Inscrição na biblioteca: Guest
Critical Reviews™ in Oncogenesis

Publicou 4 edições por ano

ISSN Imprimir: 0893-9675

ISSN On-line: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Steel Factor and c-kit Protooncogene: Genetic Lessons in Signal Transduction

Volume 5, Edição 2-3, 1994, pp. 141-168
DOI: 10.1615/CritRevOncog.v5.i2-3.30
Get accessGet access

RESUMO

Despite extensive research on the molecular mechanisms of signal transduction by growth factors and their oncogenic receptor tyrosine kinases, the physiological relevance of these pathways, especially in mammals, remains largely unknown. A unique exception is the Steel factor (SLF) and its c-kit-encoded receptor, because many natural germ line mutations of both the ligand and the receptor exist in mice. The protooncogene c-kit encodes a cell surface receptor that belongs to the immunoglobulin gene family and carries an intrinsic tyrosine kinase activity in its cytoplasmic portion. The precursor of the Kit ligand, SLF, is also a transmembrane protein that exists as a soluble factor as well as a cell surface protein. The interaction of Kit with SLF leads to receptor dimerization, kinase activation, and tyrosine phosphorylation of cytoplasmic proteins that contain Src homology 2 motifs. Various mutations in Kit and SLF result in a defective signaling pathway and underly the complex phenotypes of W and Sl mice, respectively. The early development of at least four cell lineages is affected. These are erythrocytes, melanocytes, germ cells, and mast cells. Correlation between the behavior of these lineages and specific mutations uncovered interesting physiological aspects of the mechanism of signal transduction by a polypeptide growth factor. These include the different degrees of severity of affected lineages, indications for distinct functions during early embryonic development and at late phases, the significance of synergy between a growth factor and lymphokines, the interaction between mutant and wild-type proteins in heterozygous animals, and the possibility that a surface-anchored ligand may act differently than a soluble factor. Predictably, the lessons learned with Kit and Sl mice will be widely relevant to other pairs of ligands and receptors that control the function of different cell lineages and physiological processes.

CITADO POR
  1. Mojica W D, Saxena R, Starostik P, Cheney R T, CD117+ small cell lung cancer lacks the asp 816val point mutation in exon 17, Histopathology, 47, 5, 2005. Crossref

  2. Rupp Brigitte, Löhning Max, Werenskiold Anne Katrin, Reversible expression of tryptases in continuous L138.8A mast cells, European Journal of Immunology, 30, 10, 2000. Crossref

  3. Bennett Dorothy C., Trayner Ian D., Piao Xianhua, Easty David J, Klüppel Michael, Alexander Warren S., Wagner Erwin F., Bernstein Alan, recessive spotting: a linked locus that interacts withW/Kitbut is not allelic, Genes to Cells, 3, 4, 1998. Crossref

  4. Fesus L., Zsolnai A., Komlosi I., Influence of porcine coat colour genotypes on haematological parameters, piglet birth weight and body weight gain until weaning, Journal of Animal Breeding and Genetics, 122, 2, 2005. Crossref

  5. Yamaguchi Yasuo, Okabe Kazutoshi, Matsumura Fujio, Akizuki Eiji, Matsuda Teishi, Ohshiro Hajime, Liang Jian, Ishihara Kojiroh, Mori Katsutaka, Ogawa Michio, Expression of the c-kit proto-oncogene in rat hepatic allografts during acute rejection, Hepatology, 29, 1, 1999. Crossref

  6. Dibb Nick J., Dilworth Stephen M., Mol Clifford D., Switching on kinases: oncogenic activation of BRAF and the PDGFR family, Nature Reviews Cancer, 4, 9, 2004. Crossref

  7. Greisser Johannes, Doebbeling Udo, Roos Malgorzata, Mueller Beatrix, Schmid Mirka, Burg Gunter, Kadin Marshall E., Kempf Werner, Apoptosis in CD30-positive lymphoproliferative disorders of the skin, Experimental Dermatology, 14, 5, 2005. Crossref

