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Plasma Medicine

Publicou 4 edições por ano

ISSN Imprimir: 1947-5764

ISSN On-line: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

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DNA Damage in Mammalian Cells by Atmospheric Pressure Microsecond-Pulsed Dielectric Barrier Discharge Plasma Is Not Mediated Via Lipid Peroxidation

Volume 1, Edição 2, 2011, pp. 167-177
DOI: 10.1615/PlasmaMed.2011003798
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RESUMO

Lipid peroxidation in mammalian cells by nonthermal atmospheric pressure microsecond-pulsed dielectric barrier discharge plasma was investigated. It has been shown previously that plasma treatment of mammalian cells submerged in a shallow layer of culture medium can result in dose-dependent DNA damage. We show that nonthermal plasma induces lipid peroxidation, measured by release of malondialdehyde, in cells treated under medium and not under phosphate-buffered saline. N-Diphenyl-phenylenediamine, a lipophilic anti-oxidant, was used to block nonthermal plasma-induced lipid peroxidation. Although nonthermal plasma induces lipid peroxidation in mammalian cells, this peroxidation does not lead to DNA damage in mammalian cells. Thus, one needs to consider other possible mechanisms for plasma-induced DNA damage in mammalian cells such as reactive oxygen species signaling or active transport of long-lived organic hydroperoxides.

CITADO POR
  1. Haertel Beate, Woedtke Thomas von, Weltmann Klaus-Dieter, Lindequist Ulrike, Non-Thermal Atmospheric-Pressure Plasma Possible Application in Wound Healing, Biomolecules & Therapeutics, 22, 6, 2014. Crossref

  2. Kluge Susanne, Bekeschus Sander, Bender Claudia, Benkhai Hicham, Sckell Axel, Below Harald, Stope Matthias B., Kramer Axel, Yousfi Mohammed, Investigating the Mutagenicity of a Cold Argon-Plasma Jet in an HET-MN Model, PLOS ONE, 11, 9, 2016. Crossref

  3. Arjunan Krishna, Sharma Virender, Ptasinska Sylwia, Effects of Atmospheric Pressure Plasmas on Isolated and Cellular DNA—A Review, International Journal of Molecular Sciences, 16, 2, 2015. Crossref

  4. Weiss M., Daeschlein G., Kramer A., Burchardt M., Brucker S., Wallwiener D., Stope M. B., Virucide properties of cold atmospheric plasma for future clinical applications, Journal of Medical Virology, 89, 6, 2017. Crossref

  5. Boehm Daniela, Bourke Paula, Safety implications of plasma-induced effects in living cells – a review of in vitro and in vivo findings, Biological Chemistry, 400, 1, 2018. Crossref

  6. Zhang Jiao, Kwon Taeho, Kim Seong, Jeong Dong, Plasma Farming: Non-Thermal Dielectric Barrier Discharge Plasma Technology for Improving the Growth of Soybean Sprouts and Chickens, Plasma, 1, 2, 2018. Crossref

  7. Pasqual-Melo Gabriella, Nascimento Thiago, Sanches Larissa Juliani, Blegniski Fernanda Paschoal, Bianchi Julya Karen, Sagwal Sanjeev Kumar, Berner Julia, Schmidt Anke, Emmert Steffen, Weltmann Klaus-Dieter, von Woedtke Thomas, Gandhirajan Rajesh Kumar, Cecchini Alessandra Lourenço, Bekeschus Sander, Plasma Treatment Limits Cutaneous Squamous Cell Carcinoma Development In Vitro and In Vivo, Cancers, 12, 7, 2020. Crossref

  8. Schmidt Anke, Bekeschus Sander, How Safe is Plasma Treatment in Clinical Applications?, in Textbook of Good Clinical Practice in Cold Plasma Therapy, 2022. Crossref

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