Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Avastin Enhances Photodynamic Therapy Treatment of Kaposi's Sarcoma in a Mouse Tumor Model
RESUMO
The goal of the current study was to determine if the antiangiogenic drug Avastin would improve the effectiveness of Photodynamic Therapy (PDT) in a xenograft model of Kaposi's sarcoma (KS). Human KS-Imm tumors transplanted in nude mice were treated with Photofrin-mediated PDT. Expression parameters of proangiogenic molecules were documented and the tumoricidal effectiveness of PDT combined with the VEGF inhibitor Avastin was determined. PDT induced increased expression of HIF-1α, VEGF, PGE2, TNF-α, and IL-1β within treated KS tumor tissue. Significant overexpression of KS cell derived human VEGF and to a lesser extent overexpression of host cell derived mouse VEGF were detected within treated tumors. Combining PDT with Avastin resulted in a significant increase in the long-term responsiveness of treated KS tumors when compared to individual treatments. These results demonstrate for the first time that Avastin can improve PDT treatment effectiveness and suggest that VEGF inhibitors may ameliorate the clinical efficacy of PDT.
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Weyergang Anette, Selbo Pål K., Berg Kristian, Sustained EKR inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy, Biochimica et Biophysica Acta (BBA) - General Subjects, 1830, 3, 2013. Crossref
-
Gallagher-Colombo Shannon M., Maas Amanda L., Yuan Min, Busch Theresa M., Photodynamic Therapy-Induced Angiogenic Signaling: Consequences and Solutions to Improve Therapeutic Response, Israel Journal of Chemistry, 52, 8-9, 2012. Crossref
-
Gomer Charles J., Ferrario Angela, Luna Marian, Rucker Natalie, Wong Sam, Photodynamic therapy: Combined modality approaches targeting the tumor microenvironment, Lasers in Surgery and Medicine, 38, 5, 2006. Crossref
-
Bozkulak Ozguncem, Wong Sam, Luna Marian, Ferrario Angela, Rucker Natalie, Gulsoy Murat, Gomer Charles J., Multiple Components of Photodynamic Therapy Can Phosphorylate Akt?, Photochemistry and Photobiology, 83, 5, 2007. Crossref
-
Kwitniewski Mateusz, Juzeniene Asta, Glosnicka Renata, Moan Johan, Immunotherapy: a way to improve the therapeutic outcome of photodynamic therapy?, Photochemical & Photobiological Sciences, 7, 9, 2008. Crossref
-
O’Connor Aisling E., Gallagher William M., Byrne Annette T., Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy, Photochemistry and Photobiology, 85, 5, 2009. Crossref
-
Weyergang Anette, Kaalhus Olav, Berg Kristian, Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478, Photochemical & Photobiological Sciences, 7, 9, 2008. Crossref
-
Bhuvaneswari Ramaswamy, Yuen Gan Yik, Chee Soo Khee, Olivo Malini, Hypericin-mediated photodynamic therapy in combination with Avastin (bevacizumab) improves tumor response by downregulating angiogenic proteins, Photochemical & Photobiological Sciences, 6, 12, 2007. Crossref
-
Postiglione Ilaria, Chiaviello Angela, Palumbo Giuseppe, Enhancing Photodynamyc Therapy Efficacy by Combination Therapy: Dated, Current and Oncoming Strategies, Cancers, 3, 2, 2011. Crossref
-
Jiang Feng, Zhang Xuepeng, Kalkanis Steven N., Zhang ZhengGang, Yang Hongyan, Katakowski Mark, Hong Xin, Zheng Xuguang, Zhu Zhenping, Chopp Michael, Combination Therapy with Antiangiogenic Treatment and Photodynamic Therapy for the Nude Mouse Bearing U87 Glioblastoma, Photochemistry and Photobiology, 2007. Crossref
