Inscrição na biblioteca: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Publicou 6 edições por ano

ISSN Imprimir: 1045-4403

ISSN On-line: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Regulation of the Chicken Lysozyme Locus in Transgenic Mice

Volume 6, Edição 2-3, 1996, pp. 285-297
DOI: 10.1615/CritRevEukarGeneExpr.v6.i2-3.90
Get accessGet access

RESUMO

The chicken lysozyme locus is transcriptionally activated during macrophage differentiation. Each cis-regulatory element has its unique activation stage during cell differentiation, whereby maximal transcriptional activity of the gene is only observed when all cis-elements are active. The complete chicken lysozyme locus is expressed position independently and at a high level in macrophages of transgenic mice. For correct transgene regulation, the cooperation of all cis-regulatory elements is required. These cis-regulatory elements specify the mode of regulation and we observe the same expression pattern of the transgene in the mouse and the endogenous gene in chicken macrophages. This indicates that the transcription factors responsible for chicken lysozyme regulation are highly conserved in evolution. The endogenous mouse lysozyme gene is regulated differently. The chromatin of the lysozyme locus is highly structured in the transcriptionally active, as well as in the inactive state. The transcriptional activation of the lysozyme locus is accompanied by extensive chromatin rearrangements, which are disturbed when one essential cis-regulatory element is deleted and the transgenes are subjects to genomic position effects. Based on these results, we propose that a distinct chromatin architecture of a gene locus is required for its correct activation.

CITADO POR
  1. Razin Sergey V, Farrell Catherine M, Recillas-Targa Félix, , 226, 2003. Crossref

  2. Irwin David M, Evolution of the vertebrate goose-type lysozyme gene family, BMC Evolutionary Biology, 14, 1, 2014. Crossref

  3. Åstrand Carolina, Belikov Sergey, Wrange Örjan, Histone acetylation characterizes chromatin presetting by NF1 and Oct1 and enhances glucocorticoid receptor binding to the MMTV promoter, Experimental Cell Research, 315, 15, 2009. Crossref

  4. Lee Gap Ryol, Fields Patrick E., Flavell Richard A., Regulation of IL-4 Gene Expression by Distal Regulatory Elements and GATA-3 at the Chromatin Level, Immunity, 14, 4, 2001. Crossref

  5. Kaetzel David M, Transcription of the platelet-derived growth factor A-chain gene, Cytokine & Growth Factor Reviews, 14, 5, 2003. Crossref

  6. Krüger Gudrun, Huber Matthias C, Bonifer Constanze, The −3.9 kb DNaseI hypersensitive site of the chicken lysozyme locus harbours an enhancer with unusual chromatin reorganizing activity, Gene, 236, 1, 1999. Crossref

  7. Lampard Gregory R, Gibbins Ann M. Verrinder, Secretion of foreign proteins mediated by chicken lysozyme gene regulatory sequences, Biochemistry and Cell Biology, 80, 6, 2002. Crossref

  8. Daugherty Alan, Kosswig Ninetta, Cornicelli Joseph A., Whitman Stewart C., Wolle Sabine, Rateri Debra L., Macrophage-specific expression of class A scavenger receptors enhances granuloma formation in the absence of increased lipid deposition, Journal of Lipid Research, 42, 7, 2001. Crossref

  9. Maul Raymond S., Zhang Hongxing, Reid James D., Pedigo Nancy G., Kaetzel David M., Identification of a Cell Type-specific Enhancer in the Distal 5′-Region of the Platelet-derived Growth Factor A-chain Gene, Journal of Biological Chemistry, 273, 50, 1998. Crossref

  10. Whitman Stewart C., Rateri Debra L., Szilvassy Stephen J., Cornicelli Joseph A., Daugherty Alan, Macrophage-specific expression of class A scavenger receptors in LDL receptor−/− mice decreases atherosclerosis and changes spleen morphology, Journal of Lipid Research, 43, 8, 2002. Crossref

  11. Wittkopp Patricia J., Variable gene expression in eukaryotes: a network perspective, Journal of Experimental Biology, 210, 9, 2007. Crossref

  12. Kontaraki Joanna, Chen Hsiu-Hua, Riggs Arthur, Bonifer Constanze, Chromatin fine structure profiles for a developmentally regulated gene: reorganization of the lysozyme locus before trans-activator binding and gene expression, Genes & Development, 14, 16, 2000. Crossref

Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa Políticas de preços e assinaturas Begell House Contato Language English 中文 Русский Português German French Spain