Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
Strategies to enhance NK cell function for the treatment of tumors and infections
RESUMO
Natural killer (NK) cells are innate immune cells equipped with the ability to rapidly kill stressed cells that are neoplastic or virally infected. These cells are especially important in settings where these stressed cells downregulate MHC class I molecules and evade recognition by cytotoxic T cells. However, the activity of NK cells alone is often suboptimal to fully control tumor growth or to clear viral infections. Thus, the enhancement of NK cell function is necessary to fully harness their antitumor or antiviral potential. In this review, we discuss how NK cell function can be augmented by the modulation of signal transduction pathways, by the manipulation of inhibitory/activating receptors on NK cells, and by cytokine-induced activation. We also discuss how some of these strategies are currently impacting NK cells in the treatment of cancer and infections.
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Naeimi Kararoudi Meisam, Tullius Brian P., Chakravarti Nitin, Pomeroy Emily J., Moriarity Branden S., Beland Kathie, Colamartino Aurelien B.L., Haddad Elie, Chu Yaya, Cairo Mitchell S., Lee Dean A., Genetic and epigenetic modification of human primary NK cells for enhanced antitumor activity, Seminars in Hematology, 57, 4, 2020. Crossref
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Senekal Noma Susan, Mahasa Khaphetsi Joseph, Eladdadi Amina, de Pillis Lisette, Ouifki Rachid, Natural Killer Cells Recruitment in Oncolytic Virotherapy: A Mathematical Model, Bulletin of Mathematical Biology, 83, 7, 2021. Crossref
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Long Shiqi, Gu Yangzhuo, An Yuanyuan, Lin Xiaojin, Chen Xiaoqing, Wang Xianyao, Liao Chunxiang, Ouyang Weiwei, Wang Nianxue, He Zhixu, Zhao Xing, Reovirus enhances cytotoxicity of natural killer cells against colorectal cancer via TLR3 pathway, Journal of Translational Medicine, 19, 1, 2021. Crossref
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Long Shiqi, Gu Yangzhuo, An Yuanyuan, Lin Xiaojin, Chen Xiaoqing, Wang Xianyao, Liao Chunxiang, Ouyang Weiwei, Wang Nianxue, He Zhixu, Zhao Xing, Reovirus Enhances Cytotoxicity of Natural Killer Cells Against Colorectal Cancer via TLR3 Pathway, SSRN Electronic Journal , 2020. Crossref
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