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Critical Reviews™ in Eukaryotic Gene Expression

Publicou 6 edições por ano

ISSN Imprimir: 1045-4403

ISSN On-line: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Role of Toll-Like Receptors in Hepatitis C Virus Pathogenesis and Treatment

Volume 26, Edição 4, 2016, pp. 353-362
DOI: 10.1615/CritRevEukaryotGeneExpr.2016017455
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RESUMO

Viral infections are rising every day, and viruses appear to be the most dangerous pathogens in the world. Hepatitis C virus (HCV) is accepted as one of the major destructive factors of promoting severe hepatic disorders by infecting more than 180 million individuals throughout the world. Chronic infection caused by HCV poses a serious global health emergency and appears to be a powerful threat to humanity. Almost 20 years have passed since the disclosure of HCV, but even now, treatment preferences remain limited. Humans are born with a rapid and nonspecific mechanism to prevent viral attacks through Toll-like receptors (TLRs), which are evolutionary conserved cellular activator proteins responsible for recognizing specific components present on penetrating microbes and viruses. Recent research efforts in TLR biology suggest that targeting the TLRs and their signaling pathways during HCV infection could contribute to novel therapies against HCV. The mobilization of TLRs boosts antiviral communication and integrates the development of long-lasting acquired immune responses to limit viral pathogenesis. Both activation and suppression of TLRs are necessary for the efficient treatment of HCV. For the proper management and eradication of HCV, novel drugs that target TLRs and their signaling pathway are needed. This review summarizes the role of TLR signaling in HCV infection and treatment.

CITADO POR
  1. Sghaier Ikram, Brochot Etienne, Loueslati Besma Y., Almawi Wassim Y., Hepatitis C virus protein interaction network for HCV clearance and association of DAA to HCC occurrence via data mining approach: A systematic review and critical analysis, Reviews in Medical Virology, 29, 2, 2019. Crossref

  2. Neag Maria Adriana, Mitre Andrei Otto, Catinean Adrian, Buzoianu Anca Dana, Overview of the microbiota in the gut-liver axis in viral B and C hepatitis, World Journal of Gastroenterology, 27, 43, 2021. Crossref

  3. Yousaf Muhammad, Junaid Kashaf, Iqbal Muhammad Sarfaraz, Aslam Imran, Ahmad Sheraz, Aqeel Muhammad, Ashfaq Usman Ali, Khaliq Saba, Ghani Muhammad Usman, Waqar Nayyar, Analysis of dengue virus burden and serotypes pattern in Faisalabad, 2016–2017, Future Virology, 13, 4, 2018. Crossref

  4. Iqbal Muhammad Sarfaraz, Ashfaq Usman Ali, Aslam Sadia, Khaliq Saba, Ghani Muhammad Usman, Batool Farzana, Analysis of polymorphism rs1990760 of IFIH1 gene and treatment outcomes in HCV infection, Future Virology, 13, 3, 2018. Crossref

  5. Gao Yang, Nepal Narayan, Jin Shi-Zhu, Toll-like receptors and hepatitis C virus infection, Hepatobiliary & Pancreatic Diseases International, 20, 6, 2021. Crossref

  6. Ghani Muhammad Usman, Haque Asma, Iqbal Muhammad Sarfaraz, Ashfaq Usman Ali, Mausood Muhammad Shareef, Qasim Muhammad, Jahan Shah, Shamsi Farwa Batool, Yousaf Muhammad, TGF-β1 rs1800469 gene polymorphism in the development of cirrhosis & hepatocellular carcinoma in Pakistani HCV patients, Future Virology, 14, 10, 2019. Crossref

  7. Iqbal Muhammad Sarfaraz, Ashfaq Usman Ali, Khaliq Saba, Masoud Muhammad Shareef, Qasim Muhammad, Haque Asma, Ghani Muhammad Usman, Jahan Shah, Toll-like receptor 4 polymorphism as pretreatment predictor of response to HCV genotype 3a interferon-based treatment, Future Virology, 12, 12, 2017. Crossref

  8. Sokolova T. M., Hepatitis C virus (Flaviviridae: Hepacivirus: Hepacivirus C): regulation of signaling reactions of innate immunity, Problems of Virology, 65, 6, 2021. Crossref

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