Publicou 6 edições por ano
ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502
Indexed in
Muscle-Based Gene Therapy and Tissue Engineering
RESUMO
The development of new biological approaches based on cell and gene therapies, in combination with tissue engineering, may create innovative ways to treat various tissues of the musculoskeletal system. It is vital for practicing orthopaedic surgeons to understand the terminology, fundamental concepts, and current research in this burgeoning field so that they may practice their discipline in its fullest form. Such techniques, coupled with advances in cell biology and polymer chemistry, are resulting in novel approaches to treating musculoskeletal disorders in which surgeons, who have traditionally used the tools of excision and reconstruction to treat patients, may now serve as surgical gardeners who create microenvironments that are conducive for tissue regeneration. Gene therapy and tissue engineering applications for bone healing, articular disorders, and skeletal muscle diseases and injuries are currently being explored. This review is intended to update readers on the principles and current advances in muscle-based gene therapy and tissue engineering for the musculoskeletal system.
-
Umehara Kohsuke, Iimura Tadahiro, Sakamoto Kei, Lin Zayar, Kasugai Shohei, Igarashi Yoshimasa, Yamaguchi Akira, Canine Oral Mucosal Fibroblasts Differentiate into Osteoblastic Cells in Response to BMP-2, The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 295, 8, 2012. Crossref
-
Garcia A.J., Guldberg R.E., Byers B.A., Gersbach C.A., Phillips J.E., Addressing cell-sourcing limitations with gene therapy, IEEE Engineering in Medicine and Biology Magazine, 22, 5, 2003. Crossref
-
Badylak Stephen F., Extracellular matrix as a scaffold for tissue engineering in veterinary medicine: Applications to soft tissue healing, Clinical Techniques in Equine Practice, 3, 2, 2004. Crossref
-
O'Rourke J.P, Hiraragi H, Urban K, Patel M, Olsen J.C, Bunnell B.A, Analysis of gene transfer and expression in skeletal muscle using enhanced EIAV lentivirus vectors, Molecular Therapy, 7, 5, 2003. Crossref
-
Young Brett H., Peng Hairong, Huard Johnny, Muscle-Based Gene Therapy and Tissue Engineering to Improve Bone Healing, Clinical Orthopaedics and Related Research, 403, 2002. Crossref
-
Hirata K, Tsukazaki T, Kadowaki A, Furukawa K, Shibata Y, Moriishi T, Okubo Y, Bessho K, Komori T, Mizuno A, Yamaguchi A, Transplantation of skin fibroblasts expressing BMP-2 promotes bone repair more effectively than those expressing Runx2, Bone, 32, 5, 2003. Crossref