  8. Varricchio Lilian, Tirelli Valentina, Masselli Elena, Ghinassi Barbara, Saha Nayanendu, Besmer Peter, Migliaccio Anna Rita, The Expression of the Glucocorticoid Receptor in Human Erythroblasts is Uniquely Regulated by KIT Ligand: Implications for Stress Erythropoiesis, Stem Cells and Development, 21, 15, 2012. Crossref

  9. Han Rong, Baden Howard P., Brissette Janice L., Weiner Lorin, Redefining the Skin's Pigmentary System with a Novel Tyrosinase Assay, Pigment Cell Research, 15, 4, 2002. Crossref

  10. Edling Charlotte E., Pedersen Malin, Carlsson Leif, Rönnstrand Lars, Palmer Ruth H., Hallberg Bengt, Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation, British Journal of Haematology, 136, 2, 2007. Crossref

  11. Looijenga Leendert H.J., Hersmus Remko, de Leeuw Bertie H.C.G.M., Stoop Hans, Cools Martine, Oosterhuis J. Wolter, Drop Stenvert L.S., Wolffenbuttel Katja P., Gonadal tumours and DSD, Best Practice & Research Clinical Endocrinology & Metabolism, 24, 2, 2010. Crossref

  12. Yoshida Chikamasa, Niiya Kenji, Niiya Masami, Shibakura Misako, Asaumi Noboru, Tanimoto Mitsune, Induction of urokinase-type plasminogen activator, interleukin-8 and early growth response-1 by STI571 through activating mitogen activated protein kinase in human small cell lung cancer cells, Blood Coagulation & Fibrinolysis, 18, 5, 2007. Crossref

  13. BLECHMAN JANNA M., YARDEN YOSEF, Structural Aspects of Receptor Dimerization., Annals of the New York Academy of Sciences, 766, 1 Receptor Acti, 1995. Crossref

  14. Arteaga Carlos L, Khuri Fadlo, Krystal Geoffrey, Sebti Said, Overview of rationale and clinical trials with signal transduction inhibitors in lung cancer, Seminars in Oncology, 29, 1, 2002. Crossref

  15. Sun Yan-Gang, Gracias Neilia G., Drobish Julie Kosto, Vasko Michael R., Gereau Robert W., Chen Zhou-Feng, The c-kit signaling pathway is involved in the development of persistent pain, Pain, 144, 1, 2009. Crossref

  16. Misago Noriyuki, Kimura Tetsunori, Narisawa Yutaka, Fibrofolliculoma/trichodiscoma and fibrous papule (perifollicular fibroma/angiofibroma): a revaluation of the histopathological and immunohistochemical features, Journal of Cutaneous Pathology, 36, 9, 2009. Crossref

  17. Sun Yuan-Chao, Cheng Shun-Feng, Sun Rui, Zhao Yong, Shen Wei, Reconstitution of Gametogenesis In Vitro: Meiosis Is the Biggest Obstacle, Journal of Genetics and Genomics, 41, 3, 2014. Crossref

  18. Leong Kevin G., Wang Bu-Er, Johnson Leisa, Gao Wei-Qiang, Generation of a prostate from a single adult stem cell, Nature, 456, 7223, 2008. Crossref

  19. Paietta Elisabeth, Andersen Janet, Yunis Jorge, Rowe Jacob M., Cassileth Peter A., Tallman Martin S., Bennett John M., Wiernik Peter H., Acute myeloid leukaemia expressing the leucocyte integrin CD11b - a new leukaemic syndrome with poor prognosis: result of an ECOG database analysis, British Journal of Haematology, 100, 2, 1998. Crossref

  20. Katz Menachem, Amit Ido, Yarden Yosef, Regulation of MAPKs by growth factors and receptor tyrosine kinases, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1773, 8, 2007. Crossref

  21. Wehrle-Haller Bernhard, Meller Margaret, Weston James A., Analysis of Melanocyte Precursors in Nf1 Mutants Reveals That MGF/KIT Signaling Promotes Directed Cell Migration Independent of Its Function in Cell Survival, Developmental Biology, 232, 2, 2001. Crossref

  22. Tharp Michael D., New insights into tissue mast cells, Current Problems in Dermatology, 13, 3, 2001. Crossref

  23. Avraham Hava, Price Daniel J., Regulation of Megakaryocytopoiesis and Platelet Production by Tyrosine Kinases and Tyrosine Phosphatases, Methods, 17, 3, 1999. Crossref

