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KLF4 in Ovarian Cancer

Volume 7, Edição 1-2, 2016, pp. 119-126
DOI: 10.1615/ForumImmunDisTher.2016017273
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RESUMO

The Kruppel-like factor 4 (KLF4) transcriptional factor functions as a tumor suppressor or oncogene in different human cancers. Ovarian cancer is one of the most aggressive malignancies in women. In this review, we discuss the role of KLF4 and the KLF4 regulatory network in ovarian cancer. KLF4 expression inhibits ovarian cancer cell proliferation, migration, invasion, and metastasis. KLF4 inhibits the epithelial-to-mesenchymal transition by directly binding to the promoter of E-cadherin in ovarian cancer cells. Moreover, KLF4 inhibits the cancer stem cell phenotype in ovarian cancer. KLF4 not only regulates microRNA expression but is also targeted by microRNAs. It is a potential biomarker for prognosis and drug targeting in ovarian cancer and may contribute to ovarian cancer metastasis and chemoresistance through a complex gene regulatory network.

Palavras-chave: EMT, KLF4, ovarian cancer
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