-
Bhuvaneswari Ramaswamy, Gan Yik Yuen, Soo Khee Chee, Olivo Malini, The effect of photodynamic therapy on tumor angiogenesis, Cellular and Molecular Life Sciences, 66, 14, 2009. Crossref
-
Olivo Malini, Bhuvaneswari Ramaswamy, Lucky Sasidharan Swarnalatha, Dendukuri Nagamani, Soo-Ping Thong Patricia, Targeted Therapy of Cancer Using Photodynamic Therapy in Combination with Multi-faceted Anti-Tumor Modalities, Pharmaceuticals, 3, 5, 2010. Crossref
-
Bhuvaneswari Ramaswamy, Thong Patricia S. P., Gan Yik-Yuen, Soo Khee, Olivo Malini, Evaluation of hypericin-mediated photodynamic therapy in combination with angiogenesis inhibitor bevacizumab using in vivo fluorescence confocal endomicroscopy, Journal of Biomedical Optics, 15, 1, 2010. Crossref
-
Serra Arménio, Pineiro Marta, Pereira Nelson, Rocha Gonsalves António, Laranjo Mafalda, Abrantes Margarida, Botelho Filomena, A look at clinical applications and developments of photodynamic therapy, Oncology Reviews, 2, 4, 2008. Crossref
-
Snell Sara B., Foster Thomas H., Haidaris Constantine G., Miconazole Induces Fungistasis and Increases Killing of Candida albicans Subjected to Photodynamic Therapy†, Photochemistry and Photobiology, 88, 3, 2012. Crossref
-
Kawczyk-Krupka A., Sieroń-Stołtny K., Latos W., Czuba Z.P., Kwiatek B., Potempa M., Wasilewska K., Król W., Stanek A., ALA-induced photodynamic effect on vitality, apoptosis, and secretion of vascular endothelial growth factor (VEGF) by colon cancer cells in normoxic environment in vitro, Photodiagnosis and Photodynamic Therapy, 13, 2016. Crossref
-
Agostinis Patrizia, Berg Kristian, Cengel Keith A., Foster Thomas H., Girotti Albert W., Gollnick Sandra O., Hahn Stephen M., Hamblin Michael R., Juzeniene Asta, Kessel David, Korbelik Mladen, Moan Johan, Mroz Pawel, Nowis Dominika, Piette Jacques, Wilson Brian C., Golab Jakub, Photodynamic therapy of cancer: An update, CA: A Cancer Journal for Clinicians, 61, 4, 2011. Crossref
-
Marchal Sophie, Dolivet Gilles, Lassalle Henri-Pierre, Guillemin François, Bezdetnaya Lina, Targeted photodynamic therapy in head and neck squamous cell carcinoma: heading into the future, Lasers in Medical Science, 30, 9, 2015. Crossref
-
Weiss Andrea, den Bergh Hubert van, Griffioen Arjan W., Nowak-Sliwinska Patrycja, Angiogenesis inhibition for the improvement of photodynamic therapy: The revival of a promising idea, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1826, 1, 2012. Crossref
-
Ferrario Angela, Luna Marian, Rucker Natalie, Wong Sam, Gomer Charles J., Pro-apoptotic and anti-inflammatory properties of the green tea constituent epigallocatechin gallate increase photodynamic therapy responsiveness, Lasers in Surgery and Medicine, 43, 7, 2011. Crossref
-
Selbo Pål Kristian, Bostad Monica, Olsen Cathrine Elisabeth, Edwards Victoria Tudor, Høgset Anders, Weyergang Anette, Berg Kristian, Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics, Photochemical & Photobiological Sciences, 14, 8, 2015. Crossref
-
Korbelik Mladen, Hamblin Michael R., The impact of macrophage-cancer cell interaction on the efficacy of photodynamic therapy, Photochemical & Photobiological Sciences, 14, 8, 2015. Crossref
-