  24. Gargett Caroline E., Cervelló Irene, Hubbard Sonya, Simón Carlos, Adult Stem Cells in the Human Endometrium, in Stem Cells in Human Reproduction, 2009. Crossref

  25. Gargett Caroline E., Cervelló Irene, Hubbard Sonya, Simón Carlos, Adult Stem Cells in the Human Endometrium, in Stem Cells in Human Reproduction, 2009. Crossref

  26. Murray Nevin, Salgia Ravi, Fossella Frank V, Targeted molecules in small cell lung cancer, Seminars in Oncology, 31, 2004. Crossref

  27. Schenone S., Bruno O., Ranise A., Bondavalli F., Brullo C., Fossa P., Mosti L., Menozzi G., Carraro F., Naldini A., Bernini C., Manetti F., Botta M., New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation, Bioorganic & Medicinal Chemistry Letters, 14, 10, 2004. Crossref

  28. Bedell Mary A., Zama Aparna Mahakali, Genetic Analysis of Kit Ligand Functions During Mouse Spermatogenesis, Journal of Andrology, 25, 2, 2004. Crossref

  29. Tharp Michael D., Mastocytosis, Current Problems in Dermatology, 10, 5, 1998. Crossref

  30. Uzan Catherine, Cortez Annie, Dufournet Charlotte, Fauvet Raffaèle, Siffroi Jean-Pierre, Daraï Emile, Endometrium from women with and without endometriosis, and peritoneal, ovarian and bowel endometriosis, show different c-kit protein expression, Journal of Reproductive Immunology, 65, 1, 2005. Crossref

  31. Meco Daniela, Riccardi Anna, Servidei Tiziana, Brueggen Josef, Gessi Marco, Riccardi Riccardo, Dominici Carlo, Antitumor activity of imatinib mesylate in neuroblastoma xenografts, Cancer Letters, 228, 1-2, 2005. Crossref

  32. Loveland K., Meyts E. Rajpert-De, Veeramachaneni D.N.R., Testicular Cancer, in Comprehensive Toxicology, 2010. Crossref

  33. Koenig Joyce M, Baron Senen, Luo Defang, Benson Neal A, Deisseroth Albert B, L-Selectin Expression Enhances Clonogenesis of CD34+ Cord Blood Progenitors, Pediatric Research, 45, 6, 1999. Crossref

  34. Kroiher Michael, Reidling Jack C., Steele Robert E., A gene whose major transcript encodes only the substrate-binding domain of a protein-tyrosine kinase, Gene, 241, 2, 2000. Crossref

  35. Jagarlamudi Krishna, Reddy Pradeep, Adhikari Deepak, Liu Kui, Genetically modified mouse models for premature ovarian failure (POF), Molecular and Cellular Endocrinology, 315, 1-2, 2010. Crossref

  36. Johnson J. L., Kozysa A., Kharlamova A. V., Gulevich R. G., Perelman P. L., Fong H. W. F., Vladimirova A. V., Oskina I. N., Trut L. N., Kukekova A. V., Platinum coat color in red fox (Vulpes vulpes) is caused by a mutation in an autosomal copy ofKIT, Animal Genetics, 46, 2, 2015. Crossref

  37. Tharp Michael D., Longley B. Jack, MASTOCYTOSIS, Dermatologic Clinics, 19, 4, 2001. Crossref

  38. Dai Mu-Shui, Heinrich Michael C, Broxmeyer Hal E, Lu Li, Enhancing effects of co-transduction of both human erythropoietin receptor and c-kitcDNAs into hematopoietic stem/progenitor cells from cord blood on proliferation and differentiation of erythroid progenitors, Cytokines, Cellular & Molecular Therapy, 6, 1, 2000. Crossref

  39. Cho Nam Hoon, Park Young Kyu, Kim Young Tae, Yang Hyunwon, Kim Sei Kwang, Lifetime expression of stem cell markers in the uterine endometrium, Fertility and Sterility, 81, 2, 2004. Crossref

