Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Melatonin Improves Behavioral and Biochemical Outcomes in a Rotenone-Induced Rat Model of Parkinson's Disease
RESUMO
Parkinson's disease (PD) is the second most common neurodegenerative disease followed only by Alzheimer's disease and affects millions of people worldwide. Despite the plethora of preclinical and clinical studies, there is currently a paucity of therapeutic agents for PD that can promote neuroprotection. In addition, the therapeutic agents currently available only help with improvement of PD symptoms. Therefore, it is imperative to find new therapeutic avenues for PD patients to minimize the economic and social burden on the concerned families. Rotenone is a frequently used neurotoxin in developing a PD model to aid in understanding the mechanisms of neuronal death. In addition, several studies have investigated the effects of melatonin, a neurohormone that is neuroprotective in various neurological diseases due to its anti-apoptotic, anti-inflammatory, and anti-oxidative properties. Our study investigated the role of melatonin-induced tyrosine hydroxylase (TH) and sensory motor function in a rotenone rat model to determine whether melatonin had any positive effects. Our results revealed that melatonin improves motor function by upregulation of TH in striatum of the brain. In addition, melatonin inhibits the striatal degeneration as shown by histopathological analysis. Therefore, results from the current study provide evidence for melatonin as a promising candidate for effective future therapeutic strategies for PD.
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Zuo , Prather , Stetskiv , Garrison , Meade , Peace , Zhou , Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments, International Journal of Molecular Sciences, 20, 18, 2019. Crossref
-
Pernold Karin, Iannello F., Low B. E., Rigamonti M., Rosati G., Scavizzi F., Wang J., Raspa M., Wiles M. V., Ulfhake B., Mintz Eric M., Towards large scale automated cage monitoring – Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique, PLOS ONE, 14, 2, 2019. Crossref
-
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-
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-
Ferlazzo Nadia, Andolina Giulia, Cannata Attilio, Costanzo Maria Giovanna, Rizzo Valentina, Currò Monica, Ientile Riccardo, Caccamo Daniela, Is Melatonin the Cornucopia of the 21st Century?, Antioxidants, 9, 11, 2020. Crossref
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-
Salman Mohd., Tabassum Heena, Parvez Suhel, Nrf2/HO-1 mediates neuroprotective effects of pramipexole by attenuating oxidative damage and mitochondrial perturbation after traumatic brain injury, Disease Models & Mechanisms, 2020. Crossref
-
Bjørklund Geir, Dadar Maryam, Anderson George, Chirumbolo Salvatore, Maes Michael, Preventive treatments to slow substantia nigra damage and Parkinson’s disease progression: A critical perspective review, Pharmacological Research, 161, 2020. Crossref
-
Pérez-Lloret Santiago, Cardinali Daniel P., Melatonin as a Chronobiotic and Cytoprotective Agent in Parkinson’s Disease, Frontiers in Pharmacology, 12, 2021. Crossref
-
Zhou Qiuping, Lin Lanfen, Li Haiyan, Wang Huifang, Jiang Shuqi, Huang Peixian, Lin Qiongyu, Chen Xuan, Deng Yiyu, Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide, Molecular Neurobiology, 58, 12, 2021. Crossref
-
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-
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