RESUMO

Effects of taurine and endogenous nitric oxide on gastric secretion and taurineinduced changes in the secretory process following blockade of nitric oxide synthesis were studied in chronic experiments on dogs with gastric fistulas. The intensity of gastric secretion was determined during 1.5 hours, as well as the content of hydrochloric acid, pepsin, total proteins and adenine system components. Inhibition of NO-synthase by L-NAME evokes an increase in the volume of histamine stimulated gastric secretion by 160% (P < 0.001), hydrochloric acid content by 156.4% (P < 0.001), pepsin content - by 184.1% (P < 0.001), as compared with control. Taurine increases the volume of histamine stimulated gastric secretion by 129.3% (P < 0.001), hydrochloric acid - by 151.4% (P < 0.001), pepsin - by 172.2% (P < 0.001), total proteins - by 60.5% (P < 0.001) as compared with control. Blockade of nitric oxide synthesis does not alter the effect of taurine on histamine stimulated gastric secretion. The obtained results suggest that endogenous nitric oxide inhibits gastric secretion, and it is not involved in the regulatory effects of taurine on gastric secretory function.