  40. Weissman Irving, Hematopoietic Stem Cells, Regenerative Medicine, and Leukemogenesis, in Thomas’ Hematopoietic Cell Transplantation, 2016. Crossref

  41. Shamblott Michael J., Kerr Candace L., Axelman Joyce, Littlefield John W., Clark Gregory O., Patterson Ethan S., Addis Russell C., Kraszewski Jennifer N., Kent Kathleen C., Gearhart John D., Derivation and Differentiation of Human Embryonic Germ Cells, in Handbook of Stem Cells, 2004. Crossref

  42. Ke Hengning, Kazi Julhash U., Zhao Hui, Sun Jianmin, Germline mutations of KIT in gastrointestinal stromal tumor (GIST) and mastocytosis, Cell & Bioscience, 6, 1, 2016. Crossref

  43. Clump David A., Clump David A., Qazi Ihtishaam H., Clump David A., Qazi Ihtishaam H., Sudol Marius, Flynn Daniel C., c-Yes response to growth factor activation, Growth Factors, 23, 4, 2005. Crossref

  44. Lennartsson Johan, Rönnstrand Lars, Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications, Physiological Reviews, 92, 4, 2012. Crossref

  45. Saiti Deshira, Lacham-Kaplan Orly, Mouse Germ Cell Developmentin-vivoandin-vitro, Biomarker Insights, 2, 2007. Crossref

  46. Aoki Hitomi, Hara Akira, Kunisada Takahiro, Induced haploinsufficiency of Kit receptor tyrosine kinase impairs brain development, JCI Insight, 2, 19, 2017. Crossref

  47. Mahakali Zama Aparna, Hudson F. Parker, Bedell Mary A., Analysis of Hypomorphic KitlSl Mutants Suggests Different Requirements for KITL in Proliferation and Migration of Mouse Primordial Germ Cells1, Biology of Reproduction, 73, 4, 2005. Crossref

  48. Cervelló I., Martínez-Conejero J.A., Horcajadas J.A., Pellicer A., Simón C., Identification, characterization and co-localization of label-retaining cell population in mouse endometrium with typical undifferentiated markers, Human Reproduction, 22, 1, 2007. Crossref

  49. Huang Chris T.F., Weitsman Stacy R., Dykes Barbara N., Magoffin Denis A., Stem Cell Factor and Insulin-Like Growth Factor-I Stimulate Luteinizing Hormone-Independent Differentiation of Rat Ovarian Theca Cells1, Biology of Reproduction, 64, 2, 2001. Crossref

  50. Martinez-Anton Asuncion, Gras Delphine, Bourdin Arnaud, Dubreuil Patrice, Chanez Pascal, KIT as a therapeutic target for non-oncological diseases, Pharmacology & Therapeutics, 197, 2019. Crossref

  51. Westphal Manfred, Black Peter McL., Perspectives of Cellular and Molecular Neurosurgery, Journal of Neuro-Oncology, 70, 2, 2004. Crossref

  52. Hunter Tony, THE CROONIAN LECTURE 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease, Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 353, 1368, 1998. Crossref

  53. Maulik Nilanjana, Maulik Gautam, Involvement of Receptor Tyrosine Kinases in Lung Cancer, in Phytopharmaceuticals in Cancer Chemoprevention, 20041296, 2004. Crossref

  54. Donovan Peter J., Miguel Maria P., The Role of the C-Kit/Kit Ligand Axis in Mammalian Gametogenesis, in Transgenics in Endocrinology, 2001. Crossref

  55. Potter Mark D., Shinpock Sarah G., Popp Raymond A., Popp Diana M., Godfrey Virginia, Carpenter Donald A., Bernstein Alan, Johnson Dabney K., Rinchik Eugene M., Mutations in the Murine Fitness 1 Gene Result in Defective Hematopoiesis, Blood, 90, 5, 1997. Crossref

  56. FÉSÜS László, SARLÓS Péter, OSVÁTH Zsuzsanna, ZSOLNAI Attila, KOMLÓSI István, RÁTKY József, Influence of the Dominant White/KIT Genotypes on the Reproductive Organs of Pigs, Journal of Reproduction and Development, 52, 6, 2006. Crossref