Ferrario Angela, Gomer Charles J., Targeting the 90kDa heat shock protein improves photodynamic therapy, Cancer Letters, 289, 2, 2010. Crossref
-
Yachimski Patrick, Mino-Kenudson Mari, Sherwood Margaret E., Puricelli William P., Nishioka Norman S., Lauwers Gregory Y., Cyclooxygenase-2 expression in esophageal epithelium before and after photodynamic therapy for Barrett’s esophagus with high-grade dysplasia or intramucosal carcinoma, Virchows Archiv, 459, 6, 2011. Crossref
-
Dai Lu, Bratoeva Momka, Toole Bryan P., Qin Zhiqiang, Parsons Chris, KSHV activation of VEGF secretion and invasion for endothelial cells is mediated through viral upregulation of emmprin-induced signal transduction, International Journal of Cancer, 131, 4, 2012. Crossref
-
Broekgaarden Mans, Weijer Ruud, van Gulik Thomas M., Hamblin Michael R., Heger Michal, Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies, Cancer and Metastasis Reviews, 34, 4, 2015. Crossref
-
Laquer Vivian, Hoang Van, Nguyen Amy, Kelly Kristen M., Angiogenesis in cutaneous disease: Part II, Journal of the American Academy of Dermatology, 61, 6, 2009. Crossref
-
Friedberg Joseph S., Photodynamic Therapy as an Innovative Treatment for Malignant Pleural Mesothelioma, Seminars in Thoracic and Cardiovascular Surgery, 21, 2, 2009. Crossref
-
Wagner Andrej, Mayr Christian, Bach Doris, Illig Romana, Plaetzer Kristjan, Berr Frieder, Pichler Martin, Neureiter Daniel, Kiesslich Tobias, MicroRNAs Associated with the Efficacy of Photodynamic Therapy in Biliary Tract Cancer Cell Lines, International Journal of Molecular Sciences, 15, 11, 2014. Crossref
-
Dąbrowski Janusz M., Pucelik Barbara, Regiel-Futyra Anna, Brindell Małgorzata, Mazuryk Olga, Kyzioł Agnieszka, Stochel Grażyna, Macyk Wojciech, Arnaut Luis G., Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers, Coordination Chemistry Reviews, 325, 2016. Crossref
-
Obaid Girgis, Broekgaarden Mans, Bulin Anne-Laure, Huang Huang-Chiao, Kuriakose Jerrin, Liu Joyce, Hasan Tayyaba, Photonanomedicine: a convergence of photodynamic therapy and nanotechnology, Nanoscale, 8, 25, 2016. Crossref
-
Martín Liberal Juan, Lagares-Tena Laura, Sáinz-Jaspeado Miguel, Mateo-Lozano Silvia, García del Muro Xavier, Tirado Oscar M., Targeted Therapies in Sarcomas: Challenging the Challenge, Sarcoma, 2012, 2012. Crossref
-
Broekgaarden Mans, Weijer Ruud, Krekorian Massis, van den IJssel Bas, Kos Milan, Alles Lindy K., van Wijk Albert C., Bikadi Zsolt, Hazai Eszter, van Gulik Thomas M., Heger Michal, Inhibition of hypoxia-inducible factor 1 with acriflavine sensitizes hypoxic tumor cells to photodynamic therapy with zinc phthalocyanine-encapsulating cationic liposomes, Nano Research, 9, 6, 2016. Crossref
-
Abbaraju Prasanna Lakshmi, Yang Yannan, Yu Meihua, Fu Jianye, Xu Chun, Yu Chengzhong, Core-Shell-structured Dendritic Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Antibody Delivery, Chemistry - An Asian Journal, 12, 13, 2017. Crossref
-
Zhao Hongyou, Yin Rong, Wang Ying, Lee Yuan-Hao, Luo Ting, Zhang Jiaying, Qiu Haixia, Ambrose Stephen, Wang Lijie, Ren Jie, Yao Jie, Chen Defu, Wang Yucheng, Liang Zhipin, Zhen Jie, Wu Sumin, Ye Zulin, Zeng Jing, Huang Naiyan, Gu Ying, Modulating mitochondrial morphology enhances antitumor effect of 5-ALA-mediated photodynamic therapy both in vitro and in vivo, Journal of Photochemistry and Photobiology B: Biology, 176, 2017. Crossref
