Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
Fungal Capsular Polysaccharide and T-Cell Suppression: The Hidden Nature of Poor Immunogenicity
RESUMO
Many capsular polysaccharide antigens are generally considered to be classic T-cell independent antigens that stimulate humoral response. This response is poor and short lived due to the absence of T-cell involvement. Recent emerging evidence suggests that fungal capsular polysaccharides may negatively affect T-cell response. This effect is indirectly mediated by antigen-presenting cells that sense microbial polysaccharides and manage T-cell response. This review will revisit the role of the cryptococcal capsular polysaccharide as a nonconventional regulator of natural and adaptive immune response, revealing the hidden nature of its poor immunogenicity and novel opportunities for the biomedical exploitation of this nontoxic compound.
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Khan Masood Alam, Aljarbou Ahmed, Khan Arif, Owais Mohammad, Immune stimulating and therapeutic potential of tuftsin-incorporated nystatin liposomes against Cryptococcus neoformans in leukopenic BALB/C mice, FEMS Immunology & Medical Microbiology, 66, 1, 2012. Crossref
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Guimarães Allan Jefferson, Frases Susana, Cordero Radamés J. B., Nimrichter Leonardo, Casadevall Arturo, Nosanchuk Joshua D., Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo, Cellular Microbiology, 12, 6, 2010. Crossref
-
Gómez-López Alicia, Zaragoza Oscar, Rodríguez-Tudela Juan Luis, Cuenca-Estrella Manuel, Pharmacotherapy of yeast infections, Expert Opinion on Pharmacotherapy, 9, 16, 2008. Crossref
-
Xia Rong, Hu Zhide, Sun Yi, Chen Sunxiao, Gu Mingli, Zhou Ye, Han Zhijun, Zhong Renqian, Deng Anmei, Wen Hai, Overexpression of β-Arrestin 2 in Peripheral Blood Mononuclear Cells of Patients With Cryptococcal Meningitis, Journal of Interferon & Cytokine Research, 30, 3, 2010. Crossref
-
Nakouzi Antonio, Zhang Tong, Oscarson Stefan, Casadevall Arturo, The common Cryptococcus neoformans glucuronoxylomannan M2 motif elicits non-protective antibodies, Vaccine, 27, 27, 2009. Crossref
-
Wolf Julie M., Rivera Johanna, Casadevall Arturo, Serum albumin disrupts Cryptococcus neoformans and Bacillus anthracis extracellular vesicles, Cellular Microbiology, 14, 5, 2012. Crossref
-
Oliveira Débora L., Nimrichter Leonardo, Miranda Kildare, Frases Susana, Faull Kym F., Casadevall Arturo, Rodrigues Marcio L., Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannan, Fungal Genetics and Biology, 46, 12, 2009. Crossref
-
Mora Delio José, Fortunato Laila Rigolin, Andrade-Silva Leonardo Eurípedes, Ferreira-Paim Kennio, Rocha Ivonete Helena, Vasconcelos Rakel Rocha, Silva-Teixeira David Nascimento, Nascentes Gabriel Antonio Nogueira, Silva-Vergara Mario León, May Robin Charles, Cytokine Profiles at Admission Can Be Related to Outcome in AIDS Patients with Cryptococcal Meningitis, PLOS ONE, 10, 3, 2015. Crossref
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Zaragoza Oscar, García-Rodas Rocío, Nosanchuk Joshua D., Cuenca-Estrella Manuel, Rodríguez-Tudela Juan Luis, Casadevall Arturo, Mitchell Aaron P., Fungal Cell Gigantism during Mammalian Infection, PLoS Pathogens, 6, 6, 2010. Crossref
