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Critical Reviews™ in Oncogenesis

Publicou 4 edições por ano

ISSN Imprimir: 0893-9675

ISSN On-line: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Regulation of Normal and Transformed Tracheobronchial Epithelial Cell Proliferation by Autocrine Growth Factors

Volume 5, Edição 2-3, 1994, pp. 107-120
DOI: 10.1615/CritRevOncog.v5.i2-3.10
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RESUMO

Several peptide growth factors have been identified as autocrine regulators of normal tracheobronchial epithelial cells, including the transforming growth factors alpha and beta. Using in vitro tissue culture models of multistep neoplastic transformation as well as cell lines derived from human bronchogenic tumors, a significant number of growth factors have been found to function as autocrine factors for neoplastic tracheobronchial cells as well. In several instances, the regulation of the autocrine pathway is disrupted in neoplastic tracheobroncial cells compared with their normal counterparts. These results indicate that there are multiple aberrations in growth factor pathways occurring in tracheobronchial epithelial cells during progression to the neoplastic phenotype.

CITADO POR
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  4. Jyonouchi Harumi, Sun Sining, Abiru Toichi, Chareancholvanich Satanoon, Ingbar David H., The Effects of Hyperoxic Injury and Antioxidant Vitamins on Death and Proliferation of Human Small Airway Epithelial Cells, American Journal of Respiratory Cell and Molecular Biology, 19, 3, 1998. Crossref

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