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Critical Reviews™ in Oncogenesis

Publicou 4 edições por ano

ISSN Imprimir: 0893-9675

ISSN On-line: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Targeting the Human Kinome for Cancer Therapy: Current Perspectives

Volume 17, Edição 2, 2012, pp. 233-246
DOI: 10.1615/CritRevOncog.v17.i2.70
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RESUMO

As highlighted by other articles in this review issue, great progress has been made in the development of targeted treatment modalities directed against particular oncogenic kinases, and the translation of these therapies into the clinic. However, recent data from cancer genome sequencing projects indicate that the spectrum of kinases that contribute to cancer progression is wider than previously imagined, and as international projects in this area gather momentum, it appears likely that further kinase oncogenes will be identified, and the roles of previously characterized ones will be extended to subsets of additional cancers. In addition, complementary approaches such as functional genomics and mass spectrometry (MS)-based proteomics are providing important insights into the functional roles played by specific kinases in particular cancers, the dependency of these roles on genetic background, how altered kinase regulation perturbs intracellular signaling networks, and how the latter respond to targeted agents that target the kinase in question. While other articles in this issue focus on individual cancer-associated kinases and their therapeutic targeting, the aim of this review is to take a broader perspective regarding our current knowledge of the cancer kinome and how this can be expanded and exploited for clinical utility.

CITADO POR
  1. Mahajan Kiran, Mahajan Nupam P., ACK1 tyrosine kinase: Targeted inhibition to block cancer cell proliferation, Cancer Letters, 338, 2, 2013. Crossref

  2. Wong Stephen Q., Li Jason, Salemi Renato, Sheppard Karen E., Hongdo Do , Tothill Richard W., McArthur Grant A., Dobrovic Alexander, Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours, Scientific Reports, 3, 1, 2013. Crossref

  3. Allen Charlotte E., Chow Chiau L., Caldwell John J., Westwood Isaac M., M. van Montfort Rob L., Collins Ian, Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases, Bioorganic & Medicinal Chemistry, 21, 18, 2013. Crossref

  4. Damayanti Nur P., Parker Laurie L., Irudayaraj Joseph M. K., Fluorescence Lifetime Imaging of Biosensor Peptide Phosphorylation in Single Live Cells, Angewandte Chemie International Edition, 52, 14, 2013. Crossref

  5. Damayanti Nur P., Parker Laurie L., Irudayaraj Joseph M. K., Fluorescence Lifetime Imaging of Biosensor Peptide Phosphorylation in Single Live Cells, Angewandte Chemie, 125, 14, 2013. Crossref

  6. Nobis Max, Carragher Neil O., McGhee Ewan J., Morton Jennifer P., Sansom Owen J., Anderson Kurt I., Timpson Paul, Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue, FEBS Journal, 280, 21, 2013. Crossref

  7. Cierpicki Tomasz, Grembecka Jolanta, Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?, Immunological Reviews, 263, 1, 2015. Crossref

  8. Torii M., Li G., Li Z., Oughtred R., Diella F., Celen I., Arighi C. N., Huang H., Vijay-Shanker K., Wu C. H., RLIMS-P: an online text-mining tool for literature-based extraction of protein phosphorylation information, Database, 2014, 2014. Crossref

  9. DeMille Desiree, Bikman Benjamin T., Mathis Andrew D., Prince John T., Mackay Jordan T., Sowa Steven W., Hall Tacie D., Grose Julianne H., Boone Charles, A comprehensive protein–protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1, Molecular Biology of the Cell, 25, 14, 2014. Crossref

  10. Kathiriya Jaymin J., Pathak Ravi Ramesh, Clayman Eric, Xue Bin, Uversky Vladimir N., Davé Vrushank, Presence and utility of intrinsically disordered regions in kinases, Mol. BioSyst., 10, 11, 2014. Crossref

  11. DeMille Desiree, Badal Bryan D., Evans J. Brady, Mathis Andrew D., Anderson Joseph F., Grose Julianne H., Lew Daniel J., PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1, Molecular Biology of the Cell, 26, 3, 2015. Crossref

  12. Kooistra Albert J., Volkamer Andrea, Kinase-Centric Computational Drug Development, in Platform Technologies in Drug Discovery and Validation, 50, 2017. Crossref

  13. Cann Marissa L., McDonald Ian M., East Michael P., Johnson Gary L., Graves Lee M., Measuring Kinase Activity—A Global Challenge, Journal of Cellular Biochemistry, 118, 11, 2017. Crossref

