Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
CD5 as a Target for Immune-Based Therapies
RESUMO
CD5 was one of the first surface receptors described for mouse and human T lymphocytes. Since then, it has been found to be highly expressed by regulatory T cells and a subpopulation of regulatory B cells, to be physically associated with the T- and B-cell antigen receptors, to negatively modulate TCR- and BCR-mediated signals, and to bind certain pathogen-associated molecular patterns. These findings position CD5 as an attractive target for developing immunotherapies aimed at either boosting or dampening ongoing immune responses. Here the available data on the function of CD5 and its involvement in the regulation of immune responses in health and disease are reviewed, as well as the evidence for and future challenges in developing therapeutic strategies aimed at targeting CD5 for autoimmune diseases, cancer, and infections.
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Potrony Miriam, Carreras Esther, Aranda Fernando, Zimmer Lisa, Puig-Butille Joan-Anton, Tell-Martí Gemma, Armiger Noelia, Sucker Antje, Giménez-Xavier Pol, Martínez-Florensa Mario, Carrera Cristina, Malvehy Josep, Schadendorf Dirk, Puig Susana, Lozano Francisco, Inherited functional variants of the lymphocyte receptor CD5 influence melanoma survival, International Journal of Cancer, 139, 6, 2016. Crossref
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Vasquez Marcos, Simões Inês, Consuegra-Fernández Marta, Aranda Fernando, Lozano Francisco, Berraondo Pedro, Exploiting scavenger receptors in cancer immunotherapy: Lessons from CD5 and SR-B1, European Journal of Immunology, 47, 7, 2017. Crossref
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Nagasawa Maho, Germar Kristine, Blom Bianca, Spits Hergen, Human CD5+ Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34+ Progenitor Cells Is Regulated by Id2, Frontiers in Immunology, 8, 2017. Crossref
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Consuegra-Fernández Marta, Lin Feng, Fox David A., Lozano Francisco, Clinical and experimental evidence for targeting CD6 in immune-based disorders, Autoimmunity Reviews, 17, 5, 2018. Crossref
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Pitoiset Fabien, Cassard Lydie, El Soufi Karim, Boselli Lisa, Grivel Jonathan, Roux Alexandra, Klatzmann David, Chaput Nathalie, Rosenzwajg Michelle, Deep phenotyping of immune cell populations by optimized and standardized flow cytometry analyses, Cytometry Part A, 93, 8, 2018. Crossref
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Freitas Claudia, Johnson Deborah, Weber K., T Cell Calcium Signaling Regulation by the Co-Receptor CD5, International Journal of Molecular Sciences, 19, 5, 2018. Crossref
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Simões Inês T., Aranda Fernando, Carreras Esther, Andrés Maria Velasco-de, Casadó-Llombart Sergi, Martinez Vanesa G., Lozano Francisco, Immunomodulatory effects of soluble CD5 on experimental tumor models, Oncotarget, 8, 64, 2017. Crossref
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Casadó-Llombart Sergi, Velasco-de Andrés María, Català Cristina, Leyton-Pereira Alejandra, Lozano Francisco, Bosch Elena, Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6, International Journal of Molecular Sciences, 22, 10, 2021. Crossref
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Jaseb Kaveh, Purrahman Daryush, Shahrabi Saeid, Ghanavat Majid, Rezaeean Hadi, Saki Najmaldin, Prognostic significance of aberrant CD5 expression in B-cell leukemia, Oncology Reviews, 13, 1, 2019. Crossref
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Wadenpohl Josefine, Seyfarth Julia, Hehenkamp Paul, Hoffmann Maximilian, Kummer Sebastian, Reinauer Christina, Döing Carsten, Förtsch Katharina, Mayatepek Ertan, Meissner Thomas, Jacobsen Marc, CD5‐expressing CD8 + T‐cell subsets differ between children with type 1 diabetes and controls , Immunology & Cell Biology, 99, 10, 2021. Crossref
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Whitley Kiara V., Freitas Claudia M. Tellez, Moreno Carlos, Haynie Christopher, Bennett Joshua, Hancock John C., Cox Tyler D., Pickett Brett E., Weber K. Scott, CD5 Deficiency Alters Helper T Cell Metabolic Function and Shifts the Systemic Metabolome, Biomedicines, 10, 3, 2022. Crossref
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Halperin Saar T., ’t Hart Bert A., Luchicchi Antonio, Schenk Geert J., The Forgotten Brother: The Innate-like B1 Cell in Multiple Sclerosis, Biomedicines, 10, 3, 2022. Crossref
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Lu Ting-Xun, Wu Shuang, Zhou Xin-Yi, Zhang Ying, Hong Ting-Ting, Cai Dong-Yan, Hua Hai-Ying, Qi Xiao-Wei, Wu Xiao-Hong, CD5+MYC+ predicts worse prognosis in diffuse large B-cell lymphoma, Experimental and Molecular Pathology, 112, 2020. Crossref
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Casadó-Llombart Sergi, Gheitasi Hoda, Ariño Silvia, Consuegra-Fernández Marta, Armiger-Borràs Noelia, Kostov Belchin, Ramos-Casals Manuel, Brito-Zerón Pilar, Lozano Francisco, Gene Variation at Immunomodulatory and Cell Adhesion Molecules Loci Impacts Primary Sjögren's Syndrome, Frontiers in Medicine, 9, 2022. Crossref
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Velasco-de Andrés María, Català Cristina, Casadó-Llombart Sergi, Martínez-Florensa Mario, Simões Inês, García-Luna Joaquín, Mourglia-Ettlin Gustavo, Zaragoza Óscar, Carreras Esther, Lozano Francisco, The Lymphocytic Scavenger Receptor CD5 Shows Therapeutic Potential in Mouse Models of Fungal Infection, Antimicrobial Agents and Chemotherapy, 65, 1, 2020. Crossref
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Sui Songnan, Li Zhiyan, Tan Jiaxiong, Wang Liang, Luo Gengxin, Zeng Chengwu, Luo Oscar Junhong, Chen Cunte, Li Yangqiu, Liu Bin, Low Expression of CD5 and CD6 Is Associated with Poor Overall Survival for Patients with T-Cell Malignancies, Journal of Oncology, 2022, 2022. Crossref
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Casadó-Llombart Sergi, Velasco-de Andrés María, Català Cristina, Leyton-Pereira Alejandra, Gutiérrez-Cózar Rebeca, Suárez Belén, Armiger Noelia, Carreras Esther, Esteller Miriam, Ricart Elena, Ordás Ingrid, Gisbert Javier P., Chaparro María, Esteve María, Márquez Lucía, Busquets David, Iglesias Eva, García-Planella Esther, Martín-Arranz María Dolores, Lohmann Juliane, Ayata C. Korcan, Niess Jan Hendrik, Engel Pablo, Panés Julián, Salas Azucena, Domènech Eugeni, Lozano Francisco, Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease, Frontiers in Immunology, 13, 2022. Crossref
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Lu Mingmin, Lee Youngsub, Lillehoj Hyun S., Evolution of developmental and comparative immunology in poultry: The regulators and the regulated, Developmental & Comparative Immunology, 138, 2023. Crossref