  57. Looijenga Leendert H. J., Risk Factors and Genetical Characterization, in Cancer of the Testis, 2011. Crossref

  58. Chitu Violeta, Caescu Cristina I., Stanley E. Richard, Lennartsson Johan, Rönnstrand Lars, Heldin Carl-Henrik, The PDGFR Receptor Family, in Receptor Tyrosine Kinases: Family and Subfamilies, 2015. Crossref

  59. Sui Xingwei, Krantz Sanford B., You Min, Zhao Zhizhuang, Synergistic Activation of MAP Kinase (ERK1/2) by Erythropoietin and Stem Cell Factor Is Essential for Expanded Erythropoiesis, Blood, 92, 4, 1998. Crossref

  60. Sui Xingwei, Krantz Sanford B., You Min, Zhao Zhizhuang, Synergistic Activation of MAP Kinase (ERK1/2) by Erythropoietin and Stem Cell Factor Is Essential for Expanded Erythropoiesis, Blood, 92, 4, 1998. Crossref

  61. Alessandro R., Spoonster J., Wersto R. P., Kohn E. C., Signal Transduction As a Therapeutic Target, in Attempts to Understand Metastasis Formation III, 213/3, 1996. Crossref

  62. Jones M., Sergeant C., Richardson M., Groth D., Brooks S., Munyard K., A non‐synonymous SNP in exon 3 of the KIT gene is responsible for the classic grey phenotype in alpacas ( Vicugna pacos ) , Animal Genetics, 50, 5, 2019. Crossref

  63. Elmore Lynne W., Domson Kelly, Moore Jonathan R., Kornstein Michael, Burks R. Tucker, Expression of c-Kit (CD117) in Benign and Malignant Human Endometrial Epithelium, Archives of Pathology & Laboratory Medicine, 125, 1, 2001. Crossref

  64. Chen Jing, Li Xiao-Bo, Su Rui, Song Li, Wang Fang, Zhang Jun-Wu, ZNF16 (HZF1) promotes erythropoiesis and megakaryocytopoiesis via regulation of the c-KIT gene, Biochemical Journal, 458, 1, 2014. Crossref

  65. Papathanasiou Peter, Goodnow Christopher C., Connecting Mammalian Genome with Phenome by ENU Mouse Mutagenesis: Gene Combinations Specifying the Immune System, Annual Review of Genetics, 39, 1, 2005. Crossref

  66. de Melo Maia Beatriz, Lavorato-Rocha André Mourão, Rodrigues Iara Sant’Ana, Baiocchi Glauco, Cestari Flávia Munhoz, Stiepcich Monica Maria, Chinen Ludmila Thomé Domingues, Carvalho Kátia C, Soares Fernando Augusto, Rocha Rafael Malagoli, Prognostic significance of c-KIT in vulvar cancer: bringing this molecular marker from bench to bedside, Journal of Translational Medicine, 10, 1, 2012. Crossref

  67. Wang Weina, Shui Liyan, Liu Yanning, Zheng Min, C-Kit, a Double-Edged Sword in Liver Regeneration and Diseases, Frontiers in Genetics, 12, 2021. Crossref

  68. Marklund Stefan, Kijas James, Rodriguez-Martinez Heriberto, Rönnstrand Lars, Funa Keiko, Moller Maria, Lange Dirk, Edfors-Lilja Inger, Andersson Leif, Molecular Basis for the Dominant White Phenotype in the Domestic Pig, Genome Research, 8, 8, 1998. Crossref

  69. Thompson Damien, Miller Charlotte, McCarthy Florence O., Computer Simulations Reveal a Novel Nucleotide-Type Binding Orientation for Ellipticine-Based Anticancer c-kit Kinase Inhibitors, Biochemistry, 47, 39, 2008. Crossref

  70. Goding Colin R., Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage, Genes & Development, 14, 14, 2000. Crossref

  71. Lennartsson Johan, Jelacic Tanya, Linnekin Diana, Shivakrupa R., Normal and Oncogenic Forms of the Receptor Tyrosine Kinase Kit, STEM CELLS, 23, 1, 2005. Crossref

