Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Predicting the Efficacy of 5-Fluorouracil–Based Adjuvant Chemotherapy in Gastric Cancer by Microsatellite Instability: A Meta-Analysis
RESUMO
Microsatellite instability (MSI) implies the deletion of mismatch repair genes caused by DNA methylation or gene mutation. MSI is a good predictor for efficacy of 5-fluorouracil (FU)–based chemotherapy in the treatment of colorectal cancer. Some gastric cancer studies have reported that MSI has no apparent impact on prognosis after patients receive 5-FU–based adjuvant chemotherapy. However, other studies suggest that high-frequency MSI (MSI-H) status reduced survival in patients receiving 5-FU–based adjuvant chemotherapy. Thus, the correlation between MSI status and efficacy of 5-FU–based adjuvant chemotherapy for gastric cancer remains controversial. We performed a PubMed, Embase, and Cochrane search to retrieve studies that explore the correlation between MSI status and 5-FU–based adjuvant chemotherapy efficacy in gastric cancer. After extracting 65 potentially eligible studies, four were ultimately included in this meta-analysis using Stata software (ver. 12.0). For each study, we estimated the hazard ratio (HR) value for overall survival (OS), and HR was extracted per the survival curve in the studies. Heterogeneity was estimated using the random-effects model. Overall, 1174 patients after operation were included: 84 patients were classed as MSI-H and 1090 as microsatellite stable (MSS)/low-frequency MSI (MSI-L). For the four studies, the overall estimate of HR for OS between MSI-H and MSS/MSI-L groups was 1.90 (95% confidence interval: 0.91–3.93; p = 0.08). We found no correlation to exist between MSI status and efficacy of 5-FU–based adjuvant chemotherapy for gastric cancer. Although MSI can effectively predict efficacy of 5-FU–based chemotherapy in patients with colorectal cancer, the correlation between MSI status and efficacy of 5-FU–based adjuvant chemotherapy for gastric cancer remains controversial. This meta-analysis suggests that MSI status is unrelated to efficacy of 5-FU–based adjuvant chemotherapy in gastric cancer, and more prospective clinical studies are needed to further investigate predictive value of MSI status in patients with gastric cancer who, after operation, receive 5-FU–based adjuvant chemotherapy.
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Nshizirungu Jean Paul, Bennis Sanae, Mellouki Ihsane, Benajah Dafr-Allah, Lahmidani Nada, El Bouhaddoutti Hicham, Ibn Majdoub Karim, Ibrahimi Sidi Adil, Pires Celeiro Sónia, Viana-Pereira Marta, Manuel Reis Rui, Microsatellite Instability Analysis in Gastric Carcinomas of Moroccan Patients, Genetic Testing and Molecular Biomarkers, 25, 2, 2021. Crossref
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Tsai Chun-Yi, Lin Tien-An, Huang Shih-Chiang, Hsu Jun-Te, Yeh Chun-Nan, Chen Tse-Ching, Chiu Cheng-Tang, Chen Jen-Shi, Yeh Ta-Sen, Is Adjuvant Chemotherapy Necessary for Patients with Deficient Mismatch Repair Gastric Cancer?—Autophagy Inhibition Matches the Mismatched, The Oncologist, 25, 7, 2020. Crossref