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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Predicting the Efficacy of 5-Fluorouracil–Based Adjuvant Chemotherapy in Gastric Cancer by Microsatellite Instability: A Meta-Analysis

Volume 38, Edição 1, 2019, pp. 21-28
DOI: 10.1615/JEnvironPatholToxicolOncol.2018026876
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RESUMO

Microsatellite instability (MSI) implies the deletion of mismatch repair genes caused by DNA methylation or gene mutation. MSI is a good predictor for efficacy of 5-fluorouracil (FU)–based chemotherapy in the treatment of colorectal cancer. Some gastric cancer studies have reported that MSI has no apparent impact on prognosis after patients receive 5-FU–based adjuvant chemotherapy. However, other studies suggest that high-frequency MSI (MSI-H) status reduced survival in patients receiving 5-FU–based adjuvant chemotherapy. Thus, the correlation between MSI status and efficacy of 5-FU–based adjuvant chemotherapy for gastric cancer remains controversial. We performed a PubMed, Embase, and Cochrane search to retrieve studies that explore the correlation between MSI status and 5-FU–based adjuvant chemotherapy efficacy in gastric cancer. After extracting 65 potentially eligible studies, four were ultimately included in this meta-analysis using Stata software (ver. 12.0). For each study, we estimated the hazard ratio (HR) value for overall survival (OS), and HR was extracted per the survival curve in the studies. Heterogeneity was estimated using the random-effects model. Overall, 1174 patients after operation were included: 84 patients were classed as MSI-H and 1090 as microsatellite stable (MSS)/low-frequency MSI (MSI-L). For the four studies, the overall estimate of HR for OS between MSI-H and MSS/MSI-L groups was 1.90 (95% confidence interval: 0.91–3.93; p = 0.08). We found no correlation to exist between MSI status and efficacy of 5-FU–based adjuvant chemotherapy for gastric cancer. Although MSI can effectively predict efficacy of 5-FU–based chemotherapy in patients with colorectal cancer, the correlation between MSI status and efficacy of 5-FU–based adjuvant chemotherapy for gastric cancer remains controversial. This meta-analysis suggests that MSI status is unrelated to efficacy of 5-FU–based adjuvant chemotherapy in gastric cancer, and more prospective clinical studies are needed to further investigate predictive value of MSI status in patients with gastric cancer who, after operation, receive 5-FU–based adjuvant chemotherapy.

CITADO POR
  1. Nshizirungu Jean Paul, Bennis Sanae, Mellouki Ihsane, Benajah Dafr-Allah, Lahmidani Nada, El Bouhaddoutti Hicham, Ibn Majdoub Karim, Ibrahimi Sidi Adil, Pires Celeiro Sónia, Viana-Pereira Marta, Manuel Reis Rui, Microsatellite Instability Analysis in Gastric Carcinomas of Moroccan Patients, Genetic Testing and Molecular Biomarkers, 25, 2, 2021. Crossref

  2. Tsai Chun-Yi, Lin Tien-An, Huang Shih-Chiang, Hsu Jun-Te, Yeh Chun-Nan, Chen Tse-Ching, Chiu Cheng-Tang, Chen Jen-Shi, Yeh Ta-Sen, Is Adjuvant Chemotherapy Necessary for Patients with Deficient Mismatch Repair Gastric Cancer?—Autophagy Inhibition Matches the Mismatched, The Oncologist, 25, 7, 2020. Crossref

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