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Critical Reviews™ in Eukaryotic Gene Expression

Publicou 6 edições por ano

ISSN Imprimir: 1045-4403

ISSN On-line: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

The Role of Cytokines and Growth Factors as Mediators of the Effects of Systemic Hormones at the Bone Local Level

Volume 5, Edição 3-4, 1995, pp. 193-217
DOI: 10.1615/CritRevEukarGeneExpr.v5.i3-4.10
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RESUMO

Bone tissue is being continuously remodeled by the integrated activity of bone-resorbing osteoclasts and bone-forming osteoblasts. Because bone remodeling takes place in discrete foci throughout the skeleton, local mechanisms must play a critical role in its regulation. Several cytokines and other locally released factors exert marked effects on bone cells. Many experimental studies show that calciotropic hormones modulate cytokine expression. Indeed, a number of studies suggest that cytokines are actually involved in the mechanisms that mediate the effects of calciotropic hormones at the areas of bone being remodeled. However, the results are often conflicting. Moreover, most published studies have been carried out by testing the effects of pharmacological concentrations of hormones on cytokine production by bone cells. This type of study often gives little information on the physiological role of the factors tested. Thus, although evidence for a role of cytokines as mediators of hormone effects at the bone local level is rapidly accumulating, more data are needed in order to better understand the actual role of those factors in bone physiology and pathophysiology. In vivo studies and particularly those analyzing the consequences of the lack of activity of a particular cytokine or hormone are likely to be particularly informative.

CITADO POR
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  3. Sunyer Teresa, Lewis Jennifer, Collin-Osdoby Patricia, Osdoby Philip, Estrogen’s bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells, Journal of Clinical Investigation, 103, 10, 1999. Crossref

  4. Collin-Osdoby Patricia, Rothe Linda, Bekker Simon, Anderson Fred, Osdoby Philip, Decreased Nitric Oxide Levels Stimulate Osteoclastogenesis and Bone Resorption Both in Vitro and in Vivo on the Chick Chorioallantoic Membrane in Association with Neoangiogenesis, Journal of Bone and Mineral Research, 15, 3, 2010. Crossref

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  6. Wu Yanhong, Haugen James D., Zinsmeister Alan R., Kumar Rajiv, 1α,25-Dihydroxyvitamin D3Increases Transforming Growth Factor and Transforming Growth Factor Receptor Type I and II Synthesis in Human Bone Cells, Biochemical and Biophysical Research Communications, 239, 3, 1997. Crossref

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