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Immune Complex Analysis in Active Lyme Disease

Volume 7, Edição 3-4, 2016, pp. 213-224
DOI: 10.1615/ForumImmunDisTher.2017019621
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RESUMO

Lyme disease (LD) is a growing infectious disease. Assays that can detect active infection early are needed to allow appropriate antibiotic therapy to begin when there is the best chance for a cure. The most frequently used assays are those based on antibodies to Borrelia burgdorferi or its variants, the causative agent of LD. However, an antibody test at a single time point only measures exposure, not necessarily an active infection. In contrast, antibodies that are bound to a target antigen in a circulating immune complex form do indicate active infection. Here, we present data supporting the use of such assays in LD.

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