-
Gallagher‐Colombo Shannon M., Finlay Jarod C., Busch Theresa M., Tumor Microenvironment as a Determinant of Photodynamic Therapy Resistance, in Resistance to Photodynamic Therapy in Cancer, 5, 2015. Crossref
-
Korbelik Mladen, Tumor-Localized Insult Delivered by Photodynamic Therapy and the Breakdown of Tumor Immunotolerance, in Tumor Ablation, 2013. Crossref
-
Della Pietra Emilia, Rapozzi Valentina, Photodynamic Therapy and Nitric Oxide, in Nitric Oxide and Cancer: Pathogenesis and Therapy, 2015. Crossref
-
Ferrario Angela, Gomer Charles J., Targeting the Tumor Microenvironment Using Photodynamic Therapy Combined with Inhibitors of Cyclooxygenase-2 or Vascular Endothelial Growth Factor, in Photodynamic Therapy, 635, 2010. Crossref
-
Du Kevin L., Finlay Jarod C., Zhu Timothy C., Busch Theresa M., Oxidative Stress and Photodynamic Therapy for Prostate Cancer, in Oxidative Stress in Cancer Biology and Therapy, 2012. Crossref
-
Trunov Alexander, Belikov Alexander, Development of Architectural Realizations of Phototherapy Computer's Systems for Prevention and Treatment, 2019 10th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications (IDAACS), 2019. Crossref
-
Luna Marian, Ferrario Angela, Rucker Natalie, Balouzian Emma, Wong Sam, Mansfield Sophie, Gomer Charles J., Cellular Targets and Molecular Responses Associated with Photodynamic Therapy, in Resistance to Photodynamic Therapy in Cancer, 5, 2015. Crossref
-
Weijer Ruud, Broekgaarden Mans, Krekorian Massis, Alles Lindy K., van Wijk Albert C., Mackaaij Claire, Verheij Joanne, van der Wal Allard C., van Gulik Thomas M., Storm Gert, Heger Michal, Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy, Oncotarget, 7, 3, 2016. Crossref
-
Majerník Martin, Jendželovský Rastislav, Fedoročko Peter, Potentiality, Limitations, and Consequences of Different Experimental Models to Improve Photodynamic Therapy for Cancer Treatment in Relation to Antiangiogenic Mechanism, Cancers, 12, 8, 2020. Crossref
-
Gunaydin Gurcan, Gedik M. Emre, Ayan Seylan, Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status, Frontiers in Chemistry, 9, 2021. Crossref
-
Triesscheijn Martijn, Baas Paul, Schellens Jan H. M., Stewart Fiona A., Photodynamic Therapy in Oncology, The Oncologist, 11, 9, 2006. Crossref
-
Griffioen Arjan W., Weiss Andrea, Berndsen Robert H., Abdul U. Kulsoom, te Winkel Marije T., Nowak-Sliwinska Patrycja, The emerging quest for the optimal angiostatic combination therapy, Biochemical Society Transactions, 42, 6, 2014. Crossref
-
Anand Sanjay, Wilson Clara, Hasan Tayyaba, Maytin Edward V., Vitamin D3 Enhances the Apoptotic Response of Epithelial Tumors to Aminolevulinate-Based Photodynamic Therapy, Cancer Research, 71, 18, 2011. Crossref
-
Kosharskyy Boleslav, Solban Nicolas, Chang Sung K., Rizvi Imran, Chang Yuchiao, Hasan Tayyaba, A Mechanism-Based Combination Therapy Reduces Local Tumor Growth and Metastasis in an Orthotopic Model of Prostate Cancer, Cancer Research, 66, 22, 2006. Crossref
-
Ma Shuai, Wang Fang, Dong Jiawei, Wang Nan, Tao Shengzhong, Du Jianyang, Hu Shaoshan, Inhibition of hypoxia-inducible factor 1 by acriflavine renders glioblastoma sensitive for photodynamic therapy, Journal of Photochemistry and Photobiology B: Biology, 234, 2022. Crossref