of cultured mycelia are as effective as those found in the wild. However, toxicological information regarding the chronic consumption of C. cicadae mycelia culture is not available. This study was conducted to evaluate the possible toxicity arising from repeated exposure to freeze-dried submerged mycelial culture of C. cicadae for 90 days. A total of eighty 8-week-old Sprague-Dawley rats were divided into 4 groups (10 males and 10 females in each group). C. cicadae was administered daily to animals by gavage at doses of 0, 500, 1000, and 2000 mg/kg body weight for 90 days. No animal deaths occurred and no treatment-related clinical signs were observed during the study period. No statistical differences in body weight gain, relative organ weight, hematology, serum chemistry, and urinalysis were observed. Gross necropsy and histopathological findings indicated that there was no treatment-related abnormality. Based on the results, the no observed adverse effect level of C. cicadae whole broth is determined to be > 2000 mg/kg for male and female Sprague-Dawley rats. The results of this study provides support for the use of C. cicadae fermentation product as a safe agent in functional food.
-
林 明义, A Acute Toxicity Study of Cordyceps cicadae Mycelium in ICR Mice and SD Rats, Hans Journal of Food and Nutrition Science, 06, 02, 2017. Crossref
-
Li I-Chen, Lin Shan, Tsai Yueh-Ting, Hsu Jui-Hsia, Chen Yen-Lien, Lin Wen-Hsin, Chen Chin-Chu, Cordyceps cicadae mycelia and its active compound HEA exert beneficial effects on blood glucose in type 2 diabetic db/db mice, Journal of the Science of Food and Agriculture, 99, 2, 2019. Crossref
-
Xie Hongqing, Li Xiaotong, Chen Yajie, Lang Mingzi, Shen Zhangfei, Shi Liangen, Ethanolic extract of Cordyceps cicadae exerts antitumor effect on human gastric cancer SGC-7901 cells by inducing apoptosis, cell cycle arrest and endoplasmic reticulum stress, Journal of Ethnopharmacology, 231, 2019. Crossref
-
Zhang Xiaofeng, Hu Qiongbo, Weng Qunfang, Secondary metabolites (SMs) of Isaria cicadae and Isaria tenuipes, RSC Advances, 9, 1, 2019. Crossref
-
Liu Ru-Ming, Dai Rong, Luo Yi, Xiao Jian-Hui, Glucose-lowering and hypolipidemic activities of polysaccharides from Cordyceps taii in streptozotocin-induced diabetic mice, BMC Complementary and Alternative Medicine, 19, 1, 2019. Crossref
-
Deng Jeng-Shyan, Jiang Wen-Ping, Chen Chin-Chu, Lee Li-Ya, Li Pei-Ying, Huang Wen-Chin, Liao Jung-Chun, Chen Hung-Yi, Huang Shyh-Shyun, Huang Guan-Jhong, Cordyceps cicadae Mycelia Ameliorate Cisplatin-Induced Acute Kidney Injury by Suppressing the TLR4/NF-κB/MAPK and Activating the HO-1/Nrf2 and Sirt-1/AMPK Pathways in Mice, Oxidative Medicine and Cellular Longevity, 2020, 2020. Crossref
-
Tsai You-Shan, Hsu Jui-Hsia, Lin David Pei-Cheng, Chang Han-Hsin, Chang Wen-Jui, Chen Yen-Lien, Chen Chin-Chu, Safety Assessment of HEA-Enriched Cordyceps cicadae Mycelium: A Randomized Clinical Trial, Journal of the American College of Nutrition, 40, 2, 2021. Crossref
-
Fu Hsin‐I, Hsu Jui‐Hsia, Li Tsung‐Ju, Yeh Shu‐Hsing, Chen Chin‐Chu, Safety assessment of HEA‐enriched Cordyceps cicadae mycelia on the central nervous system (CNS), cardiovascular system, and respiratory system in ICR male mice , Food Science & Nutrition, 9, 9, 2021. Crossref
-
徐 瑞霞, Intraocular Pressure-Lowering Efficacy and Safety of Fermented Cordyceps cicadae Mycelia, Hans Journal of Food and Nutrition Science, 10, 01, 2021. Crossref
-
Lee Li-Ya, Hsu Jui-Hsia, Fu Hsin-I, Chen Chin-Chu, Tung Kwong-Chung, Lowering the Intraocular Pressure in Rats and Rabbits by Cordyceps cicadae Extract and Its Active Compounds, Molecules, 27, 3, 2022. Crossref
-
Chiu Ching-Peng, Hwang Tsong-Long, Chan You, El-Shazly Mohamed, Wu Tung-Ying, Lo I-Wen, Hsu Yu-Ming, Lai Kuei-Hung, Hou Ming-Feng, Yuan Shyng-Shiou, Chang Fang-Rong, Wu Yang-Chang, Research and development of Cordyceps in Taiwan, Food Science and Human Wellness, 5, 4, 2016. Crossref
-
Hsu Jui-Hsia, Chang Wen-Jui, Fu Hsin-I, Chang Han-Hsin, Chen Chin-Chu, Clinical evaluation of the short-term effects of Cordyceps cicadae mycelium in lowering intraocular pressure, Journal of Functional Foods, 95, 2022. Crossref