  72. Turnpenny Lee, Spalluto Cosma M., Perrett Rebecca M., O'Shea Marie, Hanley Karen Piper, Cameron Iain T., Wilson David I., Hanley Neil A., Evaluating Human Embryonic Germ Cells: Concord and Conflict as Pluripotent Stem Cells, Stem Cells, 24, 2, 2006. Crossref

  73. Rajaraman S, Davis W S, Mahakali-Zama A, Evans H K, Russell L B, Bedell M A, An Allelic Series of Mutations in the Kit ligand Gene of Mice. I. Identification of Point Mutations in Seven Ethylnitrosourea-Induced KitlSteel Alleles, Genetics, 162, 1, 2002. Crossref

  74. De Miguel Maria P., Cheng Linzhao, Holland Eric C., Federspiel Mark J., Donovan Peter J., Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer, Proceedings of the National Academy of Sciences, 99, 16, 2002. Crossref

  75. He Jianglin, deCastro Carlos M., Vandenbark George R., Busciglio Jorge, Gabuzda Dana, Astrocyte apoptosis induced by HIV-1 transactivation of the c -kit  protooncogene , Proceedings of the National Academy of Sciences, 94, 8, 1997. Crossref

  76. Hotte Sébastien J., Winquist Eric W., Lamont Elizabeth, MacKenzie Mary, Vokes Everett, Chen Eric X., Brown Shirley, Pond Gregory R., Murgo Anthony, Siu Lillian L., Imatinib Mesylate in Patients With Adenoid Cystic Cancers of the Salivary Glands Expressing c-kit: A Princess Margaret Hospital Phase II Consortium Study, Journal of Clinical Oncology, 23, 3, 2005. Crossref

  77. Rubin Brian P., Antonescu Cristina R., Scott-Browne James P., Comstock Melissa L., Gu Yansong, Tanas Munir R., Ware Carol B., Woodell Jessica, A Knock-In Mouse Model of Gastrointestinal Stromal Tumor Harboring Kit K641E, Cancer Research, 65, 15, 2005. Crossref

  78. Rajaraman S, Davis W S, Mahakali-Zama A, Evans H K, Russell L B, Bedell M A, An Allelic Series of Mutations in the Kit ligand Gene of Mice. II. Effects of Ethylnitrosourea-Induced Kitl Point Mutations on Survival and Peripheral Blood Cells of KitlSteel Mice, Genetics, 162, 1, 2002. Crossref

  79. Krams Matthias, Parwaresch Reza, Sipos Bence, Heidorn Klaus, Harms Dieter, Rudolph Pierre, Expression of the c-kit receptor characterizes a subset of neuroblastomas with favorable prognosis, Oncogene, 23, 2, 2004. Crossref

  80. Trophoblast, amniotic fluid, endometrium, and bone marrow, in Stem Cells in Reproductive Medicine, 2013. Crossref

  81. Gargett Caroline E., Cervelló Irene, Nguyen Hong P.T., Simón Carlos, Adult stem cells in the human endometrium, in Stem Cells in Reproductive Medicine, 2013. Crossref

  82. Abrams Tinya, Connor Anu, Fanton Christie, Cohen Steven B., Huber Thomas, Miller Kathy, Hong E. Erica, Niu Xiaohong, Kline Janine, Ison-Dugenny Marjorie, Harris Sarah, Walker Dana, Krauser Klaus, Galimi Francesco, Wang Zhen, Ghoddusi Majid, Mansfield Keith, Lee-Hoeflich Si Tuen, Holash Jocelyn, Pryer Nancy, Kluwe William, Ettenberg Seth A., Sellers William R., Lees Emma, Kwon Paul, Abraham Judith A., Schleyer Siew C., Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors, Clinical Cancer Research, 24, 17, 2018. Crossref

  83. Hsu Yueh-Rong, Wu Gay-May, Mendiaz Elizabeth A., Syed Rashid, Wypych Jette, Toso Robert, Mann Michael B., Boone Thomas C., Narhi Linda O., Lu Hsieng S., Langley Keith E., The Majority of Stem Cell Factor Exists as Monomer under Physiological Conditions, Journal of Biological Chemistry, 272, 10, 1997. Crossref

Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa Políticas de preços e assinaturas Begell House Contato Language English 中文 Русский Português German French Spain