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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Avastin Enhances Photodynamic Therapy Treatment of Kaposi's Sarcoma in a Mouse Tumor Model

Volume 25, Edição 1-2, 2006, pp. 251-260
DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i1-2.160
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RESUMO

The goal of the current study was to determine if the antiangiogenic drug Avastin would improve the effectiveness of Photodynamic Therapy (PDT) in a xenograft model of Kaposi's sarcoma (KS). Human KS-Imm tumors transplanted in nude mice were treated with Photofrin-mediated PDT. Expression parameters of proangiogenic molecules were documented and the tumoricidal effectiveness of PDT combined with the VEGF inhibitor Avastin was determined. PDT induced increased expression of HIF-1α, VEGF, PGE2, TNF-α, and IL-1β within treated KS tumor tissue. Significant overexpression of KS cell derived human VEGF and to a lesser extent overexpression of host cell derived mouse VEGF were detected within treated tumors. Combining PDT with Avastin resulted in a significant increase in the long-term responsiveness of treated KS tumors when compared to individual treatments. These results demonstrate for the first time that Avastin can improve PDT treatment effectiveness and suggest that VEGF inhibitors may ameliorate the clinical efficacy of PDT.

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