年間 12 号発行
ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344
Indexed in
Assessment of the Gastroprotective Effect of the Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Against the Gastric Mucosal Ulceration Induced by Ethanol in Experimental Rats
要約
The chaga medicinal mushroom (Inonotus obliquus) was traditionally used to treat various ailments. To establish the pharmacological properties of I. obliquus, studies were performed to show the antiulcer activity of the ethanolic extract. The ethanolic extract of I. obliquus was prepared. The antiulcer activity of I. obliquus was determined using gastric ulcerated rats (ulceration induced by ethanol). The ethanolic extract of I. obliquus (200 mg/kg) did not cause any sign of toxicity or sensitivity to rats when the extracts were administered by oral feed. Oral administration of ethanolic extract of I. obliquus exhibited antiulcer activity in all models used. The ethanolic extract of I. obliquus showed an effective antiulcer activity, which could be due to the presence of various biologically active compounds. This confirmed the traditional uses of I. obliquus in the treatment of ailments.
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El-Maraghy SA, Rizk SM, Shahin NN. Gastroprotective effect of crocin in ethanol-induced gastric injury in rats. Chem Biol Interact. 2015;229:26-35.
-
Bansil R, Turner BS. The biology of mucus: composition, synthesis and organization. Adv Drug Deliv. Rev. 2018;124:3-15.
-
Yandrapu H, Sarosiek J. Protective factors of the gastric and duodenal mucosa: an overview. Curr Gastroenterol Rep. 2015;17(6):24.
-
Hajrezaie M, Golbabapour S, Hassandarvish P, Gwaram NS, Hadi AH, Ali HM, Majid N, Abdulla MA. Acute toxicity and gastroprotection studies of a new Schiff base derived copper (II) complex against ethanol-induced acute gastric lesions in rats. PloS One. 2012;7(12):e51537.
-
Ketuly KA, Hadi AH, Golbabapour S, Hajrezaie M, Hassandarvish P, Ali HM, Majid NA, Abdulla MA. Acute toxicity and gastroprotection studies with a newly synthesized steroid. PloS One. 2013;8(3):e59296.
-
Srinivas TL, Lakshmi SM, Shama SN, Reddy GK, Prasanna KR. Medicinal plants as anti-ulcer agents. J Pharmacogn Phytochem. 2013;2(4):91-7.
-
Wasser SP. Medicinal mushroom science: history, current status, future trends, and unsolved problems. Int J Med Mushrooms. 2010;12(1):1-16.
-
Wasser S. Medicinal mushroom science: Current perspectives, advances, evidences, and challenges. Biomedical J. 2014;1;37(6):345-56.
-
Vitak TY, Wasser SP, Nevo E, Sybirna NO. The effect of the medicinal mushrooms Agaricus brasiliensis and Ganoderma lucidum (higher Basidiomycetes) on the erythron system in normal and streptozotocin-induced diabetic rats. Int J Med Mushrooms. 2015;17(3):277-86.
-
Rouhana-Toubi A, Wasser SP, Fares F. The shaggy ink cap medicinal mushroom, Coprinus comatus (higher Basidiomycetes) extract induces apoptosis in ovarian cancer cells via extrinsic and intrinsic apoptotic pathways. Int J Med Mushrooms. 2015;17(12):1127-36.
-
Yurkiv B, Wasser SP, Nevo E, Sybirna NO. Antioxidant effects of medicinal mushrooms Agaricus brasiliensis and Ganoderma lucidum (higher Basidiomycetes): evidence from animal studies. Int J Med Mushrooms. 2015;17(10):943-55.
-
Lo HC, Wasser SP. Medicinal mushrooms for glycemic control in diabetes mellitus: history, current status, future perspectives, and unsolved problems. Int J Med Mushrooms. 2011;13(5):401-26.
-
Wasser SP. Medicinal mushrooms in human clinical studies. Part I. Anticancer, oncoimmunological, and immunomodulatory activities: a review. Int J Med Mushrooms. 2017;19(4):279-317.
-
Wasser SP. A book review: The Fungal Pharmacy: Medicinal Mushrooms of Western Canada. Int J Med Mushrooms. 2008;10(1):97-100.
-
Lee IK, Yun BS. Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance. J Antibiotics. 2011;64(5):349-59.
-
Chen H, Liao H, Liu Y, Zheng Y, Wu X, Su Z, Zhang X, Lai Z, Lai X, Lin ZX, Su Z. Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats. Fitoterapia. 2015;100:110-7.
-
Prino G, Paglialunga S, Nardi G, Lietti A. Inhibition of experimentally-induced gastric ulcers in the rat by a new sulfated glycopeptide. Eur J Pharmacol. 1971;15(1):119-26.
