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Critical Reviews™ in Eukaryotic Gene Expression

Publicou 6 edições por ano

ISSN Imprimir: 1045-4403

ISSN On-line: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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ANP-NPRA Signaling Pathway−A Potential Therapeutic Target for the Treatment of Malignancy

Volume 23, Edição 2, 2013, pp. 93-101
DOI: 10.1615/CritRevEukarGeneExpr.2013006641
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RESUMO

It was well established that the atrial natriuretic peptide (ANP)/natriuretic peptide receptor-A (NPRA) signaling pathway controls natriuretic, diuretic, vasorelaxant, and anti-proliferative responses in the regulation of the human cardiovascular system by previous studies. Yet in recent years, more and more evidence has shown that the ANP/NPRA signaling pathway plays an important role in human cancer. For example, NPRA is abundantly expressed on tumorigenic mouse and human prostate cancer (PCa) cells, but not in nontumorigenic prostate epithelial cells and down-regulation of NPRA-induced apoptosis in PCa cells. Dexamethasone can increase the expression of ANP markedly, and that is the reason why dexamethasone is the cornerstone in the treatment of multiple myeloma. NPRA deficiency can substantially protect C57BL/6 mice from lung, skin, and ovarian cancers. These results strongly suggest ANP and NPRA may play an anti-cancer and carcinogenesis role, respectively, and this signaling pathway could be a more potent target for cancer therapy. In light of these new insights, this review will summarize the structures, functions, and their regulation by cell signaling, and their different impacts on tumors.

Palavras-chave: ANP, NPRA, cancer, target, treatment
CITADO POR
  1. Chen Yang, Li Tianyu, Yu Xiaoqiang, Xu Jianfeng, Li Jianling, Luo Dexiang, Mo Zengnan, Hu Yanling, The RTK/ERK pathway is associated with prostate cancer risk on the SNP level: A pooled analysis of 41 sets of data from case–control studies, Gene, 534, 2, 2014. Crossref

  2. Huang Liang-Ti, Chang Hsuen-Wen, Wu Min-Ju, Lai Yong-Tzuo, Wu Wen-Chi, Yu Winston C.Y., Chang Vincent H.S., Klf10 deficiency in mice exacerbates pulmonary inflammation by increasing expression of the proinflammatory molecule NPRA, The International Journal of Biochemistry & Cell Biology, 79, 2016. Crossref

  3. Mezzasoma Letizia, Peirce Matthew, Minelli Alba, Bellezza Ilaria, Natriuretic Peptides: The Case of Prostate Cancer, Molecules, 22, 10, 2017. Crossref

  4. Santhekadur Prasanna K., Kumar Divya P., Seneshaw Mulugeta, Mirshahi Faridoddin, Sanyal Arun J., The multifaceted role of natriuretic peptides in metabolic syndrome, Biomedicine & Pharmacotherapy, 92, 2017. Crossref

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