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Liedke Susie Coutinho, Miranda Daniel Zamith, Gomes Kamilla Xavier, Gonçalves Jorge Luis S., Frases Susana, Nosanchuk Joshua D., Rodrigues Marcio L., Nimrichter Leonardo, Peralta José Mauro, Guimarães Allan J., Characterization of the antifungal functions of a WGA-Fc (IgG2a) fusion protein binding to cell wall chitin oligomers, Scientific Reports, 7, 1, 2017. Crossref
-
Jiang Ying-Kui, Wu Ji-Qin, Zhao Hua-Zhen, Wang Xuan, Wang Rui-Ying, Zhou Ling-Hong, Yip Ching-Wan, Huang Li-Ping, Cheng Jia-Hui, Chen Ya-Hong, Li Hua, Zhu Li-Ping, Weng Xin-Hua, Genetic influence of Toll-like receptors on non-HIV cryptococcal meningitis: An observational cohort study, EBioMedicine, 37, 2018. Crossref
-
Gagliardi Maria Cristina, Teloni Raffaela, Mariotti Sabrina, Bromuro Carla, Chiani Paola, Romagnoli Giulia, Giannoni Federico, Torosantucci Antonella, Nisini Roberto, Endogenous PGE2 promotes the induction of human Th17 responses by fungal β-glucan, Journal of Leukocyte Biology, 88, 5, 2010. Crossref
-
Hart K.A., Flaminio M.J.B.F., LeRoy B.E., Williams C.O., Dietrich U.M., Barton M.H., Successful Resolution of Cryptococcal Meningitis and Optic Neuritis in an Adult Horse with Oral Fluconazole, Journal of Veterinary Internal Medicine, 22, 6, 2008. Crossref
-
Khan Muhammad Saeed, Zhang Xuewu, You Lijun, Fu Xiong, Abbasi Arshad Mehmood, Structure and Bioactivities of Fungal Polysaccharides, in Polysaccharides, 2014. Crossref
-
Casadevall Arturo, Dadachova Ekaterina, Pirofski Liise-Anne, Vaccines and Antibody Therapies from Cryptococcus neoformans to Melanoma, in Cryptococcus, 2014. Crossref
-
Perfect John R., Casadevall Arturo, The History of Cryptococcus and Cryptococcosis, in Cryptococcus, 2014. Crossref
-
Fonseca Fernanda L., Frases Susana, Casadevall Arturo, Fischman-Gompertz Olga, Nimrichter Leonardo, Rodrigues Marcio L., Structural and functional properties of the Trichosporon asahii glucuronoxylomannan, Fungal Genetics and Biology, 46, 6-7, 2009. Crossref
-
Piccioni M, Monari C, Bevilacqua S, Perito S, Bistoni F, Kozel T R, Vecchiarelli A, A critical role for FcgammaRIIB in up-regulation of Fas ligand induced by a microbial polysaccharide, Clinical and Experimental Immunology, 165, 2, 2011. Crossref
-
Fonseca Fernanda L., Nohara Lilian L., Cordero Radames J. B., Frases Susana, Casadevall Arturo, Almeida Igor C., Nimrichter Leonardo, Rodrigues Marcio L., Immunomodulatory Effects of Serotype B Glucuronoxylomannan from Cryptococcus gattii Correlate with Polysaccharide Diameter , Infection and Immunity, 78, 9, 2010. Crossref
-
Romani Luigina, Immunity to fungal infections, Nature Reviews Immunology, 11, 4, 2011. Crossref
-
Lupo P., Chang Y. C., Kelsall B. L., Farber J. M., Pietrella D., Vecchiarelli A., Leon F., Kwon-Chung K. J., The Presence of Capsule in Cryptococcus neoformans Influences the Gene Expression Profile in Dendritic Cells during Interaction with the Fungus , Infection and Immunity, 76, 4, 2008. Crossref
-
Summers Katie Lynn, Arfken Ann M., The Gut Mycobiome and Animal Health, in Gut Microbiota, Immunity, and Health in Production Animals, 4, 2022. Crossref
-
Piccioni M., Monari C., Kenno S., Pericolini E., Gabrielli E., Pietrella D., Perito S., Bistoni F., Kozel T. R., Vecchiarelli A., Deepe G. S., A Purified Capsular Polysaccharide Markedly Inhibits Inflammatory Response during Endotoxic Shock, Infection and Immunity, 81, 1, 2013. Crossref