Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
Accessory Molecule and Costimulation Requirements for CD4 T Cell Response
RESUMO
T cell activation is brought about by recognition of peptide/MHC complexes on an antigen-presenting cell (APC) by the T cell receptor (TCR). However, in general this appears to be insufficient for the full development of T cell responses and therefore additional signals are required, provided by ligation of counter-receptors on the T cell by APC accessory molecules. Although many studies have suggested that B7 molecules (CD80/CD86) binding to CD28 induce this second signal, it is now evident that any one of a number of molecules may provide accessory function and that efficient response is only generated following multiple interactions. It has also become clear that T cells exist in varying states of activation or differentiation, and that requirements for accessory molecules and costimuli are not always equivalent. This review covers much of the recent data regarding accessory molecule regulation of T cell responses. A modified version of the two signal model is presented, suggesting that the major function of accessory molecules during the initial stages of activation is to augment the ability to signal through the TCR, and that the primary role of costimulatory signals is to allow IL-2 secretion and growth. The requirement for multiple accessory molecule interactions is discussed in relation to activation of naive T cells and how such interactions are less critical at the memory and effector stages. Finally, this new information is related to how T cells interact with varying APC and how these interactions may modulate T cell response.
-
Bros , Haas , Moll , Grabbe , RhoA as a Key Regulator of Innate and Adaptive Immunity, Cells, 8, 7, 2019. Crossref
-
Bhat Jaydeep, Kabelitz Dieter, An introduction to immunology and epigenetics, in Epigenetics of the Immune System, 2020. Crossref
-
de Carvalho José Tarcísio Giffoni, Da Silva Baldivia Debora, de Castro David Tsuyoshi Hiramatsu, dos Santos Helder Freitas, dos Santos Cintia Miranda, Oliveira Alex Santos, Alfredo Tamaeh Monteiro, Vilharva Kellen Natalice, de Picoli Souza Kely, dos Santos Edson Lucas, The immunoregulatory function of polyphenols: implications in cancer immunity, The Journal of Nutritional Biochemistry, 85, 2020. Crossref
-
Ma Chi, Hoffmann FuKun W., Marciel Michael P., Page Kathleen E., Williams-Aduja Melodie A., Akana Ellis N.L., Gojanovich Greg S., Gerschenson Mariana, Urschitz Johann, Moisyadi Stefan, Khadka Vedbar S., Rozovsky Sharon, Deng Youping, Horgen F. David, Hoffmann Peter R., Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation, Molecular Metabolism, 47, 2021. Crossref
-
Nagahata Taichi, Tsujino Yoshio, Takayama Eiji, Hikasa Haruka, Satoh Ayano, Evaluation of skin sensitization based on interleukin‑2 promoter activation in Jurkat cells, Biomedical Reports, 16, 1, 2021. Crossref
-
Londregan Jennifer, Maslanka Jeffrey, Goldman Naomi, Somerville John, Riggs James E., IgD ligation allows peritoneal cavity B cell proliferation, Immunobiology, 227, 2, 2022. Crossref
-
Greisen Stinne R., Aspari Maithri, Deleuran Bent, Co-Inhibitory Molecules – Their Role in Health and Autoimmunity; Highlighted by Immune Related Adverse Events, Frontiers in Immunology, 13, 2022. Crossref
-
Ma Chi, Hoffmann Peter R., Selenoproteins as regulators of T cell proliferation, differentiation, and metabolism, Seminars in Cell & Developmental Biology, 115, 2021. Crossref