-
Srivastava SK, Nath C, Gupta MB, Vrat S, Sinha JN, Dhawan KN, Gupta GP. Protection against gastric ulcer by verapamil. Pharmacol Res. 1991;23(1):81-6.
-
Yildirim A, Sahin YN, Suleyman H, Yilmaz A, Yildirim S. The role of prednisolone and epinephrine on gastric tissue and erythrocyte antioxidant status in adrenalectomized rats. J Physiol Pharmacol. 2007;58:105-16.
-
Ayala A, Munoz MF, Arguelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014;2014:360438. doi: 10.1155/2014/360438.
-
Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature. 2000;407(6802):390.
-
Beers RF, Sizer IW. A spectrophotometry method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem. 1952;195(1):133-40.
-
Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968;25:192-205.
-
Chang X, Luo F, Jiang W, Zhu L, Gao J, He H, Wei T, Gong S, Yan T. Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-KB pathway in vivo and in vitro. Int Immunopharmacol. 2015;28(1):604-15.
-
Liu Y, Tian X, Gou L, Fu X, Li S, Lan N, Yin X. Protective effect of l-citrulline against ethanol-induced gastric ulcer in rats. Environ Toxicol Phar. 2012;34(2):280-7.
-
Chang X, Luo F, Jiang W, Zhu L, Gao J, He H, Wei T, Gong S, Yan T. Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-KB pathway in vivo and in vitro. Int Immunopharmacol. 2015;28(1):604-15.
-
de Paula Ferreira M, Nishijima CM, Seito LN, Dokkedal AL, Lopes-Ferreira M, Di Stasi LC, Vilegas W, Hiruma-Lima CA. Gastroprotective effect of Cissus sicyoides (Vitaceae): involvement of microcirculation, endogenous sulfhydryls and nitric oxide. J Ethnopharmacol. 2008;117(1):170-4.
-
Kurban S, Mehmetoglu I. The effect of alcohol on total antioxidant activity and nitric oxide levels in the sera and brains of rats. Turk J Med Sci. 2008;38(3):199-204.
-
Wong KH, Sabaratnam V, Naidu M, Keynes R. Activity of aqueous extracts of lion's mane mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetidae) on the neural cell line NG108-15. Int J Med Mushrooms. 2007;9(1):57-65.
-
Chang S, Wasser S. Current and future research trends in agricultural and biomedical applications of medicinal mushrooms and mushroom products. Int J Med Mushrooms. 2018;20(12):1121-33.
-
Wang M, Konishi T, Gao Y, Xu D, Gao Q. Anti-gastric ulcer activity of polysaccharide fraction isolated from mycelium culture of lion's mane medicinal mushroom, Hericium erinaceus (higher Basidiomycetes). Int J Med Mushrooms. 2015; 17(11):1055-60.
-
Gregory M, Vithalrao KP, Gregory F, Kalaichelvan VK. Anti-ulcer (ulcer-preventive) activity of Ficus arnottiana Miq. (Moraceae) leaf methanolic extract. Am J Pharmacol Toxicol. 2009;4:89-93.
-
Shang X, Tan Q, Liu R, Yu K, Li P, Zhao GP. In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion's Mane mushroom, Hericium erinaceus (higher Basidiomycetes). Int J Med Mushrooms. 2013;15(2):165-74.
-
Wang J, Sun W, Luo H, He H, Deng W, Zou K, Liu C, Song J, Huang W. Protective effect of eburicoic acid of the chicken of the woods mushroom, Laetiporus sulphureus (higher Basidiomycetes), against gastric ulcers in mice. Int J Med Mushrooms. 2015;17(7):619-26.
-
Ganguly K, Sharma AV, Reiter RJ, Swarnakar S. Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. J Pineal Res. 2010;49(2):130-40.
-
Seetaha Supaphorn, Ratanabunyong Siriluk, Tabtimmai Lueacha, Choowongkomon Kiattawee, Rattanasrisomporn Jatuporn, Choengpanya Khuanjarat, Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms, Veterinary World, 13, 9, 2020. Crossref
-
Zhao Yanxia, Zheng Weifa, Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus, Journal of Ethnopharmacology, 265, 2021. Crossref
-
Câmara Neto João Francisco, Campelo Matheus da Silva, Cerqueira Gilberto Santos, de Miranda João Antônio Leal, Guedes Jhonyson Arruda Carvalho, de Almeida Raimundo Rafael, Soares Sandra de Aguiar, Gramosa Nilce Viana, Zocolo Guilherme Julião, Vieira Ícaro Gusmão Pinto, Ricardo Nágila Maria Pontes Silva, Ribeiro Maria Elenir Nobre Pinho, Gastroprotective effect of hydroalcoholic extract from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice, Journal of Ethnopharmacology, 292, 2022. Crossref