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Plasma Medicine

Publicou 4 edições por ano

ISSN Imprimir: 1947-5764

ISSN On-line: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

Indexed in

Universality of Micromolar-Level Cell-Based Hydrogen Peroxide Generation during Direct Cold Atmospheric Plasma Treatment

Volume 8, Edição 4, 2018, pp. 335-343
DOI: 10.1615/PlasmaMed.2018028781
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RESUMO

Understanding the interaction between cold atmospheric plasma (CAP) and cells is a critical challenge in plasma medicine. CAP has shown promising application for cancer treatment. To date, dozens of cancer cells have been selectively killed during in vitro studies, and CAP-originated reactive species have been regarded to be the primary factor causing cancer cell death. In the past, we investigated hydrogen peroxide (H2O2) generation at the micromolar level using two CAP-treated cancer cell lines. In this study, we further demonstrate the universality of such strong cell-based H2O2 generation in eight cancer cell lines. Nearly all lines showed capacity to generate a micromolar level of H2O2 during 1 min of CAP treatment when discharge voltage (peak value) was > 3.30 kV. Generally, higher discharge voltage corresponds to stronger cell-based H2O2 generation, although some cell lines produce maximum H2O2 generation at relatively low discharge voltage. Cell-based H2O2 generation may involve interaction between cancer cells and reactive oxygen species in CAP. The CAP optical emission spectrum demonstrates a significant increase in singlet oxygen (O) and hydroxyl (OH) radicals in CAP when discharge voltage is > 3.30 kV. This study demonstrates the universality of cell-based H2O2 generation that has not been considered in previous studies.

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CITADO POR
  1. Malyavko Alisa, Yan Dayun, Wang Qihui, Klein Andrea L., Patel Khyati C., Sherman Jonathan H., Keidar Michael, Cold atmospheric plasma cancer treatment, direct versus indirect approaches, Materials Advances, 1, 6, 2020. Crossref

  2. Zhang Jishen, Li Bing, Xu Shengduo, Liu Dingxin, Zhang Hao, Xu Dehui, Guo Li, Kong Michael G., Study of the anticancer effects of a helium plasma jet combined with four anticancer drugs on 3D bladder tumour spheroids, Plasma Processes and Polymers, 18, 5, 2021. Crossref

  3. Yan Dayun, Malyavko Alisa, Wang Qihui, Ostrikov Kostya (Ken), Sherman Jonathan H., Keidar Michael, Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism, Biomedicines, 9, 9, 2021. Crossref

  4. Yan Dayun, Wang Qihui, Adhikari Manish, Malyavko Alisa, Lin Li, Zolotukhin Denis B., Yao Xiaoliang, Kirschner Megan, Sherman Jonathan H., Keidar Michael, A Physically Triggered Cell Death via Transbarrier Cold Atmospheric Plasma Cancer Treatment, ACS Applied Materials & Interfaces, 12, 31, 2020. Crossref

  5. Yan Dayun, Malyavko Alisa, Wang Qihui, Lin Li, Sherman Jonathan H., Keidar Michael, Cold Atmospheric Plasma Cancer Treatment, a Critical Review, Applied Sciences, 11, 16, 2021. Crossref

  6. Yan Dayun, Horkowitz Alex, Wang Qihui, Keidar Michael, On the selective killing of cold atmospheric plasma cancer treatment: Status and beyond, Plasma Processes and Polymers, 18, 10, 2021. Crossref

  7. Laroussi Mounir, Bekeschus Sander, Keidar Michael, Bogaerts Annemie, Fridman Alexander, Lu Xinpei, Ostrikov Kostya, Hori Masaru, Stapelmann Katharina, Miller Vandana, Reuter Stephan, Laux Christophe, Mesbah Ali, Walsh James, Jiang Chunqi, Thagard Selma Mededovic, Tanaka Hiromasa, Liu Dawei, Yan Dayun, Yusupov Maksudbek, Low-Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap, IEEE Transactions on Radiation and Plasma Medical Sciences, 6, 2, 2022. Crossref

  8. Limanowski Ruby, Yan Dayun, Li Lin, Keidar Michael, Preclinical Cold Atmospheric Plasma Cancer Treatment, Cancers, 14, 14, 2022. Crossref

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