  14. Hinzman Charles P, Aljehane Leala, Brown-Clay Joshua D, Kallakury Bhaskar, Sonahara Fuminori, Goel Ajay, Trevino Jose, Banerjee Partha P, Aberrant expression of PDZ-binding kinase/T-LAK cell-originated protein kinase modulates the invasive ability of human pancreatic cancer cells via the stabilization of oncoprotein c-MYC, Carcinogenesis, 39, 12, 2018. Crossref

  15. Raja Kalpana, Natarajan Jeyakumar, Mining protein phosphorylation information from biomedical literature using NLP parsing and Support Vector Machines, Computer Methods and Programs in Biomedicine, 160, 2018. Crossref

  16. Liu Yu-Ching, Tsai Fuu-Jen, Chen Chao-Jung, A rapid, multiplexed kinase activity assay using 8-plex iTRAQ labeling, SPE, and MALDI-TOF/TOF MS, The Analyst, 145, 3, 2020. Crossref

  17. Ostacolo Carmine, Di Sarno Veronica, Lauro Gianluigi, Pepe Giacomo, Musella Simona, Ciaglia Tania, Vestuto Vincenzo, Autore Giuseppina, Bifulco Giuseppe, Marzocco Stefania, Campiglia Pietro, Gomez-Monterrey Isabel M., Bertamino Alessia, Identification of an indol-based multi-target kinase inhibitor through phenotype screening and target fishing using inverse virtual screening approach, European Journal of Medicinal Chemistry, 167, 2019. Crossref

  18. Zhang Luxi, Holmes Ian P., Hochgräfe Falko, Walker Scott R., Ali Naveid A., Humphrey Emily S., Wu Jianmin, de Silva Melanie, Kersten Wilhelmus J. A., Connor Theresa, Falk Hendrik, Allan Lynda, Street Ian P., Bentley John D., Pilling Patricia A., Monahan Brendon J., Peat Thomas S., Daly Roger J., Characterization of the Novel Broad-Spectrum Kinase Inhibitor CTx-0294885 As an Affinity Reagent for Mass Spectrometry-Based Kinome Profiling, Journal of Proteome Research, 12, 7, 2013. Crossref

  19. D'Amore Claudio, Moro Enrico, Borgo Christian, Itami Kenichiro, Hirota Tsuyoshi, Pinna Lorenzo A., Salvi Mauro, “Janus” efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1867, 11, 2020. Crossref

  20. Merget Benjamin, Turk Samo, Eid Sameh, Rippmann Friedrich, Fulle Simone, Profiling Prediction of Kinase Inhibitors: Toward the Virtual Assay, Journal of Medicinal Chemistry, 60, 1, 2017. Crossref

  21. Volkamer Andrea, Eid Sameh, Turk Samo, Jaeger Sabrina, Rippmann Friedrich, Fulle Simone, Pocketome of Human Kinases: Prioritizing the ATP Binding Sites of (Yet) Untapped Protein Kinases for Drug Discovery, Journal of Chemical Information and Modeling, 55, 3, 2015. Crossref

  22. Tothill Richard W, Li Jason, Mileshkin Linda, Doig Ken, Siganakis Terence, Cowin Prue, Fellowes Andrew, Semple Timothy, Fox Stephen, Byron Keith, Kowalczyk Adam, Thomas David, Schofield Penelope, Bowtell David D, Massively‐parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary, The Journal of Pathology, 231, 4, 2013. Crossref

  23. McCullumsmith Robert E, Hammond John H, Shan Dan, Meador-Woodruff James H, Postmortem Brain: An Underutilized Substrate for Studying Severe Mental Illness, Neuropsychopharmacology, 39, 1, 2014. Crossref

  24. Dimitrakopoulos Lampros, Prassas Ioannis, Diamandis Eleftherios P., Charames George S., Onco-proteogenomics: Multi-omics level data integration for accurate phenotype prediction, Critical Reviews in Clinical Laboratory Sciences, 54, 6, 2017. Crossref

  25. Lin Shu-Yu, Chang Chun-Feng, Coumar Mohane Selvaraj, Chen Pei-Yi, Kuo Fu-Ming, Chen Chun-Hwa, Li Mu-Chun, Lin Wen-Hsing, Kuo Po-Chu, Wang Sing-Yi, Li An-Siou, Lin Chin-Yu, Yang Chen-Ming, Yeh Teng-Kuang, Song Jen-Shin, Hsu John T.A., Hsieh Hsing-Pang, Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors, Bioorganic Chemistry, 98, 